2009 Fiscal Year Final Research Report
Molecular genetic analysis of cellular response to transcription-blocking DNA damage and its defective disorders
| Project/Area Number |
17109006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human genetics
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| Research Institution | Osaka University |
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Principal Investigator |
TANAKA Kiyoji Osaka University, 大学院・生命機能研究科, 教授 (80144450)
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| Co-Investigator(Kenkyū-buntansha) |
SAIJO Masafumi 大阪大学, 大学院・生命機能研究科, 准教授 (90221986)
HORIBATA Katsuyoshi 大阪大学, 大学院・生命機能研究科, 助教 (40402995)
NARITA Takashi 大阪大学, 大学院・生命機能研究科, 助教 (50437399)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 色素性乾皮症 / コケイン症候群 / DNA修復 / 転写 / 転写と共役した修復 |
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| Research Abstract |
Nucleotide excision repair (NER) is a versatile DNA repair system that removes a wide range of DNA lesions including UV-damage and oxidative DNA damage. The importance of NER is indicated by the study of xeroderma pigmentosum patients who show a high incidence of skin cancer and neurological abnormalities, and are deficient in NER. Transcription-blocking DNA damage in active genes is repaired by transcription-coupled NER (TCR). There are two autosomal recessive disorders that are specifically deficient in TCR : Cockayne syndrome (CS) and UV-sensitive syndrome (UV^sS). CS is characterized by photosensitivity and abnormal physical and neurological development. On the other hand, UV^sS patients show photosensitivity and mild freckling with no skin tumors. In this study, molecular mechanism of TCR and molecular pathogenesis of XP, CS and UV^sS have been analyzed.
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Research Products
(25 results)
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[Journal Article] Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair.2008
Author(s)
Isao Kuraoka, Shinsuke Ito, Tadashi Wada, Mika Hayashida, Lily Lee, Masafumi Saijo, Yoshimichi Nakatsu, Megumi Matsumoto, Tsukasa Matsunaga, Hiroshi Handa, Jun Qin, Yoshihiro Nakatani, Kiyoji Tanaka.
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Journal Title
Journal of Biological Chemistry 283
Pages: 940-950
Peer Reviewed
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