Role of a new Toll-like receptor-related signaling molecule in immunereactions in lung and airway

2008 Fiscal Year Final Research Report

• Project/Area Number: 17590773
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hirosaki University
• Principal Investigator: IMAIZUMI Tadaatsu Hirosaki University, 大学院・医学研究科, 助教 (90232602)
• Co-Investigator(Kenkyū-buntansha): 吉田 秀見 弘前大学, 大学院・医学研究, 講師 (40201008) ; 佐藤 敬 弘前大学, 大学院・医学研究科, 教授 (20125438) ; 高梨 信吾 弘前大学, 大学院・医学研究科, 准教授 (10187982) ; 亀井 克彦 千葉大学, 真菌医学研究センター, 教授 (10214545)
• Project Period (FY): 2005 – 2008
• Keywords: Toll 様受容体 / RIG-I / 免疫応答 / 感染症 / 炎症性疾患

Research Abstract

Retinoic acid-inducible gene-I (RIG-I) は、気道上皮細胞、血管内皮細胞、マクロファージなどの肺・気道の構成細胞で産生されること、また、ウイルスや細菌の感染により活性化されて、下流のケモカインの発現を調節することにより、肺・気道における免疫応答や炎症反応を誘導することこと、が明らかになった。さらに、気道における免疫応答のみならず、関節リウマチなどの自己免疫疾患の病態にも関与していることが明らかになった。

Research Products

• [Journal Article] The levels of retinoic acid-induciblegene-I are regulated by heat shock protein90-α (2009)
  • Author(s): Matsumiya T, Imaizumi T, Yoshida H,Satoh K, Topham MK, Stafforini DM
  • Journal Title: J Immunol 182 Pages: 2717-2725
  • Peer Reviewed
• [Journal Article] Tumor-necrosisfactor-α induces retinoicacid-inducible gene-I in rheumatoidfibroblast-like synoviocytes (2009)
  • Author(s): Imaizumi T, Matsumiya T, Yoshida H,Naraoka T, Uesato R, Ishibashi Y, Ota K, Toh S, Fukuda S, Satoh K
  • Journal Title: Immunol Lett 122 Pages: 89-93
  • Peer Reviewed
• [Journal Article] Regulationof IkB kinase-related kinases andantiviral responses by tumor suppressor CYLD (2008)
  • Author(s): Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC
  • Journal Title: J Biol Chem 283 Pages: 18621-18626
  • Peer Reviewed
• [Journal Article] Involvement of retinoic acid-induciblegene-I (RIG-I) in inflammation ofrheumatoid fibroblast-like synoviocytes (2008)
  • Author(s): Imaizumi T, Arikawa T, Sato T, Uesato R, Matsumiya T, Yoshida H, Ueno M, Yamasaki S, Nakajima T, Hirashima M, Sakata K, Ishibashi Y, Toh S, Ohyama C, Satoh K
  • Journal Title: Clin Exp Imunol 153 Pages: 240-244
  • Peer Reviewed
• [Journal Article] Retinoicacid-inducible gene-I is induced by interferon-γ and regulates CXCL11expression in HeLa cells (2008)
  • Author(s): Yuzawa E, Imaizumi T, Matsumiya T, Yoshida H, Fukuhara R, Kimura H, Fukui A,Tanji K, Mori F, Wakabayashi K, Fujii S, Mizunuma H, Satoh K
  • Journal Title: Life Sci 82 Pages: 670-675
  • Peer Reviewed
• [Journal Article] Expression of mRNA forfunctional molecules in urinary sedimentin glomerulonephritis (2008)
  • Author(s): Tsugawa K, Suzuki K, Oki E, Imaizumi T, Ito E, Tanaka H
  • Journal Title: Pediatr Nephrol 23 Pages: 395-401
  • Peer Reviewed
• [Journal Article] Negative feedback regulation ofRIG-I-mediated anti-viral signaling byinterferon-induced ISG15 conjugation (2008)
  • Author(s): Kim MJ, Hwang SY, Imaizumi T, Yoo JY
  • Journal Title: J Virol 82 Pages: 1474-83
  • Peer Reviewed
• [Journal Article] Interferon-γ upregulates retinoicacid-inducible gene-I in humanpericardial mesothelial cells (2007)
  • Author(s): Hatakeyama M, Imaizumi T, Terasaki F,Mori F, Tanji K, Sato F, Kijima H, Suma H,Wakabayashi K, Yoshida H, Fukuda I, SatohK
  • Journal Title: Acta Cardiol 62(6) Pages: 551-555
  • Peer Reviewed
• [Journal Article] Expression of retinoicacid-inducible gene-I in lupus nephritis (2007)
  • Author(s): Suzuki K, Imaizumi T, Tsugawa K, Ito E, Tanaka H
  • Journal Title: Nephrol Dial Transplant 22 Pages: 2407-2409
  • Peer Reviewed
• [Journal Article] Retinoic acid-inducible gene-Imediates RANTES/CCL5 expression in U373MGhuman astrocytoma cells stimulated withdouble-stranded RNA (2007)
  • Author(s): Yoshida H, Imaizumi T, Lee SJ, Tanji K,Sakaki H,Matsumiya T, Ishikawa A, Taima K,Yuzawa E, Mori F, Wakabayashi K, Kimura H,Satoh K
  • Journal Title: Neurosci Res 58 Pages: 199-206
  • Peer Reviewed
• [Journal Article] Expression of retinoicacid-inducible gene-I (RIG-I) inmacrophages : possible involvement ofRIG-I in atherosclerosis (2007)
  • Author(s): Imaizumi T, Yagihashi N, Kubota K,Yoshida H, Sakaki H, Yagihashi S, KimuraH, Satoh K
  • Journal Title: J Atheroscler Thromb 14 Pages: 51-55
  • Peer Reviewed
• [Journal Article] Cytokine modulation of retinoicacid-inducible gene-I (RIG-I) expressionin human epidermal keratinocytes (2007)
  • Author(s): Kitamura H, Matsuzaki Y, Kimura K,Nakano H, Imaizumi T, Satoh K, Hanada K
  • Journal Title: J Dermatol Sci 45 Pages: 127-134
  • Peer Reviewed
• [Journal Article] Regulation of CXCL-8 (Interleukin 8) induction by ds RNA signaling pathways during Hepatitis Cvirus infection (2007)
  • Author(s): Wagoner J, Austin M, Green J, ImaizumiT, Casola A, Brasier A, Khabar KS, WakitaT, Gale M Jr, Polyak SJ
  • Journal Title: J Virol 81 Pages: 309-318
  • Peer Reviewed
• [Journal Article] Retinoic acid-inducible gene-I isinduced in gingival fibroblasts by LPS orpoly IC : possible roles in interleukin-1β,-6 and -8 expression (2006)
  • Author(s): Kubota K, Sakaki H, Imaizumi T, Nakagawa H, Kusumi A, Kobayashi W, Satoh K, Kimura H
  • Journal Title: Oral Microbiol Immunol 21 Pages: 399-406
  • Peer Reviewed
• [Journal Article] Listeriamonocytogenes induces the expression ofretinoic acid-inducible gene-I (2006)
  • Author(s): Imaizumi T, Sashinami H, Mori F, Matsumiya T, Yoshida H, Nakane A, Wakabayashi K, Oyama C, Satoh K
  • Journal Title: Microbiol Immunol 50 Pages: 811-815
  • Peer Reviewed
• [Journal Article] EB virus-encoded RNAs (EBERs)are recognized by RIG-I and activatesignaling to induce type I IFN (2006)
  • Author(s): Samanta M, Iwakiri D, Kanda T, Imaizumi T, Takada K
  • Journal Title: EMBO J 25 Pages: 4207-4214
  • Peer Reviewed
• [Journal Article] RIG-Iand mda-5 are involved in influenza Avirus-induced expression of antiviralcytokines (2006)
  • Author(s): Siren J, Imaizumi T, Sarker D, Pietila T, Noah D L, Lin R, Hiscott J, Krug RM,Fisher PB, Julknen I, Matikainen S
  • Journal Title: Microbes Infect 8 Pages: 2013-2020
  • Peer Reviewed
• [Journal Article] Expression of IP-10/CXCL10 is upregulated by double-stranded RNA in BEAS-2B bronchialepithelial cells (2006)
  • Author(s): Taima K, Imaizumi T, Yamashita K, Ishikawa A, Fujita T, Yoshida H, Takanashi S, Okumura K, Satoh K
  • Journal Title: Respiration 73(3) Pages: 360-364
  • Peer Reviewed
• [Journal Article] Shared and uniquefunctions of the DExD/H-box helicasesRIG-I, MDA5 and LGP2 in antiviral innateimmunity (2005)
  • Author(s): Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E,Loo YM, Gale Jr. M, Akira S, Yonehara S, Kato A, Fujita T
  • Journal Title: J Immunol 175 Pages: 2851-2858
  • Peer Reviewed
• [Journal Article] Involvement of RIG-Iin IFN-γ/STAT1 signaling pathway inBEAS-2B cells (2005)
  • Author(s): Imaizumi T, Kumagai M, Taima K, Fujita T, Yoshida H, Satoh K
  • Journal Title: Eur Resp J 25 Pages: 1077-1083
  • Peer Reviewed
• [Presentation] 関節リウマチにおけるretinoic acid-inducible gene-I (RIG-I)の意義 (2008)
  • Author(s): 今泉忠淳
  • Organizer: 弘前医学会総会
  • Place of Presentation: 弘前市
  • Year and Date: 2008-06-15
• [Presentation] Double-stranded RNA inducesthe expression of retinoic acid-inducible gene-I in culturedastrocytes (2006)
  • Author(s): 今泉忠淳
  • Organizer: International Conference of Neuroimmunology
  • Place of Presentation: 名古屋市
  • Year and Date: 2006-10-18
• [Presentation] 免疫応答・炎症反応を制御する新しい因子retinoic acid-induciblegene-I (RIG-I) (2006)
  • Author(s): 今泉忠淳
  • Organizer: 弘前大学遺伝子実験施設シンポジウム
  • Place of Presentation: 弘前大学
  • Year and Date: 2006-06-30
• [Presentation] Listeria monocytogenesinduces the expression of retinoicacid-inducible gene-I (2006)
  • Author(s): 今泉忠淳
  • Organizer: International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: 京都市
  • Year and Date: 2006-06-21
• [Presentation] BEAS-2B 気道上皮細胞における IFN-γ/STAT1 へのRIG-I の関与 (2005)
  • Author(s): 今泉忠淳
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸市
  • Year and Date: 2005-10-20