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2006 Fiscal Year Final Research Report Summary

The role of IL-18 for eosinophillic rhinosinusitis.

Research Project

Project/Area Number 17591810
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHyogo College of Medicine

Principal Investigator

FUKAZAWA Keijiro  Hyogo College of Medicine, Faculty of Medicine, Asocciate professor, 医学部, 助教授 (50278842)

Co-Investigator(Kenkyū-buntansha) SAKAGAMI Masafumi  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (10170573)
OKAMURA Haruki  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (60111043)
Project Period (FY) 2005 – 2006
KeywordsIL-18 / bronchial asthma / eoshinophil / rhinosinusitis / nasal polyp
Research Abstract

We experienced 141 patients who had chronic sinusitis for 2 years. 31 (22.0%) of the 141 patients who had chronic rhino sinusitis with eosinophillia or bronchial asthma for 2 years were studied. Eight of 31 asthmatic patients presented aspirin-induced asthma. They were 19 male and 12 female and the mean age was 51.3 years old (24-76 years old). The percentages of eosinophils of the patients were from 3.9 to 49.8 (mean: 11.8%), and 29 of 31 patient had over 10% epsinophils. All of the patients were undergone endoscopic endonasal sinus surgery bilaterally. The pieces of nasal polyps, the mucosa of inferior turbinates and olfactory clefts were processed for light and transmission electronmicroscopy. Some of the specimens were processed for immunohistochemistry of IL-18 receptor. And some of the tissue from the nasal polyps and mucosa from the inferior turbinates were processed for ELISA of IL-4, 5.
The nasal polyps and the mucosa of the olfactory cleft showed the infiltration of numerous eosinophils into the sub mucosal tissue. On the other hand, in the olfactory neuroepthelium, there were no infiltration of eosinophils and most olfactory cells were remained intact. The transmission electronmicroscopy showed the aggregated eosinophils contained the characteristic vesicles within its cytoplasm
Unfortunately, we could not detect IL-18 receptor in the nasal polyps by immunohistochemistry. ELISA of IL-4,5 indicated high titer of the IL's. We concluded that severe infiltration of eosinophils should lead to ocur the nasal polypsis and edema of the olfactory clefts. For IL-18 elucidation, we want to push forward study including new procedure in future.

  • Research Products

    (9 results)

All 2006 2005

All Journal Article (9 results)

  • [Journal Article] 慢性副鼻腔炎による嗅覚障害に対するESSの効果II-気管支喘息合併例について-2006

    • Author(s)
      深澤啓二郎
    • Journal Title

      MB ENTONI 64

      Pages: 29-33

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 慢性副鼻腔炎の治療戦略-手術治療-2006

    • Author(s)
      深澤啓二郎
    • Journal Title

      JOHNS 22・1

      Pages: 27-31

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 生活臭アンケートによる嗅覚機能評価について2006

    • Author(s)
      深澤啓二郎
    • Journal Title

      日本味と匂学会誌 13・3

      Pages: 609-612

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 嗅覚障害の治療、"におい"特集12006

    • Author(s)
      深澤啓二郎
    • Journal Title

      脳21 9・2

      Pages: 55-60

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The effect of ESS on olfactory loss in chronic rhinosinusitis with bronchial asthma. in Japanese2006

    • Author(s)
      Keijiro Fukazawa
    • Journal Title

      MB ENTONI 64

      Pages: 26-30

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The surgical approach for chronic rhinosinusitis. in Japanese.2006

    • Author(s)
      Keijiro Fukazawa
    • Journal Title

      JOHNS 22

      Pages: 27-31

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The evaluation of olfactory acuity with questionnaire of odor. in Japanese.2006

    • Author(s)
      Keijiro Fukazawa
    • Journal Title

      Journal of taste and smell 13

      Pages: 609-612

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 嗅覚障害.ステロイド薬の正しい使い方2005

    • Author(s)
      深澤啓二郎
    • Journal Title

      MB ENTONI 48

      Pages: 56-60

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] How to use the steroids for olfactory loss, in Japanese.2005

    • Author(s)
      Keijiro Fukazawa
    • Journal Title

      MB ENTONI 48

      Pages: 56-60

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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