2009 Fiscal Year Final Research Report
Identification and clinical application of susceptibility genes for diabetes mellitus.
| Project/Area Number |
17019047
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kobe University |
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Principal Investigator |
KASUGA Masato Kobe University, 研究所, 所長 (50161047)
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| Co-Investigator(Kenkyū-buntansha) |
KADOWAKI Takashi 東京大学, 大学院・医学系研究科, 教授 (30185889)
YASUDA Kazuki 国立国際医療センター, 研究所, 部長 (80311611)
OOSAWA Haruhiko 愛媛大学, 医学部, 教授 (90294800)
NANJO Kishio 和歌山県立医科大学, 医学部, 教授 (40164511)
KIDO Yoshiaki 神戸大学, 保健学研究科, 准教授 (10335440)
MAKINO Eiichi 愛媛大学, 医学部, 教授 (50009578)
MIYAKE Kazuaki 神戸大学, 医学部付属病院, 医員 (40452495)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 糖尿病 / 遺伝子 / KCNQ1 / GWAS / 候補遺伝子 / 予測モデル |
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| Research Abstract |
By a genome-wide association study (GWAS) using 100,000 SNPs, we identified KCNQ1 as a novel susceptibility gene for type 2 diabetes mellitus, and performed functional analysis. This turned out to be one of the most important genetic factors in multiple ethnic groups. We also examined other genetic factors for diabetes and found that risk allele frequencies of the SNPs are variable among populations. Furthermore, we reported that the prediction power of all the susceptibility SNPs combined is not sufficient, indicating the existence of unknown genetic factors. We also reported novel diabetes-related genes by candidate gene and candidate region approaches.
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[Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.2010
Author(s)
Okamoto, K., Yasuda, K. (16番目), Osawa, H. (17), Nanjo, K. (18), Kadowaki, T. (19), Kasuga, M. (20), ほか19名
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Journal Title
Am J Hum Genet 86(1)
Pages: 54-64
Peer Reviewed
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[Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association.2009
Author(s)
Miyake, K., Yasuda, K. (4番目), Osawa, H. (6番目), Makino, H. (32番目), Nanjo, K. (33), Kadowaki, T. (34), Kasuga, M. (35人中35番目), ほか28名
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Journal Title
J Hum Genet 54(4)
Pages: 236-41
Peer Reviewed
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[Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.2008
Author(s)
Yasuda, K., Miyake, K., Osawa, H. (5番目), Makino, H. (44番目), Nanjo, K. (45), Kadowaki, T. (46), Kasuga, M. (47人中47番目), ほか40名
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Journal Title
Nature Genetics 40(9)
Pages: 1092-1097
Peer Reviewed
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[Journal Article] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4, 087 Japanese subjects.2008
Author(s)
Miyake, K., Yasuda, K. (4番目), Osawa, H. (5番目), Makino, H. (20番目), Nanjo, K. (21), Kadowaki, T. (22), Kasuga, M. (23人中23番目), ほか16名
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Journal Title
J Hum Genet 53(2)
Pages: 174-180
Peer Reviewed
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[Journal Article] Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes.2007
Author(s)
Ochi, M., Osawa, H., Kadowaki, T. (13番目), Kasuga, M. (15番目), Makino, H. (16人中16番目), ほか11名
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Journal Title
Diabetes 56
Pages: 2834-8
Peer Reviewed
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