2009 Fiscal Year Final Research Report
Patterning dendritic arbors : molecular mechanisms controlling branching and arbor size
| Project/Area Number |
17024025
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
UEMURA Tadashi Kyoto University, 大学院・生命科学研究科, 教授 (80213396)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Keywords | 樹状突起 / 神経細胞 / ショウジョウバエ / 細胞骨格 / Rhoファミリー / 分子遺伝学 |
|---|
| Research Abstract |
Dendrites allow neurons to integrate information from sensory or synaptic inputs. The spatial disposition and local density of branches within the arbor limit the number and type of inputs. We have shown that a group of transcriptional regulators are expressed selectively in subclasses and that they exert their cell-autonomous functions to control formation of the class-specific arbors. Our genetical as well as in vivo cell-biological approaches have revealed an important link between microtubule motors and organelles, such as endosomes, in controlling branch density and spatial disposition of branches within dendritic arbors. Finally we have found that a novel family of mitochondrial proteins is important for preventing breakage of dendritic branches.
|
Research Products
(17 results)
-
-
-
[Journal Article] Mitochondrial Protein Preli-like Is Required for Development of Dendritic Arbors and Prevents Their Regression in the Drosophila Sensory Nervous System.2009
Author(s)
Tsubouchi, A., Tsuyama, T., Fujioka, M., Kohda, H., Okamoto-Furuta, K., Aigaki, T., Uemura, T.
-
Journal Title
Development 136
Pages: 3757-3766
Peer Reviewed
-
[Journal Article] Multidendritic sensory neurons in the adult Drosophila abdomen : origins, dendritic morphology, and segment- and age-dependent programmed cell death.2009
Author(s)
Shimono, K., Fujimoto, A., Tsuyama, T., Yamamoto-Kochi, M., Sato, M., Hattori, Y., Sugimura, K., Usui, T., Kimura, K., Uemura, T.
-
Journal Title
Neural Development 4
Pages: 37
Peer Reviewed
-
[Journal Article] Spatial Control of Branching within Dendritic Arbors by Dynein-Dependent Transport of Rab5-Endosomes.2008
Author(s)
Satoh, D., Sato, D., Tsuyama, T., Saito, M., Ohkura, H., M.Rolls, M., Ishikawa, F., Uemura, T.
-
Journal Title
Nature Cell Biology 10
Pages: 1164-1171
Peer Reviewed
-
-
[Journal Article] Opposing roles in neurite growth control by two 7-pass transmembrane cadherins.2007
Author(s)
Shima, Y., Kawaguchi, S., Kosaka, K., Nakayama, M., Hoshino, M., Nabeshima, Y., Hirano, T., Uemura, T.
-
Journal Title
Nature Neuroscience 10
Pages: 963-969
Peer Reviewed
-
-
[Journal Article] Polarity and intracellular compartmentalization of Drosophila neurons.2007
Author(s)
M Rolls, M., Satoh, D., J Clyne, P., L Henner, L., Uemura, T., Q Doe, Q.
-
Journal Title
Neural Development 2
Pages: 7-21
Peer Reviewed
-
-
-
-
-
-
-
-
