2009 Fiscal Year Final Research Report
Epitehial-stromal interactions and molecularly targeted therapy
| Project/Area Number |
17016032
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKETO Makoto Kyoto University, 医学研究科, 教授 (70281714)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Masanobu 京都大学, 医学研究科, 准教授 (40324610)
OSHIMA Hiroko 金沢大学, がん研究所, 助教 (80362515)
AOKI Masahiro 京都大学, 医学研究科, 准教授 (60362464)
MIYOSHI Hiroyuki 京都大学, 医学研究科, 助教 (30362479)
KITAMURA Takanori 京都大学, 医学研究科, 助教 (10378622)
SONOSHITA Masahiro 京都大学, 医学研究科, 助教 (80511857)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / 炎症 / 血管新生 / シグナル伝達 / マイクロアレイ |
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| Research Abstract |
Cancer tissues consist of cancer cells and stromal cells, including inflammatory cells and those forming blood vessels. We have shown that MMP7, an enzyme that cancer cells secrete to help degrade the surrounding tissues, enhances the growth of intestinal cancer. We have also found that activation of a signaling complex called mTORC1 enhances blood vessel formation to improve oxygen/nutrient supply to the tumor cells. In addition, our studies have revealed that a signaling pathway called the Wnt pathway plays essential roles in malignant progression of stomach and liver cancers.
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Research Products
(41 results)
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[Journal Article] M. CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium.2010
Author(s)
Kakizaki, F., Aoki, K., Miyoshi, H., Carrasco, N., Aoki, M., Taketo, M.
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Journal Title
Gastroenterology 138
Pages: 627-35
Peer Reviewed
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[Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1 mice.2009
Author(s)
Miyoshi, H., Deguchi, A., Nakau, M., Kojima, Y., Mori, A., Oshima, M., Aoki, M., Taketo, M.M.
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Journal Title
Cancer Sci. 100
Pages: 2046-53
Peer Reviewed
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[Journal Article] Reduced level of Smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.2009
Author(s)
Arimura, S., Matsunaga, A., Kitamura, T., Aoki, K., Aoki, M., Taketo, M.M.
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Journal Title
Gastroenterology 137
Pages: 629-638
Peer Reviewed
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[Journal Article] Matrix metalloproteinase 7 is required for tumor formation, but indispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas.2009
Author(s)
Kitamura, T., Biyajima, K., Aoki, M., Oshima, M., Taketo, M.M.
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Journal Title
Lab. Invest. 89
Pages: 98-105
Peer Reviewed
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[Journal Article] Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity regulating kinases signaling.2007
Author(s)
Kojima, Y., Miyoshi, H., Clevers, H.C., Oshima, M., Aoki, M., Taketo, M.M.
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Journal Title
J. Biol. Chem. 282
Pages: 23532-23540
Peer Reviewed
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[Journal Article] SMAD4-deficient intestinal tumors recruit CCR1+-myeloid cells that help invasion.2007
Author(s)
Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, M., Taketo, M.M.
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Journal Title
Nat. Genet. 39
Pages: 467-475
Peer Reviewed
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[Journal Article] Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes.2007
Author(s)
Kawada, K., Hosogi, H., Sonoshita, M., Sakashita, H., Manabe, T., Shimahara, Y., Sakai, Y., Takabayashi, A, Oshima, M., Taketo, M.M.
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Journal Title
Oncogene 26
Pages: 4679-4688
Peer Reviewed
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[Journal Article] Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells.2007
Author(s)
Aoki, K., Aoki, M., Sugai, M., Harada, N., Miyoshi, H., Tsukamoto, T., Mizoshita, T., Tatematsu, M., Seno, H., Chiba, T., Oshima, M., Hsieh, C.L., Taketo, M.M.
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Journal Title
Oncogene 26
Pages: 3511-3520
Peer Reviewed
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