Innovation of an Enzymatic Reaction Using Ionic Liquids

2009 Fiscal Year Final Research Report

• Project/Area Number: 17073015
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tottori University
• Principal Investigator: ITOH Toshiyuki Tottori University, 大学院・工学研究科, 教授 (50193503)
• Co-Investigator(Kenkyū-buntansha): KAWATSURA Motoi 鳥取大学, 大学院・工学研究科, 准教授 (50360243) ; HAYASE Shuichi 鳥取大学, 大学院・工学研究科, 助教 (50238143) ; IZUMI Yoshikazu 鳥取大学, 工学研究科, 教授 (40026555)
• Project Period (FY): 2005 – 2009
• Keywords: イオン液体 / リパーゼ / 不斉反応 / 酵素活性化

Research Abstract

Innovation of an Enzymatic Reaction Using Ionic Liquids

Research Products

• [Journal Article] イオン液体を反応媒体とする酵素反応の新展開 (2009)
  • Author(s): 伊藤敏幸
  • Journal Title: 有機合成化学協会誌 67 Pages: 143-155
  • Peer Reviewed
• [Journal Article] Design of Alkylsulfate Ionic Liquids for Lubricants (2009)
  • Author(s): Itoh, T.; Watanabe, N.; Inada K.; Ishioka, A.; Hayase, S.; Kawatsura, M.; Minami, I.; Mori, S.
  • Journal Title: Chem. Lett. 38(1) Pages: 64-65
  • Peer Reviewed
• [Journal Article] Remarkable Activation of an Enzyme by (R)-Pyrrolidine-substituted Imidazolium Alkyl PEG Sulfate (2008)
  • Author(s): Abe, Y.; Hirakawa, T.; Nakajima, S.; Okano, N.; Hayase, S.; Kawatsura, M.; Hirose, Y.; Itoh, T.
  • Journal Title: Adv. Synth. Catal. 350 Pages: 1954-1958
  • Peer Reviewed
• [Journal Article] Linker-oriented Design of Binaphthol Derivatives for Optical Resolution Using Lipase-catalyzed Reaction (2008)
  • Author(s): Taniguchi, T.; Fukuba, T.; Nakatsuka, S.; Hayase, S.; Kawatsura, M.; Uno, H.; Itoh, T.
  • Journal Title: J. Org. Chem. 73 Pages: 3875-3884
  • Peer Reviewed
• [Journal Article] Design of Phosphonium Ionic liquids for Lipase-Catalyzed Transesterification (2008)
  • Author(s): Abe, Y.; Kude, K.; Hayase, S.; Kawatsura, M.; Tsunashima, K.; Itoh, T.
  • Journal Title: J. Mol. Catalysis B: Enzymatic 51 Pages: 81-85
  • Peer Reviewed
• [Journal Article] Design of Ionic Liquids as Reaction Media for the Grignard Reaction (2007)
  • Author(s): Itoh, T.; Kude, K.; Hayase, S.; Kawatsura, M.
  • Journal Title: Tetrahedron Lett. 48 Pages: 7774-7777
  • Peer Reviewed
• [Journal Article] Remarkable Acceleration of Lipase-Catalyzed Transesterification Using an Imizadolium PEG-alkyl Sulfate Ionic Liquid (2006)
  • Author(s): Itoh, T.; Matsushita, Y.; Abe, Y.; Han, S-H.; Wada, S.; Hayase, S.; Kawatsura, M.; Takai, S.; Morimoto, M.; Hirose, Y.
  • Journal Title: Chem. Eur. J. 12 Pages: 9228-9237
  • Peer Reviewed
• [Presentation] 化学的に制御された生体触媒反応による環境調和型有機合成反応の開発 (2010)
  • Author(s): 伊藤敏幸
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学〔大阪〕
  • Year and Date: 20100326-20100329
• [Presentation] 酵素反応と化学反応の協調による環境調和型有機合成の展開 (2010)
  • Author(s): 伊藤敏幸
  • Organizer: 有機合成化学協会・協会賞受賞講演会
  • Place of Presentation: 如水会館(東京)
  • Year and Date: 2010-02-19
• [Presentation] Ionic Liquid Type Activating Agent for Enzymes (2009)
  • Author(s): Itoh, T.; Abe, Y.; Hirakawa, T.; Okano, N.; Hayase, S.; Kawatsura, M.
  • Organizer: 3rd Congress on Ionic Liquid Chemistry
  • Place of Presentation: Cairns, Australia
  • Year and Date: 20090531-20090605
• [Book] 酵素開発・利用の最新技術～基礎・解析から改変・高機能化・産業利用まで(監修:小宮山真, 編集:秋吉一成, 中村聡, 中山亨, 津本浩平) (2010)
  • Author(s): 伊藤敏幸
  • Total Pages: 146-153
  • Publisher: 株式会社エヌ・ティー・エス
• [Book] Future Directions in Biocatalysis( Ed. T. Matsuda) (2007)
  • Author(s): Itoh, T.
  • Total Pages: 3-20
  • Publisher: Elsevier Bioscience
• [Book] イオン液体-常識を覆す不思議な塩- (2005)
  • Author(s): 北爪智哉, 淵上寿雄, 沢田英夫, 伊藤敏幸
  • Total Pages: 32-77
  • Publisher: コロナ社
• [Remarks] 研究室ホームページ:
  • URL: http://www.chem.tottori-u.ac.jp/~itoh/
• [Patent(Industrial Property Rights)] フルオロアルキル硫酸アニオンを含有する疎水性を示すイオン性液体
  • Inventor(s): 伊藤敏幸, 立花正満, 古谷浩行
  • Industrial Property Rights Holder: 株式会社カネカ(代表者武田正利)
  • Industrial Property Number: 特願2005-005027