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2009 Fiscal Year Final Research Report

Comparative Analysis of the DECODE Systems in Hematopoiesis and Oxidative Stress Response

Research Project

  • PDF
Project/Area Number 17054028
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

IGARASHI Kazuhiko  Tohoku University, 大学院・医学系研究科, 教授 (00250738)

Co-Investigator(Kenkyū-buntansha) MUTO Akihiko  東北大学, 大学院・医学系研究科, 講師 (80343292)
Project Period (FY) 2005 – 2009
KeywordsBach1 / Bach2 / 転写因子 / クロマチン / 発現制御
Research Abstract

DECODE complexes of Bach1, Bach2, and MafK were purified and characterized by using mass spectrometry analysis. Bach1 was found to interact with the tumor suppressor p53 and to inhibit cellular senescence induced by oxidative stress. Bach1 recruits histone deacetylase 1 to some of the p53 target genes and promotes histone deacetylation. In addition, a DECODE gene circuit for the class switch recombination of antibody genes has been identified.

  • Research Products

    (12 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results)

  • [Journal Article] Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes.2010

    • Author(s)
      Okada, S., Muto, A., Ogawa, E., Nakanome, A., Katoh, Y., Ikawa, S., Aiba, S., Igarashi, K., Okuyama, R
    • Journal Title

      J. Biol. Chem (in press)

    • Peer Reviewed
  • [Journal Article] Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.2009

    • Author(s)
      MacLeod, A. K, McMahon, M., Plummer, S.M., Higgins, L.G., Penning, T.M., Igarashi, K., Hayes JD
    • Journal Title

      Carcinogenesis 30

      Pages: 1571-1580

    • Peer Reviewed
  • [Journal Article] Crystal structure of the Bach1 BTB domain and its regulation of homodimerization.2009

    • Author(s)
      Ito, N., Watanabe-Matsui, M., Igarashi, K., Murayama, K
    • Journal Title

      Genes Cells 14

      Pages: 1365-2443

    • Peer Reviewed
  • [Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.2008

    • Author(s)
      Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., Yoshida, M., Noda, T., Igarashi, K
    • Journal Title

      Nature Struct. Mol. Biol 15

      Pages: 1246-1254

    • Peer Reviewed
  • [Journal Article] Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6.2008

    • Author(s)
      Ochiai, K., Muto, A., Tanaka, H., Takahashi, S., Igarashi, K
    • Journal Title

      Int. Immunol 20

      Pages: 453-460

    • Peer Reviewed
  • [Journal Article] Heme induces ubiquitination and degradation of the transcription factor Bach1.2007

    • Author(s)
      Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwai, K., Igarashi, K
    • Journal Title

      Mol. Cell. Biol 27

      Pages: 6962-6971

    • Peer Reviewed
  • [Journal Article] Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells.2006

    • Author(s)
      Ochiai, K., Katoh, Y., Ikura, T., Hoshikawa, Y., Noda, T., Karasuyama, H., Tashiro, S., Muto, A., Igarashi, K
    • Journal Title

      J. Biol. Chem 281

      Pages: 38226-38234

    • Peer Reviewed
  • [Journal Article] Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury.2005

    • Author(s)
      Omura, S., Suzuki, H., Toyofuku, M., Ozono, R., Kohno, N., Igarashi, K
    • Journal Title

      Genes Cells 10

      Pages: 277-285

    • Peer Reviewed
  • [Presentation] 核内メチル化反応を支えるタンパク質ネットワーク2010

    • Author(s)
      五十嵐和彦
    • Organizer
      日本薬学会シンポジウム
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-29
  • [Presentation] Cross-talk between Bach1, NF-kB, and IL-6 in epithelial-mesenchymal transition2009

    • Author(s)
      Brydun, A., Nakanome A., Matsumoto, M., Ota, K., Dohi, Y., Igarashi, K
    • Organizer
      American Association for Cancer Reserch International Conference on Frontiers in Basic Cancer Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      20091008-20091011
  • [Presentation] Regulation of cell proliferation by the heme-Bach1 pathway2006

    • Author(s)
      Kazuhiko Igarashi
    • Organizer
      Gordon Research Conference on Tetrapyrroles, Chemistry and Biology of
    • Place of Presentation
      Newport, RI, USA
    • Year and Date
      20060723-20060728
  • [Presentation] Heme-mediated gene regulation in mammalian cells2005

    • Author(s)
      K. Igarashi, Y. Zenke, Y. Dohi
    • Organizer
      Cold Spring Harbor Laboratory Meeting "Mechanisms of eukaryotic transcription"
    • Place of Presentation
      マイアミ. USA
    • Year and Date
      20050831-20050904

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Published: 2011-06-18   Modified: 2016-04-21  

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