Heat Immunotherapy using dendritic cell for squamous cell carcinoma

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 17390534
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University (2006-2007); Nagoya University (2005)
• Principal Investigator: IWAI Tohnai Yokohama City University, School of Medicine, Professor (50172127)
• Co-Investigator(Kenkyū-buntansha): HONDA Hiroyuki Nagoya University, School of Engineering, Professor (70209328) ; MITSUDO Kenji Yokohama City University, School of Medicine, Associate Professor (70303641) ; NISHIGUCHI Hiroaki Nagoya University, School of Medicine, Assistant Professor (00335043) ; ITO Akira Kyusyu University, School of Engineering, Professor (60345915) ; UEDA Minoru Nagoya University, School of Medicine, Professor (00151803)
• Project Period (FY): 2005 – 2007
• Keywords: Squamous cell carcinoma / dendriticcell(DC) / Hyperthermia / Mgnetic cationic liposome (MCL) / Cancer immunity

Research Abstract

This study is basic study of immunothermotherapy combined with interstitial hyperthermia and dendritic cell (DC) of antigen presenting cell for head and neck squamous cell carcinoma. We have recently developed magneticparticles with a cationic liposomal membrane, 'magnetic cationic liposomes' (MCLs) ,with have the ability to target cancer cells and heat them intracellularly. MCLs are coated colloidal magnetite (Fe3O4) with a liposomal membrane. MHC class I, II, CD80 and CD86 increased after hyperthermia in co-cultured SCC VII cells and DC. The maturity of DC was observed after hyperthermia combined with DC in SCC VII mouse. Tumor-specific immunity was activated by the maturity of CTL activity and NK activity.

Research Products

• [Journal Article] Effect of heat therapy using magnetic nanoparticles conjugated with cationic liposomes on prostate tumor in bone (2008)
  • Author(s): Kawai N, Futakuchi M, Yoshida T, Ito A, Sato S, Naiki T, Honda H, Shirai T, Kohri K
  • Journal Title: Prostate 26 Pages: 136-140
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heat Immunotherapy with Heat Shock Protein Expression by Hyperthermia Using Magnetite Nanoparticles (2007)
  • Author(s): A.Ito, T.Kobayashi, H.Honda
  • Journal Title: Annals of Cancer Research and Therapy 15(2) Pages: 27-34
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 4-S-Cysteaminylphenol-loadecl magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma. (2007)
  • Author(s): Ito A, Fujioka M, Yoshida T, Wakamatsu K, Ito S, Yamashita T, Jimbow K, Honda H
  • Journal Title: Cancer Science 98(3) Pages: 424-430
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 4-S-Cysteaminylphenol-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma (2007)
  • Author(s): Ito, A., Fujioka, M., Yoshida, T., Wakamatsu, K., Ito, S.,Yamashita, T., Jimbow, K., Honda, H
  • Journal Title: Cancer Science 98 Pages: 424-430
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] heat immunotherapy with heat shock protein expression by hyperthermia (2007)
  • Author(s): Ito, A., Kobayashi, T., Honda, H
  • Journal Title: Annals of Cancer Research and Therapy 15 Pages: 27-34
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chemotherapy using intra-arterial infusion for oral cancer (2006)
  • Author(s): Tohnai, I
  • Journal Title: Nagoya J Med Sci 68 Pages: 101-108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ハイパーサーミアの併用で治療可能比の向上が期待される疾患 頭頸部癌 進展口腔癌に対する新しい超選択的動注法を用いた温熱化学放射線療法 (2007)
  • Author(s): 藤内 祝
  • Organizer: 第24回日本ハイパーサーミヤ学会
  • Place of Presentation: 前橋市
  • Year and Date: 20070914-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Thermochemoradiotherapy using new superselective intraarterial infusion for advanced oral cancer (2007)
  • Author(s): Tohnai, I., Mitsudo, K., Fukui, T., Saito, M., Shigetomi, T
  • Organizer: 24th Annumal Meeting of Japanese of Hyperthermic Oncology
  • Place of Presentation: Maebashi, Japan
  • Year and Date: 20070900
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Immunothermotherapy using dendritic cell (DC) for squamous cell carcinoma (2006)
  • Author(s): Saito, M., Mitsudo, K., Yamamoto, N., Tohnai, I
  • Organizer: 4th Tokai-Hakuriku Hyperthermic Oncology
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Concurrent chemoradiotherapy using new superselective intraarterial infusion for oral cancer (2006)
  • Author(s): Tohnai, L
  • Organizer: 11th International Congress on Oral Cancer
  • Place of Presentation: Grado, Italy.
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より