2009 Fiscal Year Final Research Report
Anti-viral immuno therapeutic approaches for adult T-cell leukemia
| Project/Area Number |
17013028
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KANNAGI Mari Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80202034)
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| Co-Investigator(Kenkyū-buntansha) |
HARASHIMA Nanae 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 (60345311)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ウイルス / 癌 / トラスレーショナルリサーチ / 免疫学 / HTLV-I / ATL / ワクチン |
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| Research Abstract |
Our previous studies suggested that immunological approaches to activate HTLV-I-specific T-cell response potentially induce prophylactic and therapeutic effects on ATL. In order to verify this notion and apply for bedside, we indicated that vaccination reduced proviral load in a rat model, and that a subpopulation of HTLV-I-carriers showed weak HTLV-I-specific T-cell response and elevated proviral load. Moreover, we discovered an innate immune-mediated mechanism suppressing HTLV-I expression in vivo.
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[Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.2009
Author(s)
Y. Shimizu, A. Takamori, A. Utsunomiya, M. Kurimura, Y. Yamano, M. Hishizawa, A. Hasegawa, F. Kondo, K. Kurihara, N. Harashima, T. Watanabe, J. Okamura, T. Masuda, M. Kannagi
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Journal Title
Cancer Sci. 100
Pages: 481-489
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[Journal Article] Allogeneic Hematopoietic stem cell transplantation using reduced-intensity conditioning for adult T cell leukemia/lymphoma: Impact of antithymocyte glogulin on clinical outocome.2008
Author(s)
R. Tanosaki, N. Uike, A. Utsunomiya, Y. Saburi, M. Masuda, M. Tomonaga, T. Eto, M. Hidaka, M. Harada, I. Choi, T. Yamanaka, M. Kannagi, M. Matsuoka, J. Okamura
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Journal Title
Biology of Blood and Marrow Transplantation 14
Pages: 702-708
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[Journal Article] for ATL-RIST study group. Allogeneic stem cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma.2005
Author(s)
J. Okamura, A. Utsunomiya, R. Tanosaki, N. Uike, S. Sonoda, M. Kannagi, M. Tomonaga, M. Harada, N. Kimura, M. Masuda, F. Kawano, Y. Yufu, H. Hattori, H. Kikuchi, Y. Saburi
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Journal Title
Blood. 105
Pages: 4143-4145
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[Journal Article] Potential immunogenicity of Adult T cell Leukemia cells in vivo.2005
Author(s)
K. Kurihara, N. Harashima, S. Hanabuchi, M. Masuda, A. Utsunomiya, R. Tanosaki, M. Tomonaga, T. Ohashi, A. Hasegawa, T. Masuda, J. Okamura, Y. Tanaka, M. Kannagi
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Journal Title
Int. J. Cancer 114
Pages: 257-267
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