2010 Fiscal Year Final Research Report
Role of the cortico-basal ganglia system in action and cognition
| Project/Area Number |
17022032
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KIMURA Minoru Kyoto Prefectural University of Medicine, 脳科学研究所, 教授 (40118451)
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| Co-Investigator(Kenkyū-buntansha) |
FUSHIKI Shinji 京都府立医科大学, 医学研究科, 教授 (80150572)
NAKAGAWA Masanori 京都府立医科大学, 医学研究科, 教授 (50198040)
UEDA Yasumasa 京都府立医科大学, 医学研究科, 講師 (60332954)
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| Project Period (FY) |
2005 – 2010
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| Keywords | 大脳基底核 / 線条体 / ドーパミン系 / 視床CM核 / 報酬価値 / 意志決定 / 行動選択 / 長期的報酬予測 |
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| Research Abstract |
We showed that neuronal activity in the striatum represents reward value of action options and actions associated with reward values. In the intralaminar nuclei of thalamus, CM nucleus, we demonstrated specific neuronal activation at the request of unanticipated action while the subjects were anticipated higher-value action. The results suggested involvement of the CM nucleus in second-best solution for long-term goal. Furthermore, we found that midbrain dopamine neurons encode long-term reward value and its expectation error, which may play a critical role in achieving long-term goal through multi-step actions.
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