2009 Fiscal Year Final Research Report
Molecular mechanisms of cell-cell adhesion in cancer cells
| Project/Area Number |
17014044
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kobe University (2006-2009)
Kyoto University (2005) |
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Principal Investigator |
FURUSE Mikio Kobe University, 大学院・医学学研究科, 教授 (90281089)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKITA Sachiko 大阪大学, 大学院・生命機能研究科, 教授 (00188517)
ADACHI Makoto 京都大学, 大学院・医学研究科, 助手 (30335244)
KUBO Akiharu 京都大学, 大学院・医学研究科, 助手 (70335256)
TAMURA Atsushi 大阪大学, 大学院・生命機能研究科, 特任助教 (00362525)
ODA Yukako 神戸大学, 大学院・医学研究科, 助教 (70452498)
SASAKI Hiroyuki 東京慈恵会医科大学, 医学部, 准教授 (60170693)
中尾 和貴 独立行政法人理化学研究所, 研究員 (20217657)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 上皮細胞 / 細胞接着 / タイトジャンクション / クローディン |
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| Research Abstract |
The tight junction is one of the characteristic structures in epithelial cells, from which cancer is derived, and works as a barrier to restrict the free diffusion of solutes through the intercellular space. In this study, we investigated the molecular structure and function of tight junctions. We found that the artificial modification of the barrier property of tight junctions accelerates growth of intestinal epithelial cells and results in enlargement of the intestine. We also clarified for the first time the molecular constituents of tricellular contacts.
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[Journal Article] Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules.2010
Author(s)
Muto S, Hata M, Taniguchi J, Tsuruoka S, Moriwaki K, Saitou M, Furuse K, Sasaki H, Fujimura A, Imai M, Kusano E, Tsukita S, Furuse M.
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Journal Title
Proc Natl Acad Sci U S A 107
Pages: 8011-8016
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[Journal Article] Megaintestine in claudin-15-deficient mice2008
Author(s)
Tamura A, Kitano Y, Hata M, Katsuno T, Moriwaki K, Sasaki H, Hayashi H, Suzuki Y, Noda T, Furuse M, Tsukita S, Tsukita S.
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Journal Title
Gastroenterology 134
Pages: 523-534
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[Journal Article] Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice.2005
Author(s)
Miyamoto T, Morita K, Takemoto D, Takeuchi K, Kitano Y, Miyakawa T, Nakayama K, Okamura Y, Sasaki H, Miyachi Y, Furuse M, Tsukita S.
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Journal Title
J Cell Biol 169
Pages: 527-538
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[Presentation] Overlapping and distinct functions of two jomologous, PDZ domain-containing tight junction proteins, MUPP-1 and Patj.2006
Author(s)
Adachi, M, Hamazaki Y, Kobayashi Y, Itoh M, Sasaki H, Takai Y, Furuse M, Tsukita S.
Organizer
20th IUBMB International Congress of Biochemistry and Molecular Biology.
Place of Presentation
京都
Year and Date
20060618-20060623
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