2009 Fiscal Year Final Research Report
Analysis of the ubiquitin ligase complexes that regulates the transcription of nuclear receptors.
| Project/Area Number |
17054005
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tsukuba |
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Principal Investigator |
YANAGISAWA Junn University of Tsukuba, 大学院・生命環境科学研究科, 教授 (50301114)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ゲノム / 蛋白質 / 発現制御 / プロテオーム |
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| Research Abstract |
We notice the nuclear receptors as factors that connect DECODE networks with DECODE complex, and tried to analyze the transcriptional regulations.
We have found that CHIP, a U-box-type ubiquitin ligase, is implicated in degradation of estrogen receptor (ER), and that CHIP has tumor suppressive role. Moreover, we found that ER promotes Smad degradation by recruiting unknown ubiqutin ligase(s) to Smad complex. We also identified Nucleomethylin (NML),a novel nucleolar protein, and eNoSC, a novel protein complex that connect energy signal with DECODE network..
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[Journal Article] Estrogen inhibits TGF-{beta} signaling by promoting Smad2/3 degradation2010
Author(s)
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J
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Journal Title
The Journal of biological chemistry (In press)
Peer Reviewed
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[Journal Article] The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A2009
Author(s)
akemoto A, Maeshima K, Ikehara T, Yamaguchi K, Murayama A, Imamura S, Imamoto N, Yokoyama S, Hirano T, Watanabe Y, Hanaoka F, Yanagisawa J, Kimura K
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Journal Title
Nature Structural & Molecular Biology Vol.16,No.12
Pages: 1302-1308
Peer Reviewed
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[Journal Article] The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways2009
Author(s)
Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-ma K, Ito I, Yamaguchi Y, Ohie S, Kobayashi Y, Seino Y, Kawano M, Kawabe YI, Takei H, Hayashi S, Kurosumi M, Murayama A, Kimura K, Yanagisawa J
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Journal Title
Nature Cell Biol Vol.11,No3
Pages: 312-319
Peer Reviewed
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[Journal Article] Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs2008
Author(s)
Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y
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Journal Title
Cell Stem Cell Vol.3,No5
Pages: 555-567
Peer Reviewed
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[Journal Article] Epigenetic control of rDNA loci in response to intracellular energy status2008
Author(s)
Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Simizu T, Yanagisawa J
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Journal Title
Peer Reviewed
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[Journal Article] PPARy ligands suppress the feedback loop between E2F2 and cyclin-El2008
Author(s)
Komatsu Y, Ito I, Wayama M, Fujimura A, Akaogi K, Machida H, Nakajima Y, Kuroda T, Ohmori K, Murayama A, Kimura K, Yanagisawa J
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Journal Title
Biochem Biophys Res Commun Vol.370,No.1
Pages: 145-148
Peer Reviewed
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[Journal Article] Turning Off Estrogen Receptor β-Mediated Transcription Requires Estrogen-Dependent Receptor Proteolysis2006
Author(s)
Tateishi Y, Sonoo R, Sekiya Y, Sunahara N, Kawano M, Wayama M, Hirota R, Kawabe Y, Murayama A, Kato S, Kimura K, Yanagisawa J
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Journal Title
MoL Cell. Biol 26
Pages: 7966-7976
Peer Reviewed
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[Journal Article] A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory2006
Author(s)
Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, Tateishi Y, Wang Y, Ushijima T, Shibuya K, Kawabe Y, Yanagisawa J
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Journal Title
EMBO J 25
Pages: 1081-1092
Peer Reviewed
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[Journal Article] Repressive domain of unliganded human estrogen receptor alpha associates with Hsc702005
Author(s)
Ogawa S, Oishi H, Mezaki Y, Kouzu-Fujita M, Matsuyama R, Nakagomi M, Mori E, Murayama E, Nagasawa H, Kitagawa H, Yanagisawa J, Yano T, Kato S
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Journal Title
Genes Cells 10
Pages: 1095-1102
Peer Reviewed
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[Presentation]2009
Author(s)
柳澤純
Organizer
第9回TCカンファレンス(興和製薬株式会社)
Place of Presentation
興和製薬株式会社東京
Year and Date
2009-06-06
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[Remarks] 受賞等
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[Remarks] 柳澤純.BEST FACULTY MEMBER 2009「研究」領域 表彰 筑波大学,2009.3.9.
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[Remarks] 柳澤明子,柳澤純若手科学者賞,科学技術分野文部科学大臣表彰,2009.4.14.
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[Remarks] 柳澤純.第5回日本学術振興会賞,独立行政法人日本学術振興会,2009.3.9.
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[Remarks] 柳澤純.筑波大学賞,筑波大学,2009.2.19.
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[Remarks] 仲島由佳,柳澤純.第9回関東ホルモンと癌研究会,研究奨励賞,東京,2009.1.24.
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[Remarks] 神代理史,川崎祥平,柳澤純.09' 遺伝情報DECODE冬のワークショップ,DECODE賞,湯沢,2009.1.21.
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[Remarks] 大森一二,柳澤純.Keystone Symposia Scholarship, Colorado, 2008.3.30-2008.4.4.
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[Remarks] 小松蓉子,柳澤純.08' 遺伝情報DECODE冬のワークショップ,DECODE賞,湯沢,2008.1.23.
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[Remarks] 伊藤一明,柳澤純.第8回関東ホルモンと癌研究会,研究奨励賞,東京,2008.1.19.
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[Remarks] 新聞報道
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[Remarks] 1) 乳がんの転移抑制たんぱく質発見に関する新聞記事
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[Remarks] 1.1 読売新聞(夕刊)2009年2月9日(月)
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[Remarks] 1.2 日本経済新聞、2009年2月10日(火)
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[Remarks] 1.3 日刊工業新聞2009年2月10日(火)
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[Remarks] 1.4 毎日新聞2009年2月10日(火)
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[Remarks] 1.5 茨城新聞2009年2月10日(火)
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[Remarks] 1.6 Thomson Reuters, Mon Feb 9, 2009
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[Remarks] 1.7 "Research Highlights", Nature Reviews Cancer, vol.9, April 2009.
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[Remarks] 2) 細胞内のエネルギー消費・生産を制御するたんぱく質に関する新聞記事
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[Remarks] 2.1 日経産業新聞2008年5月19日(月)
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[Remarks] 2.2 科学新聞2008年5月30日(金)
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[Remarks] 2.3 "Research Highlights", Nature, vol. 453, 29 May 2008, p. 566.
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[Remarks] 2.4 "Minireview", Cell, 133, May 16 2008, p. 577.
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[Remarks] 2.5 "Research Roundup", JCB, vol. 181. num. 5. 2008, p. 714.
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[Remarks] 2.6 "Naturenews", 30 May 2008. (インターネット版)
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[Remarks] 3) 第5回日本学術振興会賞受賞に関する新聞記事
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[Remarks] 3.1 科学新聞2009年2月13日(金)
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