4次元定位放射線治療の基礎

2007 Fiscal Year Annual Research Report

• Project/Area Number: 17016002
• Research Institution: Hokkaido University
• Principal Investigator: 白土 博樹 Hokkaido University, 大学院・医学研究院, 教授 (20187537)
• Co-Investigator(Kenkyū-buntansha): 高田 英治 富山工業高等専門学校, 准教授 (00270885) ; 金子 純一 北海道大学, 大学院・工学研究科, 准教授 (90333624) ; 西山 修輔 北海道大学, 大学院・工学研究科, 准教授 (30333628) ; 青山 英史 北海道大学, 北海道大学病院, 講師 (80360915) ; 関 與一 北海道大学, アイソトープ総合センター, 教授 (60094835)
• Keywords: 放射線治療 / 核医学診断技術 / 動体追跡放射線治療 / スポットスキャン / 低酸素細胞 / 画像誘導放射線治療

Research Abstract

体内の微小な癌組織が抗原抗体反応などで取り込むアイソトープを利用し、ポジトロンエミッターからのガンマ線を体外から検出することで、動体追跡放射線治療を金マーカーなしで行う方法を検討してきた。これまで行ってきた簡易計算プログラムによる概念設計の結果、18F-FDGを利用した場合、SUV=5であれば直径5cmの腫瘍(放射能:18.5kBq/cc)の変動を5mm以下の精度で検出可能という結果を得た。TOF(Time of Flight)に関するシミュレーションを行い、効果を評価した。4次元分割に関する研究を進め、膵がんでの4次元強度変調放射線治療の臨床研究を開始した。
電子線を任意の部位に加速する技術は深部臓器でのピンポイント照射精度の上で限界があることが示された。レーザー加速による陽子線治療を離床したスポットスキャン法での眼腫瘍の治療に関するモンテカルロシミュレーションを行い、適切な線量分布を得ることが可能であることが判明した。
低酸素細胞に特異的に取り込まれる放射線医薬品を、4次元定位放射線治療における癌組織の部位を示すマーカーとして利用可能かどうかを調べるために、18F-MISOの利用に関する前臨床試験を行い十分可能であることが示された。半導体PETや高精度MRIでの低酸素細胞の把握が治療計画に利用可能であることが示唆された。

Research Products

• [Journal Article] Histopathologic consideration of fiducial gold markers inserted for real-time tumor-tracking radiotherapy against lung cancer (2008)
  • Author(s): Imura, M., Yamazaki, K., Kubota, KC., Itoh, T., Onimaru, R., Cho, Y., Hida, Y., Kaga, K., Onodera, Y., Ogura, S., Dosaka-Akita, H., Shirato, H., Nishimura, M
  • Journal Title: Int J Radiat Oncol Biol Phys 1;70(2) Pages: 382-384
  • Peer Reviewed
• [Journal Article] Three-dimensional intrafractional motion of breast during tangential breast irradiation monitored with high-sampling frequency using a real-time tumor-tracking radiotherapy system (2008)
  • Author(s): Kinoshita, R., Shimizu, S., Taguchi, H., Katoh, N., Fujino, M., Onimaru, R., Aoyama, H., Katoh, F., Omatsu, T., Ishikawa, W., Shirato, H
  • Journal Title: Int J Radiat Oncol Biol Phys 28(1) Pages: 155-159
  • Peer Reviewed
• [Journal Article] Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy. (2008)
  • Author(s): Onimaru, R., Fujino, M., Yamazaki, K., Onodera, Y., Taguchi, H., Katoh, N., Hommura, F., Oizumi, S., Nishimura, M., Shirato, H.
  • Journal Title: International Journal of Radiation Oncology Biology Physics 70(2) Pages: 374-381
  • Peer Reviewed
• [Journal Article] Exhale fluctuation in respiratory-gated radiotherapy of the lung:A pitfall of respiratory gating shown in a synchronized internal/external marker recording study. (2008)
  • Author(s): Nishioka, S., Nishioka, T., Kawahara, M., Tanaka, S., Hiromura, T., Tomita, K., Shirato, H
  • Journal Title: Radiotherapy and Oncology 86(1) Pages: 69-76
  • Peer Reviewed
• [Journal Article] Usefulness of 11C-methionine for differentiating tumors from granulomas in experimental rat models: a comparison with 18F-FDG and 18F-FLT. (2008)
  • Author(s): Zhao, S, et. al.
  • Journal Title: J Nucl Med 49(1) Pages: 135-141
  • Peer Reviewed
• [Journal Article] Transcatheter arterial embolization with absolute ethanol injection for enlarged polycystic kidneys after failed metallic coil embolization. (2008)
  • Author(s): Sakuhara, Y, et. al.
  • Journal Title: J Vasc Interv Radiol 19 Pages: 267-271
  • Peer Reviewed
• [Journal Article] Evaluation of the vascular supply to regions of the pancreas on CT during arteriography (2008)
  • Author(s): Sakuhara, Y, et. al.
  • Journal Title: Abdom Imaging (In press)
  • Peer Reviewed
• [Journal Article] Transcatheter arterial embolization with absolute ethanol injection for enlarged polycystic kidneys after failed metallic coil embolization (2008)
  • Author(s): Sakuhara, Y., Kato, F., Abo, D., Hasegawa, Y., Shimizu, T., Terae, S., Shirato, H
  • Journal Title: J Vasc Interv Radiol 19(2) Pages: 267-271
  • Peer Reviewed
• [Journal Article] Intercepting radiotherapy using a real-time tumor-tracking radiotherapy system for highly selected patients with hepatocellular carcinoma unresectable with other modalities (2007)
  • Author(s): Taguchi H., et al
  • Journal Title: International Journal of Radiation Oncology Biology Physics 69(2) Pages: 376-380
  • Peer Reviewed
• [Journal Article] Organ motion in image-guided radiotherapy:lessons from real-time tumor-tracking radiotherapy (2007)
  • Author(s): Shirato, H., Shimizu, S., Kitamura, K., Onimaru, R
  • Journal Title: International Journal of Clinical Oncology 12(1) Pages: 8-16
  • Peer Reviewed
• [Journal Article] Experience of high-dose-rate brachytherapy for head and neck cancer treated by a customized intraoral mold technique (2007)
  • Author(s): Obinata, K., Ohmori, K., Shirato, K., Nakamura, M
  • Journal Title: Radiat Med May;25(4) Pages: 181-186
  • Peer Reviewed
• [Journal Article] Hypofractionated stereotactic radiotherapy(HypoFXSRT)for stage I non-small cell lung cancer:updated results of 257 patients in a Japanese multi-institutional study (2007)
  • Author(s): Onishi, H., Shirato, H., Nagata, Y., Hiraoka, M., Fujino, M., Gomi, K., Niibe, Y., Karasawa, K., Hayakawa, K., Takai, Y., Kimura, T., Takeda, A., Ouchi, A., Hareyama, M., Kokubo, M., Hara, R., Itami, J., Yamada, K., Araki, T
  • Journal Title: J Thorac Oncol 2(7 Suppl3) Pages: 94-100
  • Peer Reviewed
• [Journal Article] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone (2007)
  • Author(s): Aoyama, H., Tago, M., Kato, N., Toyoda, T., Kenjyo, M., Hirota, S., Shioura, H., Inomata, T., Kunieda, E., Hayakawa, K., Nakagawa, K., Kobashi, G., Shirato, H
  • Journal Title: Int J Radiat Oncol Biol Phys 1;68(5) Pages: 1388-1395
  • Peer Reviewed
• [Journal Article] Derivation of the tumor position from external respiratory surrogates with periodical updating of the internal/external correlation. (2007)
  • Author(s): Kanoulas, E., Aslam, JA., Sharp, GC., Berbeco, RI., Nishioka, S., Shirato, H., Jiang, SB
  • Journal Title: Phys Med Biol 7;52(17) Pages: 5443-5456
  • Peer Reviewed
• [Journal Article] Accuracy of tumor motion compensation algorithm from a robotic respiratory tracking system:a simulation study (2007)
  • Author(s): Sakuhara, Y., Shimizu, T., Abo, D., Hasegawa, Y., Kato, F., Kodama, Y., Shirato, H.
  • Journal Title: Cardiovasc Intervent Radiol 30(6) Pages: 1201-1205
  • Peer Reviewed
• [Journal Article] Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. (2007)
  • Author(s): Kamiyama, T., Nakanishi, K., Yokoo, H., Tahara, M., Nakagawa, T., Kamachi, H., Taguchi, H., Shirato, H., Matsushita, M., Todo, S
  • Journal Title: Int J Clin Oncol 12(5) Pages: 363-368
  • Peer Reviewed
• [Journal Article] Matrixmetalloproteinases:up-regulated in subclones that survived 10-Gy irradiation. (2007)
  • Author(s): Nishioka, T., Yasuda, M., Tsutsumi, K., Haga, H., Shirato, H
  • Journal Title: Radiat Med 25(8) Pages: 430-431
  • Peer Reviewed
• [Journal Article] Combination tumor immunotherapy with radiotherapy and Thl cell therapy against murine lung carcinoma (2007)
  • Author(s): Yokouchi, H., Chamoto, K., Wakita, D., Yamazaki, K., Shirato, H., Takeshima, T., Dosaka-Akita, H., Nishimura, M., Yue, Z., Kitamura, H., Nishimura, T.
  • Journal Title: Clin Exp Metastasis 24(7) Pages: 533-540
  • Peer Reviewed
• [Journal Article] Adaptive prediction of respiratory motion for motion compensation radiotherapy (2007)
  • Author(s): Ren, Q., Nishioka, S., Shirato, H., Berbeco, RI
  • Journal Title: Phys Med Biol 52(22) Pages: 6651-6661
  • Peer Reviewed
• [Journal Article] Influence of surgical staples on radiofrequency ablation using multitined expandable electrodes (2007)
  • Author(s): Sakuhara, Y., Shimizu, T., Abo, D., Hasegawa, Y., Kato, F., Kodama, Y., Shirato, H
  • Journal Title: Cardiovasc Intervent Radiol 30(6) Pages: 1201-1205
  • Peer Reviewed
• [Journal Article] A novel and efficient synthesis of[2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy. (2007)
  • Author(s): Seki, K, et. al.
  • Journal Title: J Pharm Pharmaceut Sci 10(2) Pages: 212-216
  • Peer Reviewed
• [Journal Article] Extensive FDG uptake and its modification with corticosteroid in a granuloma rat model: an experimental study for differentiating granuloma from tumors. (2007)
  • Author(s): Zhao, S, et. al.
  • Journal Title: Eur Nucl Med Mol Imaging 34(12) Pages: 2096-2105
  • Peer Reviewed
• [Journal Article] Contrast-enhanced FLAIR imaging in combination with pre-and postcontrast magnetization transfer T1-weighted imaging: usefulness in the evaluation of brain metastases. (2007)
  • Author(s): Terae, S, et. al.
  • Journal Title: J Magn Reson Imaging 25(3) Pages: 479-87
  • Peer Reviewed
• [Journal Article] 急性可逆性パーキンソニズムを呈した糖尿病性腎症による維持血液透析の2例 (2007)
  • Author(s): 前野七門・中西正一郎・神田孝一・静川裕彦・辻 幸子・寺江 聡・大越隆一・竹山吉博・作田剛規・松村欣也
  • Journal Title: 透析会誌 40(11) Pages: 919-924
  • Peer Reviewed
• [Journal Article] Neurocognitive function of patents with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone (2007)
  • Author(s): Aoyama, H, et. al.
  • Journal Title: International Journal of Radiation Oncology Biology Physics 68(5) Pages: 1388-1395
  • Peer Reviewed
• [Journal Article] 転移性脳腫瘍に対する放射線治療の役割 (2007)
  • Author(s): 青山英史
  • Journal Title: Jpn J Neurosurg (Tokyo) 16 Pages: 828-832
  • Peer Reviewed
• [Journal Article] 北大45MeV小型電子加速器を用いた最近の研究 (2007)
  • Author(s): 鬼柳善明, 他
  • Journal Title: 加速器 4(2) Pages: 123-130
• [Presentation] 動体追跡照射を目指したFDG計測システムの可能性検証 (2007)
  • Author(s): 原裕, 他
  • Organizer: 日本医学物理学会
  • Place of Presentation: 横浜,パシフィコ横浜
  • Year and Date: 20074013
• [Presentation] Development ofPerfusion Mismatch Analyzer (PMA):Fully Automated,Operator-Independent and Standardized PWI-DWI Analysis Software (2007)
  • Author(s): Kudo K.Sasaki M.Momoshima S.Yamada K.Terae S.Shirato H
  • Organizer: 93rd RSNA scientific assembly and annual meeting
  • Place of Presentation: シカゴ市,マコーミックプレイス
  • Year and Date: 20071125-20071130
• [Presentation] 転移性脳腫瘍への放射線治療後の認知機能変化(JROSG99-1) (2007)
  • Author(s): 青山英史、加藤徳雄、白土博樹、JROSG99-1グループ
  • Organizer: 第117回日本医学放射線学会北日本地方会
  • Place of Presentation: 仙台,艮陵会館
  • Year and Date: 20071116-17
• [Presentation] Low-Dose Craniospinal Irradiation (CSI) With Computed Tomographic (CT) (2007)
  • Author(s): H. Taguchi, K. Yasuda, Y. Sawamura, J. Ikeda, K. Fujieda, Y. Iwasaki and H. Shirato
  • Organizer: 49th annual meeting of ASTRO
  • Place of Presentation: Los Angeles,Los Angeles convention center
  • Year and Date: 20071026-1101
• [Presentation] 細胞の増殖脳の評価及び腫瘍と肉芽腫の鑑別診断における11C-メチオニンの有用性:18F-FDGとの比較 (2007)
  • Author(s): 趙 松吉, 久下裕司, 小華和柾志, 趙 芫, 鐘ヶ江香久子, 関 興一, 玉木長良
  • Organizer: 第2回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 福井 福井フェニックスプラザ
  • Year and Date: 20070628-29
• [Presentation] Explicit Time Domain Boundary Element Scheme for Dispersion-free Wake Field Calculation of long Accelerator Structures (2007)
  • Author(s): K.Fujita, et. al.
  • Organizer: Particle Accelerator Conf
  • Place of Presentation: Albuquerque Convention Center,Albuquerque,New Mexico,USA
  • Year and Date: 20070625-29
• [Presentation] Multi-institutional prospective randomized comparison of stereotactic radiosurgery plus upfront whole brain radiation therapy versus stereotactic radiosurgery alone for the treatment of solitary and multiple brain metastases. (2007)
  • Author(s): Aoyama H.
  • Organizer: 8th International Stereotactic Radiosurgery Society Congress
  • Place of Presentation: San Francisco,パレスホテル
  • Year and Date: 20070623-27
• [Presentation] Dependency of the Venous Phase Shift Upon Positioning Angle in Susceptibility Weighted Imaging (2007)
  • Author(s): IshizakaK.KudoK.YoshidaY.OkaM.Terae S.
  • Organizer: 15th ISMRM (International Society for Magnetic Resonance in Medicine)
  • Place of Presentation: Berlin,Germany ICC berlin
  • Year and Date: 20070518-20070524
• [Presentation] 放射線治療の役割、Plenary Session「転移性脳腫瘍の治療」 (2007)
  • Author(s): 青山 英史
  • Organizer: 第27回日本脳神経外科コングレス総会
  • Place of Presentation: 仙台,サンプラザ
  • Year and Date: 20070518-20
• [Presentation] Stereotactic Radiosurgery Plus Whole-Brain Radiation therapy vs Stereotactic Radiosurgery alone for Treatment of Brain Metastases:A Randomized Control Trial. (2007)
  • Author(s): 青山 英史
  • Organizer: 日本医学放射線学会
  • Place of Presentation: 横浜,パシフィコ横浜
  • Year and Date: 20070412-14
• [Presentation] 3H-FLTによる癌の分子標的療法の早期評価:胆がんマウスにおける投与量依存性の検討 (2007)
  • Author(s): 趙 松吉, 久下裕司, 趙 芫, 竹井俊樹, 鐘ヶ江香久子, 犬伏正幸, 志賀 哲, 加藤千恵次, 関 興一, 玉木長良
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台,仙台国際センター
  • Year and Date: 2007-11-05
• [Presentation] 細胞増殖能評価、腫瘍一肉芽腫の鑑別診断における11C-methionineと18F-FDGの比較 (2007)
  • Author(s): 趙 松吉, 久下裕司, 趙 芫, 竹井俊樹, 加藤誠一, 鐘ヶ江香久子, 岡本祥三, 加藤千恵次, 関 興一, 玉木長良
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台,仙台国際センター
  • Year and Date: 2007-11-04
• [Presentation] Feasibility study of a real-time tumor-tracking system for radiotherapy based on annihilation gamma rays detection from radiopharaceutical concentrateed in a tumor. (2007)
  • Author(s): J.H.Kaneko, et. al.
  • Organizer: IEEE nuclear science symposium and medical imaging conference
  • Place of Presentation: Hqwaii,Hilton Hawaiin Village Beach Resort@Spa
  • Year and Date: 2007-11-03
• [Presentation] Window技術を用いた時間領域境界要素法による粒子加速器航跡場の大規模並列計算 (2007)
  • Author(s): 藤田和広, 他
  • Organizer: 電子情報通信学会技術報告
  • Place of Presentation: 室蘭工業大学,室蘭
  • Year and Date: 2007-08-02
• [Presentation] 18F-FLT but not 18F-FDG can early and dose-dependently detect antiproliferative responses of human tumor xenograft to epidermal growth factor receptor targeting with a tyrosine kinase inhibitor, gefitinib (2007)
  • Author(s): Zhao S, Kuge Y, Zhao Y, Takei T, Kanegae K. Inubushi M, Shiga T, Seki K, Tamaki N
  • Organizer: The 54th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Washington DC ワシントン条約センター
  • Year and Date: 2007-06-04
• [Presentation] Usefulness of^<11>C-methionine in evaluating cellular proliferation and differential diagnosis of tumor and granuloma:An experimental study in comparison with 18F-FDG (2007)
  • Author(s): Zhao S, Kuge Y, Kohanawa M, Zhao Y, Kanegae K, Seki K, Tamaki N
  • Organizer: The 54th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Washington DC ワシントン条約センター
  • Year and Date: 2007-06-03
• [Remarks]
  • URL: http://rad.med.hokudai.ac.jp/research/curing/research_progress/fdsr.php
• [Patent(Industrial Property Rights)] 動的腫瘍の放射線治療装置および動的腫瘍の放射線治療プログラム (2008)
  • Inventor(s): 金子 純一, 他
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: 特願2007-041373PCT/JP2008/052944
  • Filing Date: 2008-02-20
  • Overseas