Functional Genomics based upon mouse inter-subspecific consomic strain

2009 Fiscal Year Final Research Report

• Project/Area Number: 17018033
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute of Genetics
• Principal Investigator: SHIROISHI Toshihiko National Institute of Genetics, 系統生物研究センター, 教授 (90171058)
• Co-Investigator(Kenkyū-buntansha): KOIDE Tsuyoshi 国立遺伝学研究所, 系統生物研究センター, 准教授 (20221955)
• Co-Investigator(Renkei-kenkyūsha): TAKADA Toyoyuki 国立遺伝学研究所, 系統生物研究センター, 助教 (20356257)
• Project Period (FY): 2005 – 2009
• Keywords: C57BL / 6 / MSM / Ms / コンソミック系統 / SNP / ゲノム多型性 / 表現型多様性 / QTL / サブコンソミック系統

Research Abstract

Based upon large genomic and phenotypic differences between two mouse subspecies, we have developed an analytic platform for mouse functional genomics. Systematic phenotyping of a full set of mouse inter-subspecific consomic strains, in which each chromosome of a standard inbred strain C57BL/6J is replaced by its counter part of Japanese wild mice-derived MSM/Ms, successfully detected more than 200 QTLs that affect growth, metabolism, and behavioral complex traits. Beside, we have constructed genome and phenotype databases, integrating SNPs and the QTLs detected by the consomic strains. These databases are now open to public.

Research Products

• [Journal Article] Genetic mapping of social interaction behavior in B6/MSM consomic mouse strains (2010)
  • Author(s): Takahashi, A., Tomihara, K., Shiroishi, T., Koide, T.
  • Journal Title: Behavior Genet 40(in press) Pages: 366-376
  • Peer Reviewed
• [Journal Article] QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains (2009)
  • Author(s): Umemori, J., Nishi, A., Lionikas, A., Sakaguchi, T., Kuriki, S., Blizard, D.A., Koide, T.
  • Journal Title: BMC Genet 10 Pages: 40
  • Peer Reviewed
• [Journal Article] Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits (2008)
  • Author(s): Takada, T., Mita, A., Maeno, A., Sakai, T., Shitara, H., Kikkawa, Y., Moriwaki, K., Yonekawa, H., Shiroishi, T.
  • Journal Title: Genome Res. 18 Pages: 500-508
  • Peer Reviewed
• [Journal Article] Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms (2008)
  • Author(s): Takahashi, A., Nishi, A., Ishii, A., Shiroishi, T., Koide, T.
  • Journal Title: Genes, Brain and Behavior 7 Pages: 849-858
  • Peer Reviewed
• [Journal Article] Multigenic factors associated with a hydrocephalus-like phenotype found in inter-subspecific consomic mouse strains (2008)
  • Author(s): Takahashi, A., Shiroishi, T., Koide, T.
  • Journal Title: Mammal Genome 29 Pages: 333-338
  • Peer Reviewed
• [Journal Article] Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of theμopioid receptor gene in 10 inbred mouse strains. Pharmacogenet (2008)
  • Author(s): Shigeta Y., Kasai S., Han W., Hata H., Nishi A., Takamatsu Y., Hagino Y., Yamamoto H., Koide T., Shiroishi T., Kasai K., Tsunashima K., Kato N., Ikeda K.
  • Journal Title: Genomics 18 Pages: 927-936
  • Peer Reviewed
• [Journal Article] A new Gsdma3 mutation affecting anagen phase of first hair cycle. (2007)
  • Author(s): Tanaka, S., Tamura, M., Aoki, A., Fujii, T., Komiyama, H., Sagai, T., Shiroishi, T.
  • Journal Title: Biochem Biophys Res Commun 359 Pages: 902-907
  • Peer Reviewed
• [Journal Article] Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. (2007)
  • Author(s): Tamura M., Tanaka S., Fujii T., Aoki A., Komiyama H., Ezawa K., Sumiyama K., Sagai T., Shiroishi, T.
  • Journal Title: Genomics 89 Pages: 618-629
  • Peer Reviewed
• [Journal Article] Disruption of Genetic Interaction Between Two Autosomal Regions and the X Chromosome Causes Reproductive Isolation Between Mouse Strains Derived From Different Subspecies (2007)
  • Author(s): Oka, A., Aoto, T., Totsuka, Y., Takahashi, R., Ueda, M., Mita, M., Sakurai-Yamatani, N., Yamamoto, H., Kuriki, S., Takagi, N., et al.
  • Journal Title: Genetics 175 Pages: 185-197
  • Peer Reviewed
• [Journal Article] A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud (2007)
  • Author(s): Masuya, H., Sezutsu, H., Sakuraba, Y., Sagai, T., Hosoya, M., Kaneda, H., Miura, I., Kobayashi, K., Sumiyama, K., Shimizu, A., et al.
  • Journal Title: Genomics 89 Pages: 207-214
  • Peer Reviewed
• [Journal Article] Multivariate Analysis of Temporal Descriptions of Open-field Behavior in Wild-derived Mouse Strains (2006)
  • Author(s): Takahashi, A., Kato, K., Makino, J., Shiroishi, T., Koide, T.
  • Journal Title: Behavioral Genet 36 Pages: 763-774
  • Peer Reviewed
• [Journal Article] Molecular evolution of Cadherin-related neuronal receptor/protocadherinα(CNR/Pcdhα) gene cluster in Mus musculus subspecies (2005)
  • Author(s): Taguchi, Y., Koide, T., Shiroishi, T., Yagi, T.
  • Journal Title: Mol. Biol. Evol. 22 Pages: 1433-1443
  • Peer Reviewed
• [Journal Article] Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains (2005)
  • Author(s): Ogasawara M., Imanishi T., Moriwaki K., Gaudieri S., Tsuda H., Hashimoto H., Shiroishi T., Gojobori T., Koide T.
  • Journal Title: Gene 349 Pages: 107-119
  • Peer Reviewed
• [Presentation] マウス亜種間コンソミック系統を用いた多因子形質の遺伝解剖 (2010)
  • Author(s): 城石俊彦
  • Organizer: 第24回日本糖尿病・肥満動物学会年
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-23
• [Presentation] 遺伝的不適合マウスではレトロトランスポゾンIAPの発現が上昇している (2009)
  • Author(s): 梅森十三, 湯浅茂樹, 宇野毅明, 小出剛
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-20091212
• [Presentation] Different patterns of ultrasonic vocalizations of wild-derived mouse strains from laboratory strains (2009)
  • Author(s): 杉本大樹, 菊水健史, 城石俊彦, 小出剛
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-20091212
• [Presentation] 野生マウスに特徴的な不安様行動の遺伝学的解析 (2009)
  • Author(s): 田邉彰, 石井亜矢子, 城石俊彦, 高橋阿貴, 小出剛
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜.
  • Year and Date: 20091209-20091212
• [Presentation] Genetic dissection of age-associated phenotypes using intersubspecific consomic strains (2009)
  • Author(s): Takada T., Mita A., Ebata T., Shin-I T., Toyoda A., Fujiyama A., Kohara Y., Obata Y., Moriwaki K., Yonekawa H., Shiroishi T.
  • Organizer: 23th International Mammalian Genome Conference
  • Place of Presentation: Jolla, USA.
  • Year and Date: 20091101-20091104
• [Presentation] Decreased expression of myelination associated genes in genetic incompatibility mice, Genic mice. (2009)
  • Author(s): Umemori, J., Uno, T., Yuasa, S., Koide, T.
  • Organizer: 23rd International Mammalian Genome Conference, La Jolla Torrey Pines
  • Place of Presentation: California
  • Year and Date: 20091101-20091104
• [Presentation] マウス亜種間コンソミック系統を用いたエネルギー代謝多様性の遺伝解析 (2009)
  • Author(s): 高田豊行, 三田晃彦, 森脇和郎, 米川博通, 城石俊彦
  • Organizer: 日本遺伝学会
  • Place of Presentation: 松本
  • Year and Date: 20090916-20090918
• [Presentation] B6-MSMコンソミックマウス系統を用いた自発活動性の遺伝学的解析 (2009)
  • Author(s): 石井亜矢子, 西明紀, 城石俊彦, 小出剛
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090916-20090918
• [Presentation] 遺伝的不適合マウスは脊髄オリゴデンドロサイトの成熟が異常である (2009)
  • Author(s): 梅森十三, 宇野毅明, 湯浅茂樹, 小出剛
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090916-20090918
• [Presentation] マウス攻撃行動における遺伝的基盤の解析 (2009)
  • Author(s): 杉本大樹, 高橋阿貴, 城石俊彦, 小出剛
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090916-20090918
• [Presentation] コンソミックマウス系統を用いた不安様行動の高解像度マッピング (2009)
  • Author(s): 田邉彰, 石井亜矢子, 城石俊彦, 高橋阿貴, 小出剛
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090916-20090918
• [Presentation] Making a database to link mouse genome diversity and phenotype Symposium in International Phenome Integration Meeting (2009)
  • Author(s): Takada, T.
  • Organizer: RIKEN/InterPhenome/CASIMIR
  • Place of Presentation: Shiga, Japan
  • Year and Date: 20090712-20090713
• [Presentation] Molecular and genetic analysis for aggressive behavior using B6-MSM consomic mouse strains. (2009)
  • Author(s): Sugimoto, H., Takahashi, A., Shiroishi, T., Koide, T.
  • Organizer: 11th Annual Meeting of the International Behavioural and Neurogenetics Society
  • Place of Presentation: Dresden
  • Year and Date: 20090604-20090608
• [Presentation] マウス亜種間コンソミック系統群を用いた多因子肥満症の遺伝解析 (2009)
  • Author(s): 高田豊行, 三田晃彦, 森脇和郎, 米川博通, 城石俊彦
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮
  • Year and Date: 20090514-20090516
• [Presentation] 遺伝的不適合による神経発達異常 (2009)
  • Author(s): 梅森十三, 近藤亮太, 宇野毅明, 湯浅茂樹, 小出剛
  • Organizer: 第56回日本実験動物学会
  • Place of Presentation: 大宮
  • Year and Date: 20090514-20090516
• [Presentation] NIG Mouse Functional Genomics Database (2009)
  • Author(s): 高田豊行, 江端俊伸, 小原雄治, 城石俊彦
  • Organizer: 文科省統合データベースプロジェクト「データベースが拓くこれからのライフサイエンス」
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] 日本産野生マウス由来系統の遺伝的多様性を基盤とした機能ゲノム学 (2009)
  • Author(s): 高田豊行
  • Organizer: かずさDNA研究所ワークショップ「遺伝的多様性に基づく有用遺伝子座の探索」
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-25
• [Presentation] Two wave intersubspecific introgression built up genome framework of the classical laboratory mouse strains. (2008)
  • Author(s): Takada T., Ebata T., Shin-I., Narita T., Abe K., Sakaki Y., Toyoda A., Obata Y., Moriwaki K., Kohara Y., Shiroishi T.
  • Organizer: 22th International Mammalian Genome Conference
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 20081102-20081105
• [Presentation] Complex genetic architecture of social interaction and aggressive behavior clarified using consomic strains derived from MSM and C57BL/6. (2008)
  • Author(s): Takahashi, A., Sugimoto, H., Kimura, S., Tomihara, K., Tsuchiya, T., Kakihara, S., Tanemura, M., Shiroishi, T., Koide, T.
  • Organizer: 22nd International Mammalian Genome Conference
  • Place of Presentation: Prague
  • Year and Date: 20081102-20081105
• [Presentation] Mouse inter-subspecific consomic strains uncovers additive and non-additive genetic effects on complex traits. (2008)
  • Author(s): Takada, T., Mita, A., Maeno, A., Moriwaki, K., Yonekawa, H., Shiroishi, T.
  • Organizer: 22th International Mammalian Genome Conference
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 20081102-20081105
• [Presentation] Mouse inter-subspecific consomic strains for the study of energy metabolism-related traits (2008)
  • Author(s): Takada, T., Mita, A., Moriwaki, K., Yonekawa, H., Shiroishi, T.
  • Organizer: CBI Annual Meeting 2008 International Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20081022-20081024
• [Presentation] B6-MSMコンソミックマウス系統を用いた跳躍行動に関わる遺伝的メカニズムの解析 (2008)
  • Author(s): 石井亜矢子, 高橋阿貴, 西明紀, 城石俊彦, 小出剛
  • Organizer: 第68回日本動物心理学会大会
  • Place of Presentation: 水戸
  • Year and Date: 20080913-20080914
• [Presentation] マウス亜種間コンソミック系統群を用いた肥満関連表現型の遺伝解析 (2008)
  • Author(s): 高田豊行, 三田晃彦, 森脇和郎, 米川博通, 城石俊彦
  • Organizer: 日本遺伝学会
  • Place of Presentation: 名古屋
  • Year and Date: 20080903-20080905
• [Presentation] 遺伝的不適合による神経発達異常 (2008)
  • Author(s): 梅森十三, 近藤亮太, 宇野毅明, 湯浅茂樹, 小出剛
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 20080709-20080711
• [Presentation] B6-MSMコンソミックマウス系統を用いた跳躍行動の遺伝学的行動学的解析 (2008)
  • Author(s): 石井亜矢子, 高橋阿貴, 西明紀, 城石俊彦, 小出剛
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 20080709-20080711
• [Presentation] マウス亜種間コンソミック系統群を用いたエネルギー代謝関連形質の遺伝解析 (2008)
  • Author(s): 高田豊行, 三田晃彦, 森脇和郎, 米川博通, 城石俊彦
  • Organizer: 第55回日本実験動物学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20080515-20080517
• [Presentation] Fine genetic mapping of emotionality-related traits on distal end of mouse chromosome 17. (2008)
  • Author(s): Takahashi, A., Shiroishi, T., Koide, T.
  • Organizer: 10th Annual Meeting of the International Behavioural and Neural Genetics Society
  • Place of Presentation: Portland
  • Year and Date: 20080505-20080509
• [Presentation] Genetic analysis of inter-male aggression using consomic mouse strains established from C57BL/6J and MSM (2008)
  • Author(s): Takahashi, A., Tomihara, K., Shiroishi, T., Koide, T.
  • Organizer: 10th Annual Meeting of the International Behavioural and Neural Genetics Society
  • Place of Presentation: Portland
  • Year and Date: 20080505-20080509
• [Presentation] マウス亜種間コンソミック系統によるゲノム機能解析 (2008)
  • Author(s): 城石俊彦
  • Organizer: 第44回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 出雲
  • Year and Date: 2008-12-22
• [Presentation] 糖尿病研究におけるforward geneticsアプローチ (2008)
  • Author(s): 城石俊彦
  • Organizer: 第1回疾患モデルシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-03
• [Presentation] ゲノム解読から見えてきた汎用実験用マウス系統の起源 (2008)
  • Author(s): 城石俊彦
  • Organizer: 第11回遺伝談話会「日本の野生生物と遺伝学」
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-09
• [Presentation] マウスゲノム多型に基づく多因子表現型の解析 (2008)
  • Author(s): 城石俊彦
  • Organizer: 第4回生命資源研究・支援センター国際シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2008-02-15
• [Presentation] ゲノム多型と表現型をマウスでつなぐ (2008)
  • Author(s): 城石俊彦
  • Organizer: 文部科学省科研費特定領域研究「ゲノム」4領域成果公開シンポジウム
  • Place of Presentation: 品川
  • Year and Date: 2008-01-28
• [Presentation] Whole genome shotgun sequencing of M.M. Molossinus-derived MSM/Ms and detection of vast amount of SNPs against C57BL/6. (2007)
  • Author(s): akada, T., Ebata, T., Narita, T., Shin-I, T., Abe, K., Sakaki, Y., Toyoda, A., Sagai T., Mita, A., Moriwaki, K., Kohara, Y., Shiroishi, T.
  • Organizer: 21th International Mammalian Genome Conference
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 20071028-20071101
• [Presentation] Functional genomics of genomics of complex trains with inter-subspecific consomic strains. (2007)
  • Author(s): Shiroishi, T.
  • Organizer: 21th International Mammalian Genome Conference
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20071028-20071101
• [Presentation] Aberrant neurological development caused by genetic incompatibility between two wild-derived mouse strains. (2007)
  • Author(s): Umemori, J., Kondou, R., Uno, T., Yuasa, S., Koide, T.:
  • Organizer: 21st International Mammalian Genome Conference
  • Place of Presentation: Kyoto
  • Year and Date: 20071000
• [Presentation] Systematic analysis of behavioral traits using consomic mouse strains established from C57BL/6J and wild-derived MSM. (2007)
  • Author(s): Takahashi, A., Ishii, A., Nishi, A., Shiroishi, T., Koide, T.
  • Organizer: 21st International Mammalian Genome Conference
  • Place of Presentation: Kyoto
  • Year and Date: 20071000
• [Presentation] マウス亜種間コンソミック系統群を用いたエネルギー代謝関連形質の遺伝解析 (2007)
  • Author(s): 高田豊行, 三田晃彦, 前野哲輝, 森脇和郎, 米川博通, 城石俊彦
  • Organizer: 日本遺伝学会
  • Place of Presentation: 岡山
  • Year and Date: 20070919-20070921
• [Presentation] C57BL/6JとMSM系統から作出されたコンソミックマウス系統を用いた攻撃行動の遺伝学的解析 (2007)
  • Author(s): 高橋阿貴、富原一哉、城石俊彦、小出剛
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 20070910-20070912
• [Presentation] QTL analysis of differences of activities in home-cage and open-field between KJR and B6 mouse strains. (2007)
  • Author(s): Umemori, J., Nishi, A., Takahashi, A., Kawasaki, Y., Lionikas, A., Blizard, DA., Koide, T.
  • Organizer: The Complex Trait Consortium 6th Annual Meeting
  • Place of Presentation: Braunschweig, Germany.
  • Year and Date: 20070526-20070529
• [Presentation] Forward genetics approach toward complex traits using consomic mouse strains established from C57BL/6J and wild-derived MSM. (2007)
  • Author(s): Takahashi, A., Ishii, A., Nishi, A., Shiroishi, T. Koide, T.
  • Organizer: The International Behavioural and Neural Genetics Society Annual Meeting
  • Place of Presentation: Doorwerth, The Netherlands
  • Year and Date: 20070521-20070525
• [Presentation] Systematic analysis of behavioral traits in a series of consomic mouse strains established from C57BL/6J and wild-derived MSM. (2007)
  • Author(s): Koide, T., Ishii, A., Nishi, A., Shiroishi, T., Takahashi, A.
  • Organizer: The International Behavioural and Neural Genetics Society Annual Meeting
  • Place of Presentation: Doorwerth, The Netherlands.
  • Year and Date: 20070521-20070525
• [Presentation] Functional Genomics of Complex Traits Based on Mouse Inter-Subspecific Differences. (2007)
  • Author(s): Shiroishi, T.
  • Organizer: 第23回国際生物学賞シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2007-11-21
• [Presentation] 17番染色体コンソミックマウス系統を用いた情動性の遺伝学的解析 (2007)
  • Author(s): 高橋阿貴、石井亜矢子、城石俊彦、小出剛
  • Organizer: 第67回日本動物心理学会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-07
• [Presentation] ゲノム解読から見えてきた実験用マウスの起源:新たな実験用マウス系統の開発と利用. (2007)
  • Author(s): 城石俊彦
  • Organizer: 第6回四国免疫フォーラム.
  • Place of Presentation: 松山
  • Year and Date: 2007-07-14
• [Presentation] マウス亜種間ゲノム多型と表現型多様性の統合によるゲノム機能解析. (2006)
  • Author(s): 城石俊彦
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 20061206-20061208
• [Presentation] マウス亜種間コンソミック系統を基盤としたゲノム機能解析:エネルギー代謝関連表現型と遺伝子発現プロファイルデータの統合 (2006)
  • Author(s): 高田豊行, 三田晃彦, 前野哲輝, 森脇和郎, 米川博通, 城石俊彦
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 20061206-20061208
• [Presentation] マウス系統間交配で生じる遺伝的不適合の分子遺伝学的解析 (2006)
  • Author(s): 近藤亮太、梅森十三、小出剛
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 20061206-20061208
• [Presentation] 遺伝的不適合により生じる神経発達異常 (2006)
  • Author(s): 梅森十三、湯浅茂樹、小出剛
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 20061206-20061208
• [Presentation] 多因子表現型の遺伝解析系としてのマウス亜種間コンソミック系統の樹立と応用 (2006)
  • Author(s): 高田豊行, 三田晃彦, 前野哲輝, 岡彩子, 田村勝, 坂井隆浩, 設楽浩志, 吉川欣亮, 森脇和郎, 米川博通, 城石俊彦
  • Organizer: 日本遺伝学会
  • Place of Presentation: つくば
  • Year and Date: 20060925-20060927
• [Presentation] 行動多様性に関わる遺伝子の探索:B6-MSMコンソミック系統を用いて (2006)
  • Author(s): 高橋阿貴、西明紀、城石俊彦、小出剛
  • Organizer: 第29回日本神経科学大会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 20060719-20060721
• [Presentation] 精神疾患に関連する行動の遺伝学:コンソミックマウスの解析 (2006)
  • Author(s): 小出剛
  • Organizer: 第14回日本精神・行動遺伝医学会シンポジウム
  • Place of Presentation: 筑波
  • Year and Date: 2006-11-18
• [Book] Acute Pain: Causes, Effects and Treatment(Sam D'Alonso and Katherine L. Grasso ed, Advantage of using wild-derived mouse strains for a variety of pain-related studies: Genetic diversity and new genetic tools.) (2009)
  • Author(s): Koide T, Catanesi CI, Nishi A, Shiroishi T, Kasai S, Ikeda K, Takahashi A.
  • Publisher: Nova Science Publishers
• [Book] 細胞工学別冊(監修, 藤山秋佐夫, マウスの比較ゲノム, 日本産マウス系統のゲノム解読とコンソミック系統の樹立, 比較ゲノム学から読み解く生命システム) (2007)
  • Author(s): 高田豊行、城石俊彦
  • Total Pages: 97-104
  • Publisher: 秀潤社
• [Remarks] データベース名:NIG Mouse Phenotype Database ( NIGマウス表現型DB )
  • URL: http://molossinus.lab.nig.ac.jp/phenotype/index.html
• [Remarks] データベース名: NIG Mouse Genome Database(NIGマウスゲノムDB)
  • URL: http://molossinus.lab.nig.ac.jp/msmdb/