2009 Fiscal Year Final Research Report
Comparative Analysis of the DECODE Systems in Hematopoiesis and Oxidative Stress Response
Project/Area Number |
17054028
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Tohoku University |
Principal Investigator |
IGARASHI Kazuhiko Tohoku University, 大学院・医学系研究科, 教授 (00250738)
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Co-Investigator(Kenkyū-buntansha) |
MUTO Akihiko 東北大学, 大学院・医学系研究科, 講師 (80343292)
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Project Period (FY) |
2005 – 2009
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Keywords | Bach1 / Bach2 / 転写因子 / クロマチン / 発現制御 |
Research Abstract |
DECODE complexes of Bach1, Bach2, and MafK were purified and characterized by using mass spectrometry analysis. Bach1 was found to interact with the tumor suppressor p53 and to inhibit cellular senescence induced by oxidative stress. Bach1 recruits histone deacetylase 1 to some of the p53 target genes and promotes histone deacetylation. In addition, a DECODE gene circuit for the class switch recombination of antibody genes has been identified.
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[Journal Article] Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes.2010
Author(s)
Okada, S., Muto, A., Ogawa, E., Nakanome, A., Katoh, Y., Ikawa, S., Aiba, S., Igarashi, K., Okuyama, R
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Journal Title
Peer Reviewed
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[Journal Article] Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.2009
Author(s)
MacLeod, A. K, McMahon, M., Plummer, S.M., Higgins, L.G., Penning, T.M., Igarashi, K., Hayes JD
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Journal Title
Carcinogenesis 30
Pages: 1571-1580
Peer Reviewed
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[Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.2008
Author(s)
Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., Yoshida, M., Noda, T., Igarashi, K
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Journal Title
Nature Struct. Mol. Biol 15
Pages: 1246-1254
Peer Reviewed
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[Journal Article] Heme induces ubiquitination and degradation of the transcription factor Bach1.2007
Author(s)
Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwai, K., Igarashi, K
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Journal Title
Mol. Cell. Biol 27
Pages: 6962-6971
Peer Reviewed
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[Journal Article] Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells.2006
Author(s)
Ochiai, K., Katoh, Y., Ikura, T., Hoshikawa, Y., Noda, T., Karasuyama, H., Tashiro, S., Muto, A., Igarashi, K
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Journal Title
J. Biol. Chem 281
Pages: 38226-38234
Peer Reviewed
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[Journal Article] Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury.2005
Author(s)
Omura, S., Suzuki, H., Toyofuku, M., Ozono, R., Kohno, N., Igarashi, K
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Journal Title
Genes Cells 10
Pages: 277-285
Peer Reviewed
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[Presentation] Cross-talk between Bach1, NF-kB, and IL-6 in epithelial-mesenchymal transition2009
Author(s)
Brydun, A., Nakanome A., Matsumoto, M., Ota, K., Dohi, Y., Igarashi, K
Organizer
American Association for Cancer Reserch International Conference on Frontiers in Basic Cancer Research
Place of Presentation
Boston, USA
Year and Date
20091008-20091011
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