Viral etiology of suspected ebola virus disease cases in West Africa

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine; Virology
• Research Institution: Nagasaki University
• Principal Investigator: KUROSAKI Yohei 長崎大学, 熱帯医学研究所, 助教 (40415443)
• Research Collaborator: Magassouba N' Faly ギニア国家出血熱対策プロジェクト, ウイルス診断部長
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: エボラウイルス病 / 西アフリカ / 感染疫学 / ウイルス / シークエンス

Outline of Final Research Achievements

The aim of this study was to determine the etiology of non-Ebola virus disease (EVD) cases, which showed EVD-like clinical signs, but were excluded viral infection by a laboratory testing, in the recent endemic of the disease in West Africa. In the collaboration with the National Donka Hospital in Guinea, we conducted screening detection of viruses which causes systematic febrile illness and malaria on the 71 samples from non-EVD cases. We detected dengue virus, enteroviruses, measles virus, and malaria positive cases in these samples, and determined the genotype of the detected viruses using partial or whole genome sequences by Sanger or next generation sequencing. These results suggested that these viruses and malaria caused clinical symptoms similar to EVD, and should be differentiated from EVD in clinical and laboratory diagnosis. Furthermore, these results suggested that these viral diseases have been endemic in Guinea.

Free Research Field

ウイルス学