2008 Fiscal Year Final Research Report
Elucidation of tolerance mechanism against peripheral target antigens in autoimmune diseases
| Project/Area Number |
17109012
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
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Principal Investigator |
AMAGAI Masayuki Keio University, 医学部, 教授 (90212563)
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| Co-Investigator(Kenkyū-buntansha) |
KOYASU Shigeo 慶應義塾大学, 医学部, 教授 (90153684)
KUWANA Masataka 慶應義塾大学, 医学部, 准教授 (50245479)
ISHIKO Akira 慶應義塾大学, 医学部, 准教授 (10202988)
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| Project Period (FY) |
2005 – 2008
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| Keywords | 自己免疫 / 免疫寛容 / モデルマウス / 天疱瘡 / カドヘリン |
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| Research Abstract |
The purpose of this study is to clarify the mechanisms of peripheral tolerance using pemphigus vulgaris which is mediated by IgG autoantibodies against desmoglein 3 (Dsg3) as a model disease. Dsg3-specific T cells showed pathogenic heterogeneity in anti-Dsg3 IgG production and IL-4 was a key cytokine in this process. A single helper T cell clone was sufficient to commit polyclonal naive B cells to produce pathogenic IgG. Mature Dsg3-specific B cells were eliminated via a Fas-mediated process in a CD4^+ T cell dependent fashion when tissue damages were induced by pathogenic IgG, suggesting a novel peripheral B cell tolerance mechanism.
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Research Products
(47 results)
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[Journal Article] Development of tissue-targeting hemagglutinating virus of Japan envelope vector for successful delivery of therapeutic gene to mouse skin.2007
Author(s)
Kawachi M, Tamai K, Saga K, Yamazaki T, Fujita H, Shimbo T, Kikuchi Y, Nimura K, Nishifuji K, Amagai M, Uitto J, Kaneda Y
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Journal Title
Hum Gene Ther 18(10)
Pages: 881-894
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[Journal Article] Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just 'witnesses of disease'?2006
Author(s)
Amagai M, Ahmed A R, Kitajima Y, Bystryn J C, Milner Y, Gniadecki R, Hertl M, Pincelli C, Fridkis-Hareli M, Aoyama Y, Frusic-Zlotkin M, Muller E, David M, Mimouni D, Vind-Kezunovic D, Michel B, Mahoney M, Grando S
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Journal Title
Exp Dermatol 15
Pages: 815-831
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