p53 family : function and cancer therapy

2009 Fiscal Year Final Research Report

• Project/Area Number: 17013072
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Sapporo Medical University
• Principal Investigator: TOKINO Takashi Sapporo Medical University, 医学部, 教授 (40202197)
• Project Period (FY): 2005 – 2009
• Keywords: 癌 / 癌抑制遺伝子 / 遺伝子治療 / p53 / p63 / p73 / アポトーシス

Research Abstract

Our in silico approach is powerful for identification of p53 target genes and for further understanding the function of p53 in tumorigenesis. We identified that PEDF, FLOT2, and APOD are direct transcriptional targets of the p53 family member genes. We found that significant antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines in a mouse model. Furthermore, the histone deacetylase inhibitor FK228 was found to enhance adenovirus-mediated p53 family gene therapy in cancer models.

Research Products

• [Journal Article] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (2010)
  • Author(s): Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa J-P J, Shinomura Y, Tokino T, Toyota M
  • Journal Title: Carcinogenesis 31(3) Pages: 342-349
  • Peer Reviewed
• [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. (2009)
  • Author(s): Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
  • Journal Title: Clinical Cancer Research 15(11) Pages: 3725-3732
  • Peer Reviewed
• [Journal Article] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2009)
  • Author(s): Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T
  • Journal Title: Oncogene 28(29) Pages: 2643-2653
  • Peer Reviewed
• [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene. (2009)
  • Author(s): Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
  • Journal Title: J Biol Chem 284(2) Pages: 872-883
  • Peer Reviewed
• [Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. (2009)
  • Author(s): Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
  • Journal Title: BMC Cancer 9 Pages: 198
  • Peer Reviewed
• [Journal Article] A novel biomarker for cervical cancer. (2009)
  • Author(s): Tokino T
  • Journal Title: Cancer Biology Therapy 8(12) Pages: 1154-1155
  • Peer Reviewed
• [Journal Article] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multiple myeloma. (2009)
  • Author(s): Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
  • Journal Title: Clinical Cancer Research 15(13) Pages: 4356-4364
  • Peer Reviewed
• [Journal Article] Cancer epigenomics: Implications of DNA methylation in personalized cancer therapy. (2009)
  • Author(s): Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y
  • Journal Title: Cancer Science 100(5) Pages: 787-791
  • Peer Reviewed
• [Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity. (2009)
  • Author(s): Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
  • Journal Title: Int J Cancer 124(11) Pages: 2607-2615
  • Peer Reviewed
• [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirusmediated p53 family gene therapy in cancer models. (2008)
  • Author(s): Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
  • Journal Title: M o l e c u l a r C a n c e r T h e r a p e u t i c s 7(4) Pages: 779-787
  • Peer Reviewed
• [Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members. (2008)
  • Author(s): Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
  • Journal Title: M o l e c u l a r C a n c e r R e s 6(3) Pages: 395-406
  • Peer Reviewed
• [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer. (2008)
  • Author(s): Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
  • Journal Title: G a s t r o e n t e r o l o g y 135(1) Pages: 142-151
  • Peer Reviewed
• [Journal Article] A requirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. (2008)
  • Author(s): Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
  • Journal Title: C a n c e r R e s e a r h 68(8) Pages: 2570-2575
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer. (2008)
  • Author(s): Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a n c e r R e s e a r c h 68(11) Pages: 4124-4132
  • Peer Reviewed
• [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer. (2008)
  • Author(s): Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a r c i n o g e n e s i s 29(7): 29(7) Pages: 1312-1318
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. (2008)
  • Author(s): Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
  • Journal Title: B r J C a n c e r 98(6) Pages: 1147-1156
  • Peer Reviewed
• [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors. (2008)
  • Author(s): Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
  • Journal Title: P h a r m a c o g e n o m i c s 9(12) Pages: 1917-1928
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma. (2008)
  • Author(s): Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
  • Journal Title: C a n c e r S c i e n c e 99(5) Pages: 958-966
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma. (2008)
  • Author(s): Sogabe Y, Suzuki H, Toyata M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T
  • Journal Title: I n t J O n c o l o g y 32(6) Pages: 1253-1261
  • Peer Reviewed
• [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis. (2008)
  • Author(s): Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Muruyama R, Nojima M, Ashisa M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
  • Journal Title: C a n c e r E p i d e m i o l B i o m a r k e r s P r e v 17(10) Pages: 2555-2564
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma. (2008)
  • Author(s): Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
  • Journal Title: J G a s t r o e n t e r o l 43(5) Pages: 378-389
  • Peer Reviewed
• [Journal Article] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells. (2008)
  • Author(s): Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
  • Journal Title: J H e p a t o b i l i a r y P a n c r e a t S u r g 15(3) Pages: 310-317
  • Peer Reviewed
• [Journal Article] Gene Amplification and Overexpression of PRDM14 in Breast Cancers. (2007)
  • Author(s): Nishikawa N, Toyota M, Suzuki H, Honma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
  • Journal Title: C a n c e r R e s e a r c h 67(20) Pages: 9649-9657
  • Peer Reviewed
• [Journal Article] Antitumor effect of adenovirusmediated p53 family gene transfer on osteosarcoma cell lines. (2007)
  • Author(s): Oshima Y, Sasaki Y, Negishi H, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T
  • Journal Title: C a n c e r B i o l o g y T h e r a p y 6(7) Pages: 1058-1066
  • Peer Reviewed
• [Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer. (2007)
  • Author(s): Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Tokino T
  • Journal Title: C l i n i c a l C a n c e r R e s 13(16) Pages: 4786-4794
  • Peer Reviewed
• [Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate betacatenine and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling. (2007)
  • Author(s): Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura, Imai K, Hirohashi S, Yamada T
  • Journal Title: C a n c e r R e s e a r c h 67(3) Pages: 911-918
  • Peer Reviewed
• [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. (2007)
  • Author(s): Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a n c e r S c i e n c e 98(1) Pages: 88-95
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. (2007)
  • Author(s): Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
  • Journal Title: O n c o g e n e 26(32) Pages: 4699-4713
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. (2007)
  • Author(s): Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
  • Journal Title: C a r c i n o - g e n e s i s 28(12) Pages: 2459-2466
  • Peer Reviewed
• [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006)
  • Author(s): Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a n c e r R e s e a r c h 66(9) Pages: 4574-83
  • Peer Reviewed
• [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus. (2006)
  • Author(s): Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
  • Journal Title: C a n c e r 106(7) Pages: 1467-1479
  • Peer Reviewed
• [Journal Article] Implications for gene therapy treatment of human glioblastomas. (2006)
  • Author(s): Kang X, Xiao X, Harata M, Bai Y, Nakazaki Y, Soda Y, Kurita R, Tanaka T, Komine F, Izawa K, Kunisaki R, Setoyama M, Nishimori H, Natsume A, Sunamura M, Lozonshi L, Saitoh I, Tokino T, Asano S, Nakamura Y, Tani K: Antiangiogenic potency of BAI1 in vivo
  • Journal Title: C a n c e r G e n e T h e r a p y 13(4) Pages: 385-392
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinama. (2006)
  • Author(s): Okuda H, Toyota M, Ishida W, Furihata M, Tsuchiya M, Kamada M, Tokino T, Shuinn T
  • Journal Title: O n c o g e n e 25(12) Pages: 1733-1742
  • Peer Reviewed
• [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis (2006)
  • Author(s): King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC, Weinberg WC
  • Journal Title: C a r c i n o g e n e s i s 27(1) Pages: 53-63
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. (2006)
  • Author(s): Terasawa K, Toyota M, Sagae S, Ogi K, Suzuki H, Sonoda T, Akino K, Maruyama R, Nishikawa N, Imai K, Shinohara Y, Saito T, Tokino T
  • Journal Title: B r J C a n c e r 94(6) Pages: 914-921
  • Peer Reviewed
• [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. (2006)
  • Author(s): Kobayashi T, Sasaki Y, Oshima Y, Yamamoto H, Mita H, Suzuki H, Toyota Y, Tokino T, Itoh F, Imai K, Shinomura Y
  • Journal Title: I n t J M o l M e d 18(1) Pages: 161-170
  • Peer Reviewed
• [Journal Article] Identification of pigment epithelium derived factor as a direct target of the p53 family member genes. (2005)
  • Author(s): Sasaki Y, Naishiro Y, Oshima Y, Imai K, Nakamura Y, Tokino T
  • Journal Title: O n c o g e n e 24(32) Pages: 5131-5136
  • Peer Reviewed
• [Journal Article] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer. (2005)
  • Author(s): Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa J-P J, Hinoda Y, Imai K, Tokino T
  • Journal Title: G a s t r o e n t e r o l o g y 129(1) Pages: 156-169
  • Peer Reviewed
• [Journal Article] Identification of laminin b3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. (2005)
  • Author(s): Irifune H, Nishimori H, Watanabe G, Yoshida K, Ikeda T, Matsui C, Morohashi M, Kawaguchi S, Nagoya S, Wada T, Yamashita T, Nakamura Y, Tokino T
  • Journal Title: C a n c e r B i o l o g y T h e r a p y 4(4) Pages: 449-455
  • Peer Reviewed
• [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtuble inhibitors. (2005)
  • Author(s): Ogi K, Toyota M, Mita H, Satoh A, Kashima L, Sasaki Y, Suzuki H, Akino K, Nishikawa N, Shinomura Y, Imai K, Hiratsuka H, Tokino T
  • Journal Title: C a n c e r B i o l o g y T h e r a p y 4(7) Pages: 773-780
  • Peer Reviewed
• [Journal Article] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation. (2005)
  • Author(s): Simbulan-Rosethal CM, Trabosh V, Velarde A, Chou FP, Daher A, Tenzin F, Tokino T, Rosenthal DS
  • Journal Title: O n c o g e n e 24(35) Pages: 5443-5458
  • Peer Reviewed
• [Journal Article] Upregulation of BNIP3 by 5-aza-2 ' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. (2005)
  • Author(s): Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K
  • Journal Title: J G a s t r o e n t e r o l 40(5) Pages: 504-510
  • Peer Reviewed
• [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours. (2005)
  • Author(s): Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, Issa JP, Hinoda Y, Tokino T, Imai K
  • Journal Title: B r J C a n c e r 92(6) Pages: 1165-1172
  • Peer Reviewed
• [Journal Article] Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. (2005)
  • Author(s): Odajima T, Sasaki Y, Tanaka N, Kato-Mori Y, Asanuma H, Ikeda T, Satoh M, Hiratsuka H, Tokino T, Sawada N
  • Journal Title: H u m P a t h o l 36(3) Pages: 234-241
  • Peer Reviewed
• [Journal Article] The role of T-fimbrin in the response to DNA damage: Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents. (2005)
  • Author(s): Ikeda H, Sasaki Y, Kobayashi T, Suzuki H, Mita H, Toyota M, Itoh F, Shinomura Y, Tokino T, Imai K
  • Journal Title: I n t J O n c o l 27(4) Pages: 933-40
  • Peer Reviewed
• [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. (2005)
  • Author(s): Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K
  • Journal Title: C l i n i c a l C a n c e r R e s 11(3) Pages: 1021-1027
  • Peer Reviewed
• [Journal Article] Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy. (2005)
  • Author(s): Takemura K, Noguchi M, Ogi K, Tokino T, Kubota H, Miyazaki A, Kohama G, Horatsuka H
  • Journal Title: J O r a l P a t h o l M e d 34(2) Pages: 93-99
  • Peer Reviewed
• [Journal Article] Tight junction proteinMAGi-1 is up-regulated by tranfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. (2005)
  • Author(s): Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N
  • Journal Title: C e l l T i s s u e R e s 319(2) Pages: 341-347
  • Peer Reviewed
• [Journal Article] A full genome scan for gastric cancer. (2005)
  • Author(s): AokiM,YamamuraY,NoshiroH,SakaiK,YokotaJ,KohnoT,TokinoT,IshidaS,OhyamaS,NinomiyaI,UesakaK,KitajimaM,ShimadaS,MatsunoS,YanoM,HiratsukaM,SugimuraH,ItohF,MinamotoT,MaeharaY,TakenoshitaS,AikouT,KataiH,Yoshimura K, TakahashiT,AkagiK,SairenjiM,YamamotoK,SasazukiT
  • Journal Title: J M e d i c a l G e n e t i c s 42(1) Pages: 83-87
  • Peer Reviewed
• [Journal Article] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
  • Author(s): Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T
  • Journal Title: Breast Cancer Res Treat (in press)
  • Peer Reviewed
• [Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2010)
  • Author(s): Tokino T, Kashima L, Toyota M, Sasaki Y.
  • Organizer: 101th American Association of Cancer Research (AACR) Annual Meeting
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2010-04-20
• [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer. (2010)
  • Author(s): Tokino T, Idogawa M, Sasaki Y.
  • Organizer: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association.
  • Place of Presentation: Hawaii, USA.
  • Year and Date: 2010-02-09
• [Presentation] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members. (2008)
  • Author(s): Tokino T, Sasaki Y.
  • Organizer: 99th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2008-04-14
• [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. (2007)
  • Author(s): Tokino T, Oshima Y, Yamashita T, Sasaki Y.
  • Organizer: 98th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: Los Angeles, USA.
  • Year and Date: 2007-04-17
• [Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes. (2006)
  • Author(s): Tokino T, Sasaki Y.
  • Organizer: 97th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2006-04-03
• [Presentation] Identification of laminin beta 3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumor. (2005)
  • Author(s): Tokino T, Irifune H, Sasaki Y, Yoshida K, Kawaguchi S, Wada T, Yamashita T.
  • Organizer: 96th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: Anaheim, USA.
  • Year and Date: 2005-04-19
• [Remarks]
  • URL: http://web.sapmed.ac.jp/canmol/