2009 Fiscal Year Final Research Report
Analysis of blood vessel formation in the tumor environment
| Project/Area Number |
17014033
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University (2006-2009)
Kanazawa University (2005) |
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Principal Investigator |
TAKAKURA Nobuyuki Osaka University, 微生物病研究所, 教授 (80291954)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Masaya 大阪大学, 微生物病研究所, 助教 (20334766)
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| Co-Investigator(Renkei-kenkyūsha) |
UENO Masaya 大阪大学, 微生物病研究所, 助教 (20334766)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / 発生・分化 |
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| Research Abstract |
As newly developed blood vessels in tumor environment supply oxygen and nutrient to cancer cells resulted in growth of tumor, we analyzed the molecular mechanisms of blood vessel formation in cancer to develop a good strategy for inhibition of tumor angiogenesis. We found that cancer stem cells locate near the mature blood vessels in the tumor edge that show resistance against angiogenesis inhibitors. Moreover, we found that maturation of blood vessels in tumor is caused by the transdifferentiation of hematopoietic stem cells into mural cells which support stability of blood vessels and associates with activation of receptors, Tie2 and APJ expressed on endothelial cells.
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