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2009 Fiscal Year Final Research Report

Basic Research for four-dimensional stereotactic radiotherapy

Research Project

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Project/Area Number 17016002
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHokkaido University

Principal Investigator

SHIRATO Hiroki  Hokkaido University, 大学院・医学研究科, 教授 (20187537)

Co-Investigator(Kenkyū-buntansha) KANEKO Junichi  北海道大学, 大学院・工学研究科, 准教授 (90333624)
NISHIYAMA Syusuke  北海道大学, 大学院・工学研究科, 助教 (30333628)
KATOH Chietsugu  北海道大学, 大学院・保健科学研究院, 准教授 (10292012)
AOYAMA Hidefumi  北海道大学, 大学院・医学研究科, 准教授 (80360915)
SEKI Koh-ichi  北海道大学, アイソトープ総合センター, 教授 (60094835)
ONIMARU Rikiya  北海道大学, 北海道大学病院, 助教
NISHIOKA Takeshi  北海道大学, 大学院・保健科学研究院, 教授 (80271659)
MORITA Koichi  北海道大学, 大学院・医学研究科, 助手 (20210172)
DATE Hiroyuki  北海道大学, 大学院・保健科学研究院, 教授 (10197600)
TAKADA Eiji  富山工業高等専門学校, 電気工学科, 准教授 (00270885)
TOMIOKA Satoshi  北海道大学, 大学院・工学研究科, 准教授 (40237110)
KUDO Kohsude  岩手医科大学, 先端医療研究センター, 講師 (10374232)
Co-Investigator(Renkei-kenkyūsha) ONODERA Yuya  北海道大学, 北海道大学病院, 講師 (10272064)
KAMISHIMA Tamotsu  北海道大学, 北海道大学病院, 講師 (10399868)
ONIMARU Rikiya  北海道大学, 北海道大学病院, 助教 (80374461)
SHIMIZU Shinichi  北海道大学, 大学院・医学研究科, 特任講師 (50463724)
SAKUHARA Yusuke  北海道大学, 北海道大学病院, 助教 (40374459)
OYAMA Noriko  北海道大学, 北海道大学病院, 助教 (70463742)
ABO Daisuke  北海道大学, 北海道大学病院, 助教 (30399844)
TAGUCHI Hiroshi  北海道大学, 北海道大学病院, 助教 (90374454)
Project Period (FY) 2005 – 2009
Keywords放射線治療 / 核医学診断技術 / 動体追跡放射線治療 / スポットスキャン / 低酸素細胞 / 画像誘導放射線治療
Research Abstract

We developed a four-dimensional (4-D, space and time) focal positron emission localizer, FPEL, using two sets of BGO scintillators, photo-electric multiplier, and collimators. A narrow (5-mm in diameter) 45-MeV electron beam was controlled to irradiate a target with an accuracy of 0.1mm in 4D coordinates automatically if the amount of positron emitters at the target exceeds the threshold. A mouse model was established to irradiate the tumor in which FDG is accumulated. Using the FPEL, 45-MeV electron beam hit the tumor in mice which move in front of the beam exit with the amplitude resembling human respiration. Tumor without fiducial gold marker disappeared within a week after the irradiation. Basis for 4D stereotacic radiotherapy was established successfully.

  • Research Products

    (20 results)

All 2009 2008 2007 2006 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Three-dimensional Wake Field Computations based on Scattered-field Time Domain Boundary Element Method.2009

    • Author(s)
      Fujita K, Kawaguchi H, Weil, T, Tomioka S
    • Journal Title

      IEEE Transactions on Nuclear Science 56(4)

      Pages: 2341-2350

    • Peer Reviewed
  • [Journal Article] Difference in the Tracer Delay-Induced Effect among Deconvolution Algorithms in CT Perfusion Analysis: Quantitative Evaluation by using Digital Phantoms.2009

    • Author(s)
      Kudo K, Sasaki M, Ogasawara K, Terae S, Ehara S, Shirato H
    • Journal Title

      Radiology 251(1)

      Pages: 241-249

    • Peer Reviewed
  • [Journal Article] Novel function of transcription factor ATF5: blockade of p53-dependent apoptosis induced by ionizing irradiation.2009

    • Author(s)
      Nishioka T, Miyai Y, Haga H, Kawabata K, Shirato H, Homma A, Shibata K, Yasuda M
    • Journal Title

      Cell Struct Funct. 34(1)

      Pages: 17-22

    • Peer Reviewed
  • [Journal Article] Clinical outcomes of stereotactic body radiotherapy for small lung lesions clinically diagnosed as primary lung cancer on radiologic examination.2009

    • Author(s)
      Inoue T, Shimizu S, Onimaru R, Takeda A, Onishi H, Nagata Y, Kimura T, Karasawa K, Arimoto T, Hareyama M, Kikuchi E, Shirato H
    • Journal Title

      Int J Radiat Oncol Biol Phys. 75(3)

      Pages: 683-687

    • Peer Reviewed
  • [Journal Article] Power Doppler ultrasound of rheumatoid synovitis: quantification of vascular signal and analysis of interobserver variability.2009

    • Author(s)
      Kamishima T, Tanimura K, Henmi M, Narita A, Sakamoto F, Terae S, Shirato H
    • Journal Title

      Skeletal Radiol 38(5)

      Pages: 467-472

    • Peer Reviewed
  • [Journal Article] New [11C]phosgene based [11C] pyrimidines for Positron emission tomography.2008

    • Author(s)
      Seki K, Nishijima K, Sanoki K, Kuge Y, Takahashi M, Akizawa H, Tamaki N, Wiebe L, Ohkura K
    • Journal Title

      Heterocycles 77

      Pages: 1307-1321

    • Peer Reviewed
  • [Journal Article] Splenic peliosis mimicking a solid tumor: findings in multimodalities.2008

    • Author(s)
      Abo D, Terae S, Fukasawa Y, Seki H, Hasegawa Y, Sakuhara Y, Shimizu T, Shirato H
    • Journal Title

      J Comput Assist Tomogr 32

      Pages: 890-892

    • Peer Reviewed
  • [Journal Article] Real-time tumor-tracking radiotherapy for adrenal tumors.2008

    • Author(s)
      Katoh N, Onimaru R, Sakuhara Y, Abo D, Shimizu S, Taguchi H, Watanabe Y, Shinohara N, Ishikawa M, Shirato H
    • Journal Title

      Radiother Oncol 87

      Pages: 418-424

    • Peer Reviewed
  • [Journal Article] Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy.2008

    • Author(s)
      Onimaru R, Fujino M, Yamazaki K, Onodera Y, Taguchi H, Katoh N, Hommura F, Oizumi S, Nishimura M, Shirato H
    • Journal Title

      Int J Radiat Oncol Biol Phys. 70(2)

      Pages: 374-381

    • Peer Reviewed
  • [Journal Article] Exhale fluctuation in respiratory-gated radiotherapy of the lung: A pitfall of respiratory gating shown in a synchronized internal/external marker recording study.2008

    • Author(s)
      Nishioka S, Nishioka T, Kawahara M, Tanaka S, Hiromura T, Tomita K, Shirato H
    • Journal Title

      Radiother Oncol 86(1)

      Pages: 69-76

    • Peer Reviewed
  • [Journal Article] Organ motion in image-guided radiotherapy: lessons from real-time tumor-tracking radiotherapy.2007

    • Author(s)
      Shirato H, Shimizu S, Kitamura K, Onimaru R
    • Journal Title

      Int J Clin Oncol. 12(1)

      Pages: 8-16

    • Peer Reviewed
  • [Journal Article] Influence of surgical staples on radiofrequency ablation using multitined expandable electrodes.2007

    • Author(s)
      Sakuhara Y, Shimizu T, Abo D, Hasegawa Y, Kato F, Kodama Y, Shirato H
    • Journal Title

      Cardiovasc Intervent Radiol 30(6)

      Pages: 1201-1205

    • Peer Reviewed
  • [Journal Article] Intercepting radiotherapy using a real-time tumor-tracking radiotherapy system for highly selected patients with hepatocellular carcinoma unresectable with other modalities.2007

    • Author(s)
      Taguchi H, Sakuhara Y, Hige S, Kitamura K, Osaka Y, Abo D, Uchida D, Sawada A, Kamiyama T, Shimizu T, Shirato H, Miyasaka K
    • Journal Title

      Int J Radiat Oncol Biol Phys. 69(2)

      Pages: 376-380

    • Peer Reviewed
  • [Journal Article] Contrast-enhanced FLAIR imaging in combination with pre- and postcontrast magnetization transfer T1-weighted imaging: usefulness in the evaluation of brain metastases.2007

    • Author(s)
      Terae S, Yoshida D, Kudo K, Tha KK, Fujino M, Miyasaka K
    • Journal Title

      J Magn Reson Imaging 25(3)

      Pages: 479-87

    • Peer Reviewed
  • [Journal Article] 北大45MeV小型電子加速器を用いた最近の研究"加速器2007

    • Author(s)
      鬼柳善明, 他
    • Journal Title

      4(2)

      Pages: 123-130

  • [Journal Article] Speed and amplitude of lung tumor motion precisely detected in four-dimensional setup and in real-time tumor-tracking radiotherapy.2006

    • Author(s)
      Shirato H, Suzuki K, Sharp GC, Fujita K, Onimaru R, Fujino M, Kato N, Osaka Y, Kinoshita R, Taguchi H, Onodera S, Miyasaka K
    • Journal Title

      Int J Radiat Oncol Biol Phys. 15;64(4)

      Pages: 1229-1236

    • Peer Reviewed
  • [Presentation] 定位放射線治療のための消滅γ線計測に基づく腫瘍位置同定装置の概念設計2009

    • Author(s)
      原裕、島崎紘亘、金子純一、高田英治、藤田文行、久保直樹、石川正純、本間彰、古坂道弘、白土博樹
    • Organizer
      第97回日本医学物理学会総会
    • Place of Presentation
      横浜, パシフィコ横浜
    • Year and Date
      20090416-20090418
  • [Remarks]

    • URL

      http://rad.med.hokudai.ac.jp/

  • [Patent(Industrial Property Rights)] 動的腫瘍の放射線治療装置および動的腫瘍の放射線治療プログラム2008

    • Inventor(s)
      金子純一, 他
    • Industrial Property Rights Holder
      北海道大学、国立高等専門学校機構
    • Industrial Property Number
      特許権・特願2007-041373 PCT/JP2008/052944
    • Filing Date
      2008-02-20
    • Overseas
  • [Patent(Industrial Property Rights)] 医療用画像処理システム2007

    • Inventor(s)
      加藤千恵次
    • Industrial Property Rights Holder
      加藤千恵次
    • Industrial Property Number
      特許権・P2006-242
    • Filing Date
      2007-02-23

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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