2017 Fiscal Year Final Research Report
Production and nutritional aspects of fat containing skeletal muscles using food materials to improve insulin resistance
| Project/Area Number |
16K21349
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
Eating habits
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
NOZAKI Tsutomu
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | インスリン抵抗性 / PPARγ / 黒ショウガ / 骨格筋 / 脂質 / ２型糖尿病 |
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| Outline of Final Research Achievements |
Muscular fat accumulation can lead to the onset of type-2 diabetes mellitus, but fat content is highly accumulated in muscles of endurance athlete. This is well called “athlete paradox”. As a PPARγ agonist to stimulate adiponectin production and its secretion, ethanol extract of Kaempferia parviflora was selected. From the animal studies using a PPARγ agonist and its antagonist, ethanol extract of Kaempferia parviflora showed PPAR agonistic activities and improved glucose tolerance without excess fat accumulation in skeletal muscles. These results can indicate that the anti-type-2 diabetes mellitus effects were caused by not only the activation of PPARγ but also other mechanisms. And, as food factors to produce fat containing muscles, 5, 7-dimethoxyflavones were also one of effective.
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| Free Research Field |
食品科学
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