2009 Fiscal Year Final Research Report
Cancer epidemiological studies for Japanese immigrants and development of preventive strategy for cancer based on the evidence from the studies
| Project/Area Number |
17015049
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
TSUGANE Shoichiro National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 予防研究部, 部長 (40179982)
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Motoki 国立がんセンター(研究所及び東病院臨床開発センター), 予防研究部, 室長 (60392338)
OTANI Tetsuya 国立がんセンター(研究所及び東病院臨床開発センター), 予防研究部, 研究員 (70392339)
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| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Gerson Shigueaki Nikkei Disease Prevention Center, Director
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| Project Period (FY) |
2005 – 2009
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| Keywords | ブラジル日系移民 / がん / 乳がん / 大腸腺腫 / 症例対照研究 / 断面研究 / 環境要因 / 遺伝的素因 |
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| Research Abstract |
We have conducted epidemiological studies such as cross-sectional and case-control study among Japanese Brazilians living in Sao Paulo. In case-control studies for breast cancer, we analyzed data from in three populations : Japanese living in Japan, Japanese Brazilians living in Sao Paulo, and non-Japanese Brazilians living in Sao Paulo. We found an inverse association between isoflavone intake and breast cancer risk, and stratified analysis suggested that polymorphisms in the estrogen receptor beta, 17β-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk. We found no overall association between folate, vitamin B6, and vitamin B12 intake and the risk of breast cancer. In a cross-sectional study of colorectal adenoma among Japanese Brazilians living in Sao Paulo, Brazil, participants have been recruited in two hospitals and we completed a survey from 719 participates at the end of March, 2010.
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Research Products
(16 results)
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[Journal Article] Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17 β-HSD1 and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.2010
Author(s)
Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S.
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Journal Title
Nutr Cancer 62
Pages: 466-75
Peer Reviewed
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[Journal Article] Dietary isoflavone intake and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.2009
Author(s)
Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S.
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Journal Title
Breast Cancer Res Treat. 116
Pages: 401-11
Peer Reviewed
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[Journal Article] Genetic polymorphisms in estrogen metabolism and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians.2009
Author(s)
Shimada N, Iwasaki M, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Hamada GS, Nishimoto IN, Iyeyasu H, Motola J Jr, Laginha FM, Kurahashi N, Tsugane S.
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Journal Title
J Hum Genet. 54
Pages: 209-15
Peer Reviewed
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[Journal Article] Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.2009
Author(s)
Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S.
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Journal Title
Cancer Sci. 100
Pages: 927-33
Peer Reviewed
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[Journal Article] Development of a Quantitative Food Frequency Questionnaire for assessing food, nutrient, and heterocyclic aromatic amine intake in Japanese Brazilians for a colorectal adenoma case-control study.2009
Author(s)
Sharma S, Iwasaki M, Kunieda C, Cao X, Ishihara J, Hamada G, Miyajima NT, Tsugane S, Le March, L.
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Journal Title
Int J Food Sci Nutr 20
Pages: 1-12
Peer Reviewed
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[Journal Article] Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.2009
Author(s)
Ma E, Iwasaki M, Ishihara J, Hamada GS, Nishimoto IN, Carvalho SM, Motola J Jr, Laginha FM, Tsugane S.
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Journal Title
Peer Reviewed
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[Presentation] Dietary isoflavone intake, polymorphisms in estrogen receptor genes and the risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.2008
Author(s)
Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S.
Organizer
VIII IEA World Congress of Epidemiology
Place of Presentation
Porto Alegre
Year and Date
20080920-20080924
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[Presentation] Dietary isoflavone intake, polymorphisms in CYP17, CYP19, 17 β-HSD1 and SHBG genes, and the risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.2008
Author(s)
Tsugane S, Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T.
Organizer
XVIII IEA World Congress of Epidemiology
Place of Presentation
Porto Alegre
Year and Date
20080920-20080924
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