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2009 Fiscal Year Final Research Report

Nanoscience of Photofuctionalized DNA

Research Project

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Project/Area Number 17105005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Functional materials chemistry
Research InstitutionOsaka University

Principal Investigator

MAJIMA Tetsuro  Osaka University, 産業科学研究所, 教授 (00165698)

Co-Investigator(Kenkyū-buntansha) FUJITSUKA Mamoru  大阪大学, 産業科学研究所, 准教授 (40282040)
KAWAI Kiyohiko  大阪大学, 産業科学研究所, 准教授 (50314422)
ENDO Masayuki  大阪大学, 産業科学研究所, 特任准教授 (70335389)
Project Period (FY) 2005 – 2009
KeywordsDNA / 光機能性 / 電荷分離 / 電荷移動 / DNA光損傷
Research Abstract

Photoinduced charge separation and transfer mechanisms in DNA were clarified by using photofuctionalized DNA modified with various chromophores and high efficient and long-lifetime charge separation was established. Development of photoelectric energy conversion devices such as DNA molecular wire and light energy conversion units and highly effective DNA damage methods and creation of DNA photo-nanoscience was tried.

  • Research Products

    (68 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (43 results) (of which Peer Reviewed: 33 results) Presentation (18 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Long-Range Charge Transfer through DNA by Replacing Adenine with Diaminopurine2010

    • Author(s)
      K. Kawai, H. Kodera, T. Majima
    • Journal Title

      J. Am. Chem. Soc. 132(2)

      Pages: 627-630

    • Peer Reviewed
  • [Journal Article] Sequence-independent and rapid long-range charge transfer through DNA2009

    • Author(s)
      K. Kawai, H. Kodera, Y. Osakada, T. Majima
    • Journal Title

      Nature Chem. 1(2)

      Pages: 156-159

    • Peer Reviewed
  • [Journal Article] Importance of protonation state of guanine radical cation during hole transfer in DNA2009

    • Author(s)
      K. Kawai, Y. Osakada, M. Fujitsuka, T. Majima
    • Journal Title

      ChemPhysChem 10(11)

      Pages: 1766-1769

    • Peer Reviewed
  • [Journal Article] "Signal-On" Detection of DNA Charge Transfer at the Single Molecule Level2009

    • Author(s)
      T. Takada, Y. Takeda, M. Fujitsuka, T. Majima
    • Journal Title

      J. Am. Chem. Soc. 131(19)

      Pages: 6656-6657

    • Peer Reviewed
  • [Journal Article] Kinetic Studies of Long-Range Hole Transfer through DNA2009

    • Author(s)
      K. Kawai, T. Majima
    • Journal Title

      Nucleic Acids Symp. Series 53(1)

      Pages: 77-78

  • [Journal Article] Charge Separation in Acridine-and Phenothiazine-Modified DNA2008

    • Author(s)
      K. Kawai, Y. Osakada, M. Fujitsuka, T. Majima
    • Journal Title

      J. Phys. Chem. B 112(7)

      Pages: 2144-2149

    • Peer Reviewed
  • [Journal Article] Photocatalytic Cleavage of Single TiO2/DNA Nanoconjugates2008

    • Author(s)
      T. Tachikawa, Y. Asanoi, K. Kawai, S. Tojo, A. Sugimoto, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Eur. J. 14(5)

      Pages: 1492-1498

    • Peer Reviewed
  • [Journal Article] Mechanism of Charge-Separation in DNA via Hole Transfer through Consecutive Adenines2008

    • Author(s)
      K. Kawai, Y. Osakada, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Eur. J. 14(12)

      Pages: 3721-3726

    • Peer Reviewed
  • [Journal Article] Charge transfer in DNA assembly: effects of sticky end2008

    • Author(s)
      Y. Osakada, K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Commun. 23

      Pages: 2656-2658

    • Peer Reviewed
  • [Journal Article] Kinetic of charge transfer in DNA containing a mismatch2008

    • Author(s)
      Y. Osakada, K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Nucleic Acids Res. 36(17)

      Pages: 5562-5570

  • [Journal Article] Diastereochemically Controlled Porphyrin Dimer Formation on a DNA Duplex Scaffold2008

    • Author(s)
      M. Endo, M. Fujitsuka, T. Majima
    • Journal Title

      J. Org. Chem. 73(3)

      Pages: 1106-1112

    • Peer Reviewed
  • [Journal Article] Conformational regulation of porphyrin dimers on geometric scaffold of duplex DNA2008

    • Author(s)
      M. Endo, M. Fujitsuka, T. Majima
    • Journal Title

      Tetrahedron 64(8)

      Pages: 1839-1846

    • Peer Reviewed
  • [Journal Article] DNAデバイス-DNA中で起こる電荷移動を利用する2008

    • Author(s)
      真嶋哲朗
    • Journal Title

      化学 63(1)

      Pages: 38-40

  • [Journal Article] DNAデバイス-DNA中で起こる電荷移動を利用する2008

    • Author(s)
      高田忠雄、真嶋哲朗
    • Journal Title

      生産と技術 60(1)

      Pages: 55-60

  • [Journal Article] DNA内電荷移動とバイオセンサーへの応用2008

    • Author(s)
      高田忠雄、真嶋哲朗
    • Journal Title

      BIO INDUSTRY 25(3)

      Pages: 61-71

  • [Journal Article] DNA中の電荷移動2008

    • Author(s)
      真嶋哲朗
    • Journal Title

      化学と生物 46(8)

      Pages: 520-522

  • [Journal Article] Single-Molecule Observation of DNA Charge Transfer2007

    • Author(s)
      T. Takada, M. Fujitsuka, T. Majima
    • Journal Title

      Proc. Nat. Acad. Sci. U.S.A. 104(27)

      Pages: 11179-11183

    • Peer Reviewed
  • [Journal Article] Hole Transfer in DNA and Photosensitized DNA Damage: Importance of Adenine Oxidation2007

    • Author(s)
      K. Kawai, Y. Osakada, M. Fujitsuka, T. Majima
    • Journal Title

      J. Phys. Chem. B 111(9)

      Pages: 2322-2326

    • Peer Reviewed
  • [Journal Article] Relationship between Charge Transfer and Charge Recombination Determines Photocurrent Efficiency through DNA Films2007

    • Author(s)
      T. Takada, C. Lin, M. Fujitsuka, T. Majima
    • Journal Title

      Angew. Chem. Int. Ed. 46(35)

      Pages: 6681-6683

    • Peer Reviewed
  • [Journal Article] Hole transfer rates in A-from DNA/2'-OMeRNA hybrid2007

    • Author(s)
      K. Kawai, Y. Osakada, A. Sugimoto, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Eur. J. 13(8)

      Pages: 2386-2391

    • Peer Reviewed
  • [Journal Article] Monitoring G-Quadruplex Structures and G-Quadruplex-ligand Complex by 2-Aminopurine Modified Oligonucleotide2007

    • Author(s)
      T, Kimura, K, Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Tetrahedron 63(17)

      Pages: 3585-3590

    • Peer Reviewed
  • [Journal Article] DNA中の電荷移動速度と情報の関係を明らかにしたい2007

    • Author(s)
      真嶋哲朗
    • Journal Title

      化学 62(1)

      Pages: 23-24

  • [Journal Article] Photochemical Properties of Porphyrin-attached Tabacco Mosaic Virus2007

    • Author(s)
      M. Endo, M. Fujitsuka, T. Majima
    • Journal Title

      Photomed. Photobio. 29

      Pages: 19-20

  • [Journal Article] Photochemical Control of Enzymes Using Photoresponsive Compounds on the Basis of the Interaction Mechanism2007

    • Author(s)
      M. Endo, T. Majima
    • Journal Title

      Photomed. Photobiol. 29

      Pages: 14-15

  • [Journal Article] Thermodynamic properties of branched DNA complexes with full-matched and mismatched DNA strand2006

    • Author(s)
      M. Endo, T. Majima
    • Journal Title

      Chem. Commun.

      Pages: 2329-2331

    • Peer Reviewed
  • [Journal Article] Rapid Long-Distance Hole Transfer through a Consecutive Adenine Sequence2006

    • Author(s)
      T. Takada, K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      J. Am. Chem. Soc. 128(27)

      Pages: 11012-11013

    • Peer Reviewed
  • [Journal Article] High Yield Generation of Long-Lived Charge-Separated State in Diphenylacetylene-Modified DNA2006

    • Author(s)
      T. Takada, K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Angew. Chem. Int. Ed. 45(1)

      Pages: 120-122

    • Peer Reviewed
  • [Journal Article] Charge Transfer through DNA Nanoscaled Assembly Programmable with DNA Building Blocks2006

    • Author(s)
      Y. Osakada, K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 103(48)

      Pages: 18072-18076

    • Peer Reviewed
  • [Journal Article] Effects of reaction rate of radical anion of a photosensitizer with molecular oxygen on the photosensitized DNA damage2006

    • Author(s)
      K. Kawai, Y. Osakada, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Commun.

      Pages: 3918-3920

    • Peer Reviewed
  • [Journal Article] Detection of G-quadruplex-TMPyP4 Complex by 2-Aminopurine Modified Human Telomeric DNA2006

    • Author(s)
      T. Kimura, K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Commun.

      Pages: 401-402

    • Peer Reviewed
  • [Journal Article] Probing of microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides2006

    • Author(s)
      T. Kimura, K. Kawai, T. Majima
    • Journal Title

      Chem. Commun.

      Pages: 1542-1544

    • Peer Reviewed
  • [Journal Article] Formation of Pyrene Dimer Radical Cation at the Minor Groove of DNA2006

    • Author(s)
      K. Kawai, T. Kimura, H. Yoshida, A. Sugimoto, S. Tojo, M. Fujitsuka, T. Majima
    • Journal Title

      Bull. Chem. Soc. Jpn. 79(2)

      Pages: 312-316

    • Peer Reviewed
  • [Journal Article] DNA中の電荷移動とDNAナノサイエンス2006

    • Author(s)
      真嶋哲朗
    • Journal Title

      現代化学 11(11)

      Pages: 25-29

  • [Journal Article] Selective guanine oxidation by UVB-irradiation in telomeric DNA2005

    • Author(s)
      K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Commun

      Pages: 1476-1477

    • Peer Reviewed
  • [Journal Article] Contributions of the Distance-Dependent Reorganization Energy and Proton Transfer Process to Hole Transfer in DNA2005

    • Author(s)
      T. Takada, K. Kawai, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Eur. J. 11(13)

      Pages: 3835-3843

    • Peer Reviewed
  • [Journal Article] Kinetics of Transient End-to-End Contact of Single-Stranded DNAs2005

    • Author(s)
      K. Kawai, H. Yoshida, A. Sugimoto, M. Fujitsuka, T. Majima
    • Journal Title

      J. Am. Chem. Soc. 127(38)

      Pages: 13232-13237

    • Peer Reviewed
  • [Journal Article] DNA Tube Structures Controlled by a Four-Way Branched DNA Connector2005

    • Author(s)
      M. Endo, N.C. Seeman, T. Majima
    • Journal Title

      Angew. Chem. Int. Ed. 44(37)

      Pages: 6074-6077

    • Peer Reviewed
  • [Journal Article] Consecutive adenine sequence are potential targets in photosensitized DNA damage2005

    • Author(s)
      K. Kawai, Y. Osakada, M. Fujitsuka, T. Majima
    • Journal Title

      Chem. Biol. 12(9)

      Pages: 1049-1054

    • Peer Reviewed
  • [Journal Article] Monitoring of Microenvironmental Changes in the Major and Minor Grooves of DNA by Dan Modified Oligonucleotides2005

    • Author(s)
      T. Kimura, K. Kawai, T. Majima
    • Journal Title

      Org. Lett. 7(26)

      Pages: 5829-5832

    • Peer Reviewed
  • [Journal Article] Programmable DNA translation system using cross-linked DNA mediators2005

    • Author(s)
      M. Endo, S. Uegaki, T. Majima
    • Journal Title

      Chem. Commun.

      Pages: 3153-3155

    • Peer Reviewed
  • [Journal Article] Arrangement of DNA Constrained by a Cross-linker2005

    • Author(s)
      M. Endo T. Majima
    • Journal Title

      Org. Biomol. Chem. 3(19)

      Pages: 3476-3478

    • Peer Reviewed
  • [Journal Article] Photosensitized one-electron oxidation of DNA2005

    • Author(s)
      K. Kawai, T. Majima
    • Journal Title

      Pure Appl. Chem. 77(6)

      Pages: 963-975

    • Peer Reviewed
  • [Journal Article] 8-Oxo-7, 8-dihydro-2'-deoxyguanosine Produces a Long-Lived Charge-Separated State During the Photosensitized One-Electron Oxidation of DNA Resulting in Efficient and Exclusive Degradation

    • Author(s)
      K. Kawai, E. Matsutani, T. Majima
    • Journal Title

      Chem Commun. (in press)

    • Peer Reviewed
  • [Presentation] Asian Symposium on Organic Materials for Electronics and Photonics (ASOMP 2009) and 7th International OLED and PLED Materials Workshop in Taipei2009

    • Author(s)
      T. Majima
    • Organizer
      DNA Electronics
    • Place of Presentation
      Taiwan University, Taipei, Taiwan
    • Year and Date
      20091213-20091215
  • [Presentation] 光増感DNA損傷2009

    • Author(s)
      真嶋哲朗
    • Organizer
      2009光生物学協会年会(岡崎)
    • Place of Presentation
      自然科学研究機構、岡崎
    • Year and Date
      20090819-20090820
  • [Presentation] Charge Transfer in DNA2009

    • Author(s)
      T. Majima
    • Organizer
      Kyudai International Symposium on Photo and Supramolecular Chemistry
    • Place of Presentation
      Kyushu University, Fukuoka
    • Year and Date
      2009-03-07
  • [Presentation] Charge Transfer in DNA2008

    • Author(s)
      T. Majima
    • Organizer
      2008 Korea-Japan Symposium on Frontier Photoscience
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20080924-20090927
  • [Presentation] Charge Transfer in DNA2008

    • Author(s)
      K. Kawai, M. Fujitsuka, T. Majima
    • Organizer
      2nd Asia-Pacific Symposium on Radiation Chemistry (APSRC-2008)
    • Place of Presentation
      Waseda University, Tokyo
    • Year and Date
      20080829-20090901
  • [Presentation] Charge Transfer in DNA2008

    • Author(s)
      T. Majima, K. Kawai, M. Fujitsuka
    • Organizer
      236th ACS National Meeting
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      20080817-20080821
  • [Presentation] Charge Transfer in DNA2008

    • Author(s)
      T. Majima
    • Organizer
      10th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Kitashiobara-Mura, Fukushima
    • Year and Date
      20080608-20080613
  • [Presentation] DNA Devices Based on Charge Transfer in DNA2008

    • Author(s)
      T. Majima
    • Organizer
      The 3rd CNU-SANKEN Joint Symposium on Advanced Materials Science
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      20080227-20080228
  • [Presentation] Charge Transfer in DNA2007

    • Author(s)
      T. Majima
    • Organizer
      2007 Photochemistry Gordon Research Conference
    • Place of Presentation
      Bryant University, Smithfield, Rhode Island, USA
    • Year and Date
      20070708-20070713
  • [Presentation] Charge Transport in DNA2006

    • Author(s)
      T. Majima
    • Organizer
      CLUSTOXDNA Meeting on the Chemistry and Biochemistry of Oxidative DNA Damage
    • Place of Presentation
      Gandia, Valencia, Spain
    • Year and Date
      20061028-20061101
  • [Presentation] Photosensitized one electron oxidation of DNA towards photodynamic therapy2006

    • Author(s)
      T. Majima
    • Organizer
      International Symposium on Radical Ion Reactivity
    • Place of Presentation
      Monteporzio, Rome, Italy
    • Year and Date
      20060702-20060706
  • [Presentation] Mechanism of Photosensitized DNA Damage: Hole Transfer in DNA and the Role of Oxygen2006

    • Author(s)
      K. Kawai Y. Osakada, M. Fujitsuka, T. Majima
    • Organizer
      21st IUPAC Symposium on Photochemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      20060402-20060407
  • [Presentation] DNAのビーム機能化学2006

    • Author(s)
      真嶋哲朗
    • Organizer
      日本化学会郡山地区講演会
    • Place of Presentation
      日本大学工学部、郡山、福島
    • Year and Date
      2006-11-17
  • [Presentation] Hole transfer in DNA studied by laser flash photolysis of chemically modified DNA2005

    • Author(s)
      T. Majima
    • Organizer
      PACIFICHEM 2005
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      20051215-20051220
  • [Presentation] Construction of DNA supramolecules, First Joint symposium between College of Natural Science2005

    • Author(s)
      T. Majima
    • Organizer
      ational Taiwan Normal University and Osaka University
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20051126-20051127
  • [Presentation] Construction of artificially controlled nano-scale DNA structures2005

    • Author(s)
      T. Majima
    • Organizer
      First Joint symposium between the College of Natural Sciences of CNU and the SANKEN of Osaka University on Advanced Materials Science
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      20051031-20051103
  • [Presentation] Photosensitized one-electron oxidation of DNA2005

    • Author(s)
      T. Majima
    • Organizer
      2005 Annual Meeting Korean Society of Photoscience (12th Photoscience Symposium)
    • Place of Presentation
      Daejon, Korea
    • Year and Date
      20050609-20060610
  • [Presentation] Direct Observation of Hole Transfer through Double Helical DNA over 100 A2005

    • Author(s)
      T. Majima
    • Organizer
      4th Asian Photochemistry Conference (APC-2005)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20050105-20050110
  • [Book] Radicals in Nucleic Acids,Volume 2 in the Wiley Series of Reactive Intermediates in Chemistry and Biology, Kinetics of Long-Range Oxidative Electron Transfer through DNA2009

    • Author(s)
      K. Kawai T. Majima
    • Total Pages
      191-210
    • Publisher
      John Wiley & Sons, Inc
  • [Book] New research on DNA damage2009

    • Author(s)
      K. Kawai, T. Majima
    • Total Pages
      221-236
    • Publisher
      Nova
  • [Book] Charge Transfer in DNA2005

    • Author(s)
      K. Kawai T. Majima
    • Total Pages
      117-132
    • Publisher
      Wiley-VCH
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/mec/index.html

  • [Patent(Industrial Property Rights)] 一塩基多型の検出方法2010

    • Inventor(s)
      真嶋哲朗、川井清彦
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特許特願2010-9822.
    • Filing Date
      2010-01-20
  • [Patent(Industrial Property Rights)] 二本鎖DNAの電荷移動を利用したDNA一分子蛍光測定による一塩基多型の検出法2006

    • Inventor(s)
      真嶋哲朗、高田忠雄、川井清彦、藤塚守
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特許特願2007-6829.
    • Filing Date
      2006-01-16
  • [Patent(Industrial Property Rights)] 核酸微小ブロックを利用した核酸エレクトロニクス2006

    • Inventor(s)
      真嶋哲朗、川井清彦、小阪田泰子、藤塚守
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特許特願2006-291734
    • Filing Date
      2006-10-26

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Published: 2011-06-18   Modified: 2016-04-21  

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