2009 Fiscal Year Final Research Report
Genetic approach to elucidate roles of stomach cancer related genes
| Project/Area Number |
17013066
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMAMOTO Ken Kyushu University, 生体防御医学研究所, 准教授 (60274528)
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| Project Period (FY) |
2005 – 2009
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| Keywords | がん / ゲノム / 遺伝子多型 / 相関解析 / 連鎖解析 / 細胞死 / リジンメチル化 |
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| Research Abstract |
Genome-wide linkage study followed by association analyses on candidate chromosomes revealed stomach cancer-related gene, STCH, on chromosome 21. We indicated that STCH localizes ER and is involved in apoptosis pathway. Somatic mutation was identified in STCH gene in stomach cancer. We demonstrated that the STCH mutation endows anti-apoptotic property to cells. We also identified novel chromosomal aberrations of stomach cancer which will be important targets in future research for better understanding of stomach cancer pathogenesis.
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[Journal Article] P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance2010
Author(s)
Shiota M, Yokomizo A, Tada Y, Uchiumi T, Inokuchi J, Tatsugami K, Kuroiwa K, Yamamoto K, Seki N, Naito S
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Journal Title
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[Journal Article] Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence2007
Author(s)
Shide K, Shimoda K, Kamezaki K, Kakumitsu H, Kumano T, Numata A, Ishikawa F, Takenaka K, Yamamoto K, Matsuda T, Harada M
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Journal Title
Leuk Res. 31(8)
Pages: 1077-1084
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[Journal Article] A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population2005
Author(s)
Aoki M, Yamamoto K, Ohyama S, Yamamura Y, Takenoshita S, Sugano K, Minamoto T, Kitajima M, Sugimura H, Shimada S, Noshiro H, Hiratsuka M, Sairenji M, Ninomiya I, Yano M, Uesaka K, Matsuno S, Maehara Y, Aikou T, Sasazuki T
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Journal Title
Biochem Biophys Res Commun 335(2)
Pages: 566-574
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[Journal Article] A full genome scan for gastric cancer2005
Author(s)
Aoki M, Yamamura Y, Noshiro H, Sakai K, Yokota J, Kohno T, Tokino T, Ishida S, Ohyama S, Ninomiya I, Uesaka K, Kitajima M, Shimada S, Matsuno S, Yano M, Hiratsuka M, Sugimura H, Itoh F, Minamoto T, Maehara Y, Takenoshita S, Aikou T, Katai H, Yoshimura K, Takahashi T, Akagi K, Sairenji M, Yamamoto K, Sasazuki T
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Journal Title
J Med Genet 42(1)
Pages: 83-87
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