2009 Fiscal Year Final Research Report
Application of Soft Lithography to Mechanobiology
| Project/Area Number |
17076006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Science and Engineering
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
NARUSE Keiji Okayama University, 大学院・医歯薬学総合研究科, 教授 (40252233)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAI Akira 旭川医科大学, 医学部, 教授 (50126869)
MIYAZU Motoi 旭川医科大学, 医学部, 助教 (40396346)
MOHRI Satoshi 川崎医科大学, 医学部, 教授 (00294413)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KATANOSAKA Yuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
IRIBE Gentaro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90284885)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Keywords | 医用マイクロ・ナノマシン / ナノバイオロジー・ナノメディスン |
|---|
| Research Abstract |
In this research project, we focused on mechanosensitive mechanism of mammalian from molecular to individual level. We constructed analysis methods of mechanical and medicinal stimuli using softlithography to construct features measured on the micrometer to nanometer scale, and then employed it into stimuli-response analysis. High-speed atomic force microscope was applied to observe molecular dynamics in aqueous environment with high spatiotemporal resolution, and we elucidated molecular dynamics of the mechanosensitive molecules.
|
-
-
[Journal Article] Improved development of mouse and human embryos using a tilting embryo culture system.2010
Author(s)
Matsuura K, Hayashi N, Kuroda Y, Takiue C, Hirata R, Takenami M, Aoi Y, Yoshioka N, Habara T, Mukaida T, Naruse K
-
Journal Title
Reprod Biomed Online 20
Pages: 358-364
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.2007
Author(s)
Kajiya M, Hirota M, Inai Y, Kiyooka T, Morimoto T, Iwasaki T, Endo K, Mohri S, Shimizu J, Yada T, Ogasawara Y, Naruse K, Ohe T, Kajiya F
-
Journal Title
Am J Physiol Heart Circ Physiol 292(6)
Pages: H2737-H2744
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells.
Author(s)
Iwaki M, Ito S, Morioka M, Iwata S, Numaguchi Y, Ishii M, Kondo M, Kume H, Naruse K, Sokabe M, Hasegawa Y
-
Journal Title
Biochem Biophys Res Commun
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Remarks] 2009. 12. 28日本経済新聞「不妊治療の受精卵培養母胎に似た環境で」
-
[Remarks] 2008. 10ジネコ新聞最先端医療の現場を拝見
-
[Remarks] 2008. 4. 1日刊工業新聞不妊治療で装置出荷卵細胞の培養促進
-
[Remarks] 2008. 1. 7日本産業新聞「受精胚の培養装置」
-
[Remarks] 2007. 12. 11日刊工業新聞「不妊治療の装置開発」
-
[Remarks] 2007. 12. 5日経新聞「泳ぐ力が強い精子選別」
-
[Remarks] 2007. 10. 10山陽新聞「岡山大の卵細胞培養装置大阪の企業に技術移転tlo」
-
[Remarks] 2006. 9. 28日本経済新聞「岡山tlo心筋細胞標本の制作技術移転」
-
[Remarks] 2006. 9. 28山陽新聞「岡山TLO岡山大血管細胞試料技術大阪の企業に移転」
-
[Remarks] 2006. 7. 31大阪日日新聞「バイオベンチャー「ストレックス」が不妊治療でセミナー」
-
[Remarks] 2006. 6. 8共同通信社「刺激与え受精卵の発育促進培養装置を新開発」
-
[Remarks] 2005. 11. 18大阪日日新聞「不妊治療新システム開発の「ストレックス」」
-
-
-
-
-
-
-
