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2019 Fiscal Year Final Research Report

Study on physiological effects of isomalto-megalo-saccharides

Research Project

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Project/Area Number 17H01473
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionFuji Women's University (2018-2019)
Hokkaido University (2017)

Principal Investigator

Hara Hiroshi  藤女子大学, 人間生活学部, 教授 (70198894)

Co-Investigator(Kenkyū-buntansha) 比良 徹  北海道大学, 農学研究院, 講師 (10396301)
Project Period (FY) 2017-04-01 – 2020-03-31
Keywordsイソマルトメガロ糖 / 消化管バリア / 消化管ホルモン / ケルセチン
Outline of Final Research Achievements

Isomalto-megalo-saccharides are novel saccharides having unique structures. Various health promotive functions are expected due to their specific interactions with food components and with target cells in the gastrointestinal tract.
In an intestinal epithelial cell model (Caco2), isomalto-megalo-saccharides prevented impairment of gut barrier function by lipid oxidation products.In animal studies using rats, isomalto-megalo-saccharides enhanced intestinal absorption of quercetin. Furthermore, the combination of isomalto-megalo-saccharides and quercetin potently stimulated secretion of a gastrointestinal hormone, GLP-1.
These results demonstrate beneficial effects of isomalto-megalo-saccharides, as a functional food factor.

Free Research Field

食品栄養学

Academic Significance and Societal Importance of the Research Achievements

日本における糖質産業は、トレハロースや様々な難消化性オリゴ糖を開発し世界をリードしてきた。しかし、類似の技術によるオリゴ糖生産などが周辺国を中心に盛んになり、新たな技術による高機能な糖質の開発が強く求められている。申請課題は、糖質の持つ新たな可能性を拓くもので、日本の糖質産業が再び世界をリードする基盤的知見を提供できる。

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Published: 2021-02-19  

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