2009 Fiscal Year Final Research Report
Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
| Project/Area Number |
17013024
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Toyama (2006-2009)
The University of Tokyo (2005) |
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Principal Investigator |
TAKATSU Kiyoshi University of Toyama, 大学院・医学薬学研究部, 教授 (10107055)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Yoshinori 富山大学, 医学薬学研究部, 准教授 (30431761)
KARIYONE Ai 富山大学, 医学薬学研究部, 助教 (50114450)
IKUTANI Masashi 富山大学, 医学薬学研究部, 助教 (40513718)
TAMURA Toshiki ハンセン病研究センター, 室長 (40291306)
HONDA Hiroe 富山県薬事研究所, 主任研究員 (10463134)
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| Project Period (FY) |
2005 – 2009
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| Keywords | Ag85B / Peptide-25 / Th1 / Th2 / 抗原提示細胞 / クロスプレゼンテーション / 抗腫瘍免疫増強 / IFN-γ / アジュバント活性 |
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| Research Abstract |
(1) Using P25 TCR-Tg mice, we demonstrated that direct interaction between TCR and peptide-loaded antigen-presenting cells primarily determines the fate of naive CD4^+ T cells, even in the absence of T-bet expression and costimulatory signals. (2) Coimmunization of mice with P25 and OVA resulted in the enhancement of CD8^+ cytotoxic T cells specific for OVA and growth inhibition of EL-4 thymoma expressing OVA peptide leading to the tumour rejection, indicating that P25 exerts a potent adjuvant activity for antitumour immunity. (3) P25-stimulated P25 CD4^+ T cells augment antigen cross-presentation by APC. IFN-γ and IFN-γ-inducible genes play indispensable roles the Th1-mediated cross-presentation.
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[Journal Article] Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo2010
Author(s)
Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okumura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K
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Journal Title
The Journal of Clinical Investigation 120
Pages: 179-190
Peer Reviewed
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[Journal Article] Suppressed induction of mycobacterial antigen-specific Th1-type CD4 + T cells in the lung after pulmonary mycobacterial infection2010
Author(s)
Yahagi A, Umemura M, Tamura T, Kariyone A, Begum MD, Kawakami K, Okamoto Y, Hamada S, Oshiro K, Kohama H, Arakawa T, Ohara N, Takatsu K, Matsuzaki G
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Journal Title
International Immunology 22
Pages: 307-308
Peer Reviewed
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