2009 Fiscal Year Final Research Report
Cancer therapy using labeled antibodies
Project/Area Number |
17016008
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Gunma University |
Principal Investigator |
ENDO Keigo Gunma University, 大学院・医学系研究科, 教授 (10115800)
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Co-Investigator(Kenkyū-buntansha) |
ORIUCHI Noboru 群馬大学, 大学院・医学系研究科, 准教授 (40292586)
IIDA Yasuhiko 鈴鹿医療科学大学, 薬学部, 教授 (60252425)
ARANO Yasushi 千葉大学, 大学院・薬研究院, 教授 (90151167)
TSUSHIMA Yoshito 群馬大学, 医学部, 講師 (20375546)
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Project Period (FY) |
2004 – 2009
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Keywords | 抗体 / 放射性同位元素 / がん / 放射線治療 |
Research Abstract |
Antibodies cancer-associated antigens were selected and labeled with various radionuclides. In tumor-bearing mice, radiolabeled antibody showed a high accumulation in the tumor and clear PET images of the tumor. In therapeutic study using 90Y-labeled antibody, slow progression of tumor was observed and substantial tumor size reduction was also observed in some cases. These results indicated usefulness of the cancer therapy using radiolabed antibodies, and new labeled antibodies were developed useful for the therapy of cancer.
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[Journal Article]2009
Author(s)
Hanaoka H, Katagiri T, Fukukawa C, Yoshioka H, Yamamoto S, Iida Y, Higuchi T, Oriuchi N, Paudyal B, Paudyal P, Nakamura Y, Endo K
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Journal Title
Ann Nucl Med 23
Pages: 479-485
Peer Reviewed
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[Journal Article] 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer.2009
Author(s)
Kaira K, K, Oriuchi N, Shimizu K, Tominaga H, Yanagitani N, Sunaga N, Ishizuka T, Kanai Y, Mori M, Endo K
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Journal Title
J Nucl Med 50
Pages: 1770-6
Peer Reviewed
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[Journal Article] Design, synthesis, and evaluation of [188Re] organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels.2007
Author(s)
Uehara T, Koide M, Nakata H, Hanaoka H, Iida Y, Hashimoto K, AkizawaH, Endo K, Arano Y
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Journal Title
Bioconjug Chem 18
Pages: 190-198
Peer Reviewed
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[Journal Article] Prediction of response to definitive chemoradiotherapy in esophageal cancer using positron emission tomography.2007
Author(s)
Kato H, Fukuchi M, Miyazaki T, Nakajima M, Tanaka N, Inose T, Kimura H, Faried A, Saito K, Sohda M, Fukai Y, Masuda N, Manda R, Ojima H, Tsukada K, Oriuchi N, Endo K, Nonaka T, Shioya M, Ishikawa H, Sakurai H, Nakano T, Kuwano H
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Journal Title
Anticancer Res 27
Pages: 2627-2633
Peer Reviewed
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[Journal Article] Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy.2007
Author(s)
Paudyal B, Oriuchi N, Paudyal P, Tsushima Y, Iida Y, Higuchi T, Hanaoka H, Miyakubo M, Takano A, Ishikita T, Endo K
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Journal Title
Oncology Reports 18
Pages: 1469-1473
Peer Reviewed
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[Journal Article] A phase I redioimmunolocalization trial of humanized monoclonal antibody huA33 in patients with gastric carcinoma.2006
Author(s)
Sakamoto J, Oriuchi N, Mochiki E, Asao T, Scott AM, Hoffman EW, Jungbluth AA, Matsui T, Lee FT, Papenfuss A, Kuwano H, Takahashi T, Endo K, Old LJ
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Journal Title
Cancer Science 97
Pages: 1248-1254
Peer Reviewed
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[Journal Article] MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images: is it useful for differentiation from medulloblastoma?2006
Author(s)
Arai K, Sato N, Aoki J, Yagi A, Taketomi-Takahashi A, Morita H, Koyama Y, Oba H, Ishiuchi S, Sato N, Endo K
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Journal Title
Neuroradiology 48
Pages: 233-237
Peer Reviewed
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[Journal Article] Morphological imaging in the localization of neuroendocrine gastroenteropancreatic tumors found by somatostatin receptor scintigraphy.2005
Author(s)
Saga T, Shimatsu A, Koizumi K, Ichikawa T, Yamamoto K, Noguchi S, Doi R, Ishibashi M, Machinami R, Nakamura K, Sakahara H, Endo K.
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Journal Title
Acta Radiol 46
Pages: 227-232
Peer Reviewed
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[Journal Article] Phase I study of radioimmunotherapy with an anti-CD20 murine radioimmunoconjugate (90Y-ibritumomab tiuxetan) in relapsed or refractory indolent B-cell lymphoma.2005
Author(s)
Watanabe Watanabe T, Terui S, Itoh K, Terauchi T, Igarashi T, Usubuchi N, Nakata M, Nawano S, Sekiguchi N, Kusumoto S, Tanimoto K, Kobayashi Y, Endo K, Seriu T, Hayashi., Tobinai K
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Journal Title
Cancer Sci 96
Pages: 903-910
Peer Reviewed
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