2006 Fiscal Year Final Research Report Summary
Study for the pathogenesis of neuropathy with Desert hedgehog gene mutation and development for the treatment
| Project/Area Number |
17590884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kagoshima University |
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Principal Investigator |
UMEHARA Fujio Kagoshima University, Graduate School of Medical and Dental Sciences, Assistant Professor, 大学院医歯学総合研究科, 講師 (20271140)
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| Co-Investigator(Kenkyū-buntansha) |
TAKASHIMA Hiroshi Kagoshima University, Graduate School of Medical and Dental Sciences, Research Associate, 大学院医歯学総合研究科, 助手 (80372803)
ARIMURA Kimiyoshi Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院医歯学総合研究科, 助教授 (20159510)
OSAME Mitsuhiro Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院医歯学総合研究科, 教授 (10041435)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Desert hedgehog / peripheral nerve / diabetes mellitus / Schwann cell / hereditary neuropathy |
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| Research Abstract |
1. Analysis of Desert hedgehog signaling pathway in peripheral nervous system
We found that Dhh receptor patched(ptc)2 was detected in adult sciatic nerves using RT-PCR, however, ptc1 was undetectable under the same experimental condition. We found that the Dhh-Ptc2 signaling pathway may be involved in the maintenance of adult nerves and may be one of the factors that directly or indirectly determines the response of peripheral nerves to injury.
2. Analysis of Dhh function in the central nervous system
We found that Dhh KO male mice exhibited prolonged immobility time compared with wild-type male mice in the for forced swimming test, and showed enhanced inhibition in the Vogel's conflict model. These findings suggest that Dhh KO male mice exhibited enhanced anxiety and depressive behavior compared with wild-type male mice.
3. Role of Dhh in diabetic neuropathy
We found that Dhh mRNA levels are down regulated in sural nerves of human diabetic neuropathies.
4. Report of minifascicular neuropathy in Italy
We reported a case of polyneuropathy with minifascicular formation in Italy.
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[Journal Article] MRI studies of spinal visceral larva migrans syndrome.2006
Author(s)
Fujio Umehara, Hideki Ookatsu, Daisuke Hayashi, Akifumi Uchida, Yukari Douchi, H.Kawabata, Rina Goto, Akihiro Hashiguchi, Eiji Matsuura, Ryuichi Okubo, Itsuro Higuchi, Kimiyoshi Arimura, Y.Nawa, Mitsuhiro Osame.
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Journal Title
J Neurol Sci 249
Pages: 7-12
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Early clinical signs and imaging findings in Gerstmann-Straussler-Scheinker syndrome (Pro102Leu).2006
Author(s)
Hitoshi Arata, Hiroshi Takashima, Ryuki Hirano, Hisanori Tomimitsu, Koichi Machigashira, Kotaro Izumi, Mitsuro Kikuno, A.R. Ng, Fujio Umehara, Takayo Arisato, Ryuichi Ohkubo, Y. Nakabeppu, M. Nakajo, Mitsuhiro Osame, Kimiyoshi Arimura.
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Journal Title
Neurology 66
Pages: 1672-1678
Description
「研究成果報告書概要(欧文)」より
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