Cancer therapy using labeled antibodies

2009 Fiscal Year Final Research Report

• Project/Area Number: 17016008
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Gunma University
• Principal Investigator: ENDO Keigo Gunma University, 大学院・医学系研究科, 教授 (10115800)
• Co-Investigator(Kenkyū-buntansha): ORIUCHI Noboru 群馬大学, 大学院・医学系研究科, 准教授 (40292586) ; IIDA Yasuhiko 鈴鹿医療科学大学, 薬学部, 教授 (60252425) ; ARANO Yasushi 千葉大学, 大学院・薬研究院, 教授 (90151167) ; TSUSHIMA Yoshito 群馬大学, 医学部, 講師 (20375546)
• Project Period (FY): 2004 – 2009
• Keywords: 抗体 / 放射性同位元素 / がん / 放射線治療

Research Abstract

Antibodies cancer-associated antigens were selected and labeled with various radionuclides. In tumor-bearing mice, radiolabeled antibody showed a high accumulation in the tumor and clear PET images of the tumor. In therapeutic study using 90Y-labeled antibody, slow progression of tumor was observed and substantial tumor size reduction was also observed in some cases. These results indicated usefulness of the cancer therapy using radiolabed antibodies, and new labeled antibodies were developed useful for the therapy of cancer.

Research Products

• [Journal Article] (2009)
  • Author(s): Hanaoka H, Katagiri T, Fukukawa C, Yoshioka H, Yamamoto S, Iida Y, Higuchi T, Oriuchi N, Paudyal B, Paudyal P, Nakamura Y, Endo K
  • Journal Title: Ann Nucl Med 23 Pages: 479-485
  • Peer Reviewed
• [Journal Article] Evaluation of (64)Cu-labeled DOTA-D-Phe(1)-Tyr (3)-octreotide ((64)Cu-DOTA-TOC) for imaging somatostatin receptor-expressing tumors. (2009)
  • Author(s): Hanaoka H, Tominaga H, Yamada K, Paudyal P, Iida Y, Watanabe S, Paudyal B, Higuchi T, Oriuchi N, Endo K
  • Journal Title: Ann Nucl Med 23 Pages: 559-67
  • Peer Reviewed
• [Journal Article] 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer. (2009)
  • Author(s): Kaira K, K, Oriuchi N, Shimizu K, Tominaga H, Yanagitani N, Sunaga N, Ishizuka T, Kanai Y, Mori M, Endo K
  • Journal Title: J Nucl Med 50 Pages: 1770-6
  • Peer Reviewed
• [Journal Article] The clinical application of (18)F-fluorodeoxyglucose positron emission tomography to predict survival in patients with operable esophageal cancer. (2009)
  • Author(s): Kato H, Nakajima M, Sohda M, Tanaka N, Inose T, Miyazaki T, Fukuchi M, Oriuchi N, Endo K, Kuwano H
  • Journal Title: Cancer 115 Pages: 3196-203
  • Peer Reviewed
• [Journal Article] Dual functional molecular imaging probe targeting CD20 with PET and optical imaging. (2009)
  • Author(s): Paudyal P, Paudyal B, Iida Y, Oriuchi N, Hanaoka H, Tominaga H, Ishikita T, Yoshioka H, Higuchi T, Endo K
  • Journal Title: ONCOLOGY REPORTS 22 Pages: 115-119
  • Peer Reviewed
• [Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. (2008)
  • Author(s): Fukukawa C, Hanaoka H, Nagayama S, Tsunoda T, Toguchida J, Endo K, Nakamura Y, Katagiri T
  • Journal Title: Cancer Sci 99 Pages: 432-440
  • Peer Reviewed
• [Journal Article] Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer. (2008)
  • Author(s): Sunaga N, Oriuchi, N, Kaira K, Yanagitani N, Tomizawa Y, Hisada T, Ishizuka T, Endo K, Mori M
  • Journal Title: Lung Cancer 59 Pages: 203-210
  • Peer Reviewed
• [Journal Article] Patlak plot analysis for assessment of single-kidney glomerular filtration rate (GFR) with dynamic CT. (2008)
  • Author(s): Tsushima Y, Taketomi-Takahashi A, Endo K
  • Journal Title: Radiology 246 Pages: 336-338
  • Peer Reviewed
• [Journal Article] Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma. (2008)
  • Author(s): Paudyal B, Paudyal P, Oriuchi N, Tsushima Y, Nakajima T, Endo K
  • Journal Title: Int J Oncol 33 Pages: 1047-1054
  • Peer Reviewed
• [Journal Article] he usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and a comparison of 18F-FDG-PET with 67gallium scintigraphy in the evaluation of lymphoma. (2007)
  • Author(s): Tsukamoto N, Kojima M, Hasegawa M, Oriuchi N, Matsushima T, Yokohama A, Saitoh T, Handa H, Endo K, Murakami H
  • Journal Title: Cancer 110 Pages: 652-659
  • Peer Reviewed
• [Journal Article] Design, synthesis, and evaluation of [188Re] organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels. (2007)
  • Author(s): Uehara T, Koide M, Nakata H, Hanaoka H, Iida Y, Hashimoto K, AkizawaH, Endo K, Arano Y
  • Journal Title: Bioconjug Chem 18 Pages: 190-198
  • Peer Reviewed
• [Journal Article] Prediction of response to definitive chemoradiotherapy in esophageal cancer using positron emission tomography. (2007)
  • Author(s): Kato H, Fukuchi M, Miyazaki T, Nakajima M, Tanaka N, Inose T, Kimura H, Faried A, Saito K, Sohda M, Fukai Y, Masuda N, Manda R, Ojima H, Tsukada K, Oriuchi N, Endo K, Nonaka T, Shioya M, Ishikawa H, Sakurai H, Nakano T, Kuwano H
  • Journal Title: Anticancer Res 27 Pages: 2627-2633
  • Peer Reviewed
• [Journal Article] Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy. (2007)
  • Author(s): Paudyal B, Oriuchi N, Paudyal P, Tsushima Y, Iida Y, Higuchi T, Hanaoka H, Miyakubo M, Takano A, Ishikita T, Endo K
  • Journal Title: Oncology Reports 18 Pages: 1469-1473
  • Peer Reviewed
• [Journal Article] Inverse correlation between tumor perfusion and glucose uptake in human head and neck tumors. (2007)
  • Author(s): Hirasawa S, Tsushima Y, Takei H, Hirasawa H, Taketomi-Takahashi A, Takano A, Oriuchi N, Endo K
  • Journal Title: Acad Radiol 14 Pages: 312-318
  • Peer Reviewed
• [Journal Article] Present role and future prospect of positron emission tomography in clinical oncology. (2006)
  • Author(s): Oriuchi N, Higuchi T, Ishikita T, Miyakubo M, Hanaoka H, lida Y, Endo K
  • Journal Title: Cancer Sci 97 Pages: 1291-1297
  • Peer Reviewed
• [Journal Article] A phase I redioimmunolocalization trial of humanized monoclonal antibody huA33 in patients with gastric carcinoma. (2006)
  • Author(s): Sakamoto J, Oriuchi N, Mochiki E, Asao T, Scott AM, Hoffman EW, Jungbluth AA, Matsui T, Lee FT, Papenfuss A, Kuwano H, Takahashi T, Endo K, Old LJ
  • Journal Title: Cancer Science 97 Pages: 1248-1254
  • Peer Reviewed
• [Journal Article] MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images: is it useful for differentiation from medulloblastoma? (2006)
  • Author(s): Arai K, Sato N, Aoki J, Yagi A, Taketomi-Takahashi A, Morita H, Koyama Y, Oba H, Ishiuchi S, Sato N, Endo K
  • Journal Title: Neuroradiology 48 Pages: 233-237
  • Peer Reviewed
• [Journal Article] PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients. (2006)
  • Author(s): Endo K, Oriuchi N, Higuchi T, Iida Y, Hanaoka H, Miyakubo M, Ishikita T, Koyama K
  • Journal Title: Int J Clin Oncol 11 Pages: 286-296
  • Peer Reviewed
• [Journal Article] Current status of cancer therapy with radiolabeled monoclonal antibody. (2005)
  • Author(s): Oriuchi N, Higuchi T, Hanaoka H, Iida Y, Endo K.
  • Journal Title: Annals of Nuclear Medicine 19 Pages: 355-365
  • Peer Reviewed
• [Journal Article] Morphological imaging in the localization of neuroendocrine gastroenteropancreatic tumors found by somatostatin receptor scintigraphy. (2005)
  • Author(s): Saga T, Shimatsu A, Koizumi K, Ichikawa T, Yamamoto K, Noguchi S, Doi R, Ishibashi M, Machinami R, Nakamura K, Sakahara H, Endo K.
  • Journal Title: Acta Radiol 46 Pages: 227-232
  • Peer Reviewed
• [Journal Article] MR imaging in the evaluation of chronic or recurrent headache. (2005)
  • Author(s): Tsushima Y, Endo K
  • Journal Title: Radiology 235 Pages: 575-579
  • Peer Reviewed
• [Journal Article] Phase I study of radioimmunotherapy with an anti-CD20 murine radioimmunoconjugate (90Y-ibritumomab tiuxetan) in relapsed or refractory indolent B-cell lymphoma. (2005)
  • Author(s): Watanabe Watanabe T, Terui S, Itoh K, Terauchi T, Igarashi T, Usubuchi N, Nakata M, Nawano S, Sekiguchi N, Kusumoto S, Tanimoto K, Kobayashi Y, Endo K, Seriu T, Hayashi., Tobinai K
  • Journal Title: Cancer Sci 96 Pages: 903-910
  • Peer Reviewed
• [Journal Article] In vitro system to estimate renal brush border enzyme-mediated cleavage of peptide linkages for designing radiolabeled antibody fragments of low renal radioactivity levels. (2005)
  • Author(s): Fujioka Y, Satake S, Uehara T, Mukai T, Akizawa H, Ogawa K, Saji H, Endo K, Arano Y
  • Journal Title: Bioconjugate Chemistry 16 Pages: 1610-1616
  • Peer Reviewed
• [Presentation] FDG-PET in gastrointestinal tumor. (2010)
  • Author(s): Endo K
  • Organizer: フィリピン核医学会特別講演
  • Place of Presentation: フィリピン国マニラ市
  • Year and Date: 2010-02-06
• [Presentation] FDG-PET for cancer in Japan (2008)
  • Author(s): Endo K
  • Organizer: 英国核医学会特別講演
  • Place of Presentation: 日英国エディンバラ市
  • Year and Date: 2008-05-13
• [Presentation] 抗体を用いる癌治療の現状とRI標識抗体の利用 (2007)
  • Author(s): 遠藤啓吾
  • Organizer: 日本癌学会総会シンポジウム
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-10-04
• [Presentation] New imaging technique for the oral and maxilla-facial region. (2005)
  • Author(s): Endo K
  • Organizer: 国際口腔外科学特別講演
  • Place of Presentation: 群馬県前橋市
  • Year and Date: 2005-06-11
• [Presentation] Current status of PET in Japan. (2005)
  • Author(s): Endo K.
  • Organizer: オーストラリア核医学会特別講演
  • Place of Presentation: オーストラリア国メルボルン市
  • Year and Date: 2005-04-30
• [Patent(Industrial Property Rights)] ANTI-CDH3 ANTIBODIES AND USES THEREOF (2009)
  • Inventor(s): 遠藤啓吾
  • Industrial Property Rights Holder: 群馬大学、東京大学、オンコテラピーサイエンス(株)
  • Industrial Property Number: 特許・PCT/JP2009/007333
  • Filing Date: 2009-12-28
• [Patent(Industrial Property Rights)] ANTI-DSC2 ANTIBODIES LABELED WITH RADIOISOTOPE LABEL AND USES THEREOF (2009)
  • Inventor(s): 遠藤啓吾
  • Industrial Property Rights Holder: 権利者:群馬大学、東京大学、オンコテラピーサイエンス(株)
  • Industrial Property Number: 米国仮出願・60/225, 428
  • Filing Date: 2009-07-14
• [Patent(Industrial Property Rights)] ANTI-CDH3 ANTIBODIES LABELED WITH RADOISOTOPE LABEL AND USES THEREOF (2009)
  • Inventor(s): 遠藤啓吾
  • Industrial Property Rights Holder: 群馬大学、東京大学、オンコテラピーサイエンス(株)
  • Industrial Property Number: 特許・PCT/JP2009/003009
  • Filing Date: 2009-06-30
• [Patent(Industrial Property Rights)] 抗体標識が可能な無担体177Luの分離精製法 (2009)
  • Inventor(s): 遠藤啓吾
  • Industrial Property Rights Holder: 群馬大学、独立行政法人日本原子力研究開発機構
  • Industrial Property Number: 特許・特願2009-072558
  • Filing Date: 2009-03-24
• [Patent(Industrial Property Rights)] TUMOR-TARGETING MONOCLONAL ANTIBODIES TO FZD10 AND USES THEREOF (2006)
  • Inventor(s): 遠藤啓吾
  • Industrial Property Rights Holder: 群馬大学、東京大学、オンコテラピーサイエンス(株)
  • Industrial Property Number: 特許・TC/JP2006/317155
  • Filing Date: 2006-08-24