2009 Fiscal Year Final Research Report
Analysis of human tumor antigens and immune responses in patients
| Project/Area Number |
17016048
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
NAKAYAMA Eiichi Okayama University, 大学院・医歯薬学総合研究科, 教授 (60180428)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ONO Toshiro 岡山大学, 大学院・医歯薬総合研究科, 准教授 (50185641)
UENAKA Akiko 岡山大学, 大学院・医歯薬総合研究科, 講師 (50273967)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Keywords | がん免疫 / がん・精巣(CT)抗原 / 宿主免疫応答 / 免疫回避 / がんワクチン |
|---|
| Research Abstract |
For cancer vaccine, identification of cancer antigens which are highly specific to cancer and strongly immunogenic in cancer patients is necessary. We found that CCDC62, HERV-K and XAGE-1b are cancer antigens which can be used as vaccine. We also conducted a clinical trial of cancer vaccine using a complex of cholesterol hydrophobized pullulan (CHP) and NY-ESO-1 protein. Immune response was elicited after vaccination in patients and some patients showed favorable clinical course.
|
