The effects of AMP-activated protein kinase on inactivity-induced insulin resistance

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21572
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Sports science
• Research Institution: Nagaoka National College of Technology
• Principal Investigator: KAWAMOTO EMI 長岡工業高等専門学校, 物質工学科, 准教授 (40634514)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: AMPキナーゼ / 不活動 / インスリン抵抗性 / ルチン

Outline of Final Research Achievements

Physical inactivity induces insulin resistance in skeletal muscle. In this study, we examined whether activation of AMP-activated protein kinase (AMPK) decreased in rat soleus muscle by using unilateral hindlimb immobilization model. As a result, no decrease in the phosphorylation level of AMP kinase, which indicates activation of AMP kinase, was observed in immobilized muscle. Also, in order to prevent inactivity-induced development of muscle insulin resistance, rutin which is a kind of plant-derived polyphenol was administered, but its preventive effect was not obtained.

Free Research Field

健康・スポーツ科学