2006 Fiscal Year Final Research Report Summary
Assessment of the health effects of fumes generated from frying oil by DNA micro array
| Project/Area Number |
17580102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Koriyama Women's University |
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Principal Investigator |
FUJIMOTO Kenshiro Koriyama Women's University, School of Economics, Professor (00005620)
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| Co-Investigator(Kenkyū-buntansha) |
HIROI Masaru Koriyama Women's University, School of Economics, Professor (30048847)
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| Project Period (FY) |
2005 – 2006
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| Keywords | frying oil / triacylglycerol / diacylglycerol / fume / volatile aldehydes / cyototoxicity / gene expression / micro array |
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| Research Abstract |
The health effects of the fumes generated from potato frying were assessed by the incubation with cultivated rat hepatocytes and the DNA microarray technology. Potatoes were 'fried using the salad oil (TAG) or the diacylglycerol-rich oil (DAG) and the fumes were collected in the cold trap to incubated with the rat hepatocytes or introduced to a glass vessel-in which mice were kept to assess the effect on gene expression-pattern in the liver. Chemical analysis and cytotoxicity assessment showed that the major cytotoxic substances could be volatile aldehydes in both oils. Expression of many genes in the liver such as metallothionein and lipin were commonly accelerated with disposure to the fumes from two frying oils, but the expression of some genes related to interferon was accelerated more remarkably by the fume from DAG than that from TAG.
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