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2006 Fiscal Year Final Research Report Summary

Volumetric MR Imaging of Head and Neck Cancer: Correlation between Tumor Volume and Survival.

Research Project

Project/Area Number 17591969
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNagasaki University

Principal Investigator

KIMURA Yasuo  Nagasaki University, Graduate School of Biomedical Sciences, instructor, 大学院医歯薬学総合研究科, 助手 (30253686)

Co-Investigator(Kenkyū-buntansha) SUMI Misa  Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor, 大学院医歯薬学総合研究科, 助教授 (90284702)
TAKAGI Yukinori  Nagasaki University, Graduate School of Biomedical Sciences, instructor, 大学院医歯薬学総合研究科, 助手 (30295084)
SATO Eida  Nagasaki University, Graduate School of Biomedical Sciences, instructor, 大学院医歯薬学総合研究科, 助手 (80325662)
NAKAMURA Takashi  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (30172406)
Project Period (FY) 2005 – 2006
KeywordsMRI / Tumor Volume / Head and Neck Cancer
Research Abstract

The size of the primary lesion and the lymph node metastasis are critical indicators for the patient prognosis. Here we sought to assess the correlation between these two prognostic parameters in patients with pharyngeal or oral cancer. We studied 66 patients with oral (n = 42) or pharyngeal (n = 24) cancer. Of these patients, 26 (10 with oral and 15 with pharyngeal carcers) were associated with lymph node metastases. We measured the volumes of the primary lesions as gadolinium-enhanced areas on T1-weighted images and as hyperintense areas on fat-suppressed (STIR) T2-weighted images. Histologically confirmed metastatic nodes were correlated with those on fat-suppressed T2-weighted MR images. The volume measurements by the two MR imaging sequences yielded similar results. The tumor volumes were well correlated with the T category for the primary lesion both in oral and pharyngeal cancers. The volumes of the oropharhngeal and hypopharyngeal cancers were significantly greater in patients with metastatic nodes than in patients without metastasis, whereas there was no significant correlation between the tumor volume and nodal metastasis in patients with oral cancer. Furthermore, the tumor volume significantly influenced the lymph node distribution in the neck of patients with pharyngeal cancer, but not in those with oral cancer. The tumor volume was a good indicator for the possible nodal metastasis in the neck of patients with oropharngeal or hypopharyngeal cancer, but not in those with oral cancer.

  • Research Products

    (2 results)

All 2005

All Journal Article (2 results)

  • [Journal Article] Volumetric MR Imaging of Oral, Maxillary Sinus, Oropharyngeal and Hypopharyngeal cancers : Correetion between Tumor Volume and Lymph Node Metastasis.2005

    • Author(s)
      Yasuo KIMURA, Misa SUMI, Yoko ICHIKAWA, Yosuke KAWAI, Takashi NAKAMURA
    • Journal Title

      AJNR American Journal of Neuroradiology 26・10

      Pages: 2384-2389

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Volumetric MR Imaging of Oral, Maxillary Sinus, Oropharyngeal, and Hypopharyngeal Cancers : Correlation between Tumor Volume and Lymph Node Metastasis.2005

    • Author(s)
      Kimura Y, Sumi M, Ichikawa Y, Kawai Y, Nakamura T.
    • Journal Title

      AJNR American Journal of Neuroradiolgy. 26(9)

      Pages: 2384-2389

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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