2009 Fiscal Year Final Research Report
Study on molecular mechanisms for regulating proliferation and differentiation of embryonic neural stem cells
| Project/Area Number |
17024001
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
OSUMI Noriko Tohoku University, 大学院・医学系研究科, 教授 (00220343)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masanori 東北大学, 大学院・医学系研究科, 助教 (20361074)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 神経発生 / 細胞増殖 / 細胞分化 / 転写因子 / Pax6 / タイムラプス解析 / マイクロアレイ解析 / 神経幹細胞 |
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| Research Abstract |
We investigated molecular mechanisms of proliferation and differentiation of neural stem cells especially focusing on Pax6 transcription factor, a key regulator of brain development, and its downstream molecules. We also revealed that subcellular localization of Cyclin D2, a cell cycle regulator, is crucial to keep the neural stem cells proliferative.
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[Journal Article] Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain.2010
Author(s)
Numayama-Tsuruta, K., Arai, Y., Takahashi, M., Sasaki-Hoshino, M., Funatsu, N., Nakamura, S., Osumi, N.
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Journal Title
Peer Reviewed
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[Journal Article] Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells.2007
Author(s)
Tamai, H., Shinohara, H., Miyata, T., Saito, K., Nishizawa, Y., Nomura, T., Osumi, N.
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Journal Title
Genes Cells. 12(9)
Pages: 983-996
Peer Reviewed
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[Journal Article] Role of Fabp7, a downstream gene of Pax6, in the meintenance of neuroepithelial cells during early embryonic development of the rat cortex.2005
Author(s)
Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., Osumi, N.
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Journal Title
J Neurosci. 25(42)
Pages: 9752-9761
Peer Reviewed
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[Presentation] Centrosomal protein ninein may control interkinetic nuclear migration in neuroepithelial cells.2010
Author(s)
Shinohara, H., Miyata, T., Takahashi, M., Osumi, N.
Organizer
Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
Place of Presentation
San Diego, CA, USA
Year and Date
2010-11-14
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[Presentation] Spatiotemporal post-transcriptional regulation of Cyclin D2 mRNA induces asymmetrical cell fates in neuroepithelial cells and self-organization of corticogenesis.2010
Author(s)
Tsunekawa, Y., Joanne, Brito., Takahashi, M., Seng-Song, Tan., Osumi, N.
Organizer
Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
Place of Presentation
San Diego, CA, USA
Year and Date
2010-11-14
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[Presentation] Analysis of Dmrt4 as a downstream gene of Pax6 in early development of the telencephalon.2010
Author(s)
Kikkawa, T., Fukuzaki, U., Numayama-Tsuruta, K., Takahashi, M., Osumi, N.
Organizer
Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
Place of Presentation
San Diego, CA, USA
Year and Date
2010-11-14
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[Remarks] ホームページ等
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