2009 Fiscal Year Final Research Report
Molecular mechanism of tumor cell growth
| Project/Area Number |
17014011
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKIYAMA Tetsu The University of Tokyo, 分子細胞生物学研究所, 教授 (70150745)
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| Co-Investigator(Kenkyū-buntansha) |
NASU Ryo 東京大学, 分子細胞生物学研究所, 助教 (30466859)
KAWASAKI Yoshihiro 東京大学, 分子細胞生物学研究所, 助教 (10376642)
NAKAMURA Tsutomu 東京大学, 分子細胞生物学研究所, 助教 (30302798)
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| Project Period (FY) |
2005 – 2009
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| Keywords | がん抑制遺伝子 / がん遺伝子 / アポトーシス / 増殖 / p53 / APC / Asef |
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| Research Abstract |
We identified D8 as a p53 target gene and found that D8 is involved in genome stress-induced apoptotic cell death. We also identified Asef and Asef2, guanine nucleotide exchange factors that are activated by the tumor suppressor APC, and found that they are critically involved in intestinal adenoma formation and tumor progression and may be promising molecular targets for therapy of colorectal tumors.
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Research Products
(20 results)
