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2018 Fiscal Year Annual Research Report

Cancer vaccine therapy using peptide pulsed iPS derived DCs for pancreas cancer patients

Research Project

Project/Area Number 17H01580
Research InstitutionWakayama Medical University

Principal Investigator

山上 裕機  和歌山県立医科大学, 医学部, 教授 (20191190)

Co-Investigator(Kenkyū-buntansha) 北畑 裕司  和歌山県立医科大学, 医学部, 学内助教 (00535338)
清水 敦史  和歌山県立医科大学, 医学部, 博士研究員 (00637910)
川井 学  和歌山県立医科大学, 医学部, 准教授 (40398459)
岡田 健一  和歌山県立医科大学, 医学部, 講師 (50407988)
勝田 将裕  和歌山県立医科大学, 医学部, 准教授 (50464673)
尾島 敏康  和歌山県立医科大学, 医学部, 講師 (60448785)
廣野 誠子  和歌山県立医科大学, 医学部, 講師 (60468288)
宮澤 基樹  和歌山県立医科大学, 医学部, 助教 (90549734)
Project Period (FY) 2017-04-01 – 2021-03-31
KeywordsiPS細胞 / 樹状細胞 / 癌ワクチン
Outline of Annual Research Achievements

本研究「膵癌に対するiPS細胞由来樹状細胞による革新的ペプチドワクチン療法の臨床応用」は平成30年度は主に膵癌患者から誘導したiPS-DCにカクテルペプチドを刺激し,特異的CTLをin vitroで誘導する研究を施行した.
まずは,膵癌切除50例の組織におけるWT1, MUC-16, KIF20Aの抗原発現を解析した。さらに、手術を行った膵癌患者から得た癌細胞を、20%FCSでの希釈培養もしくはソフトアガー培地を使用し、コロニー形成を確認する。数回希釈培養し、膵癌細胞を株化を試みた。しかし,希釈培養での膵癌組織からのcell line化は困難であり,現在は3D培養を用いたCTOS法でのcell line化を行っている。CTOS法で得られた膵癌cell lineは免疫染色およびflow cytometryを用いて腫瘍関連抗原の発現を確認し,おのおのWT1 MUC-16 KIF20Aの発現を確認した。
その後エピソーマル・プラスミド法で誘導したiPS-DCの抗腫瘍効果の解析を行った.KIF20A, MUC16, Mesothelin, VEGFR1, R2をエピソーマル・プラスミド法で誘導したiPS-DCにパルスし、2日間培養した。ペプチド刺激後のDCの表面マーカーCD80, CD83, CD86, MHC-classI,classIIおよびCCR7, TLR2,4の発現確認を検討した。ついで、カクテルペプチドで刺激したiPS由来DCと同一患者から採取した末梢血単核球を混合培養し、ペプチド特異的なCTLを誘導を試みた。現在 in vitro CTL assayを行っている.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

今年度は主に膵癌患者から誘導したiPS-DCにカクテルペプチドを刺激し,特異的CTLをin vitroで誘導する研究を施行した.
最初に膵癌切除標本からのcell line化を培養希釈法で行ったが,繊維芽細胞の混入のため,cell line化は不可能であった。そのため、3D培養法を用いたCTOS法で腫瘍ライン化を行い,Assayの際に再度懸濁する方法に変更することで研究を遂行することが可能であった。現在はカクテルペプチド刺激iPS-DCを用いたin vitro CTLを誘導している.数回はCTLの誘導ができず,何度かプロトコールを変更し、現在はin vitro3回刺激でのCD8+CTLの誘導に成功している.
上記のごとく,何度かプロトコールを大きく変更したが,修正可能であり,おおむね研究は順調に進展していると自己評価を行った.

Strategy for Future Research Activity

今後は現在行っている膵癌患者から誘導したiPS-DCにカクテルペプチドを刺激し,特異的CTLをin vitroで誘導する研究をさらに続けていく.症例を増やし,CTOS法で得られたcell lineのTAA蛋白発現を確認し,順次得られたin vitro CTLとの殺細胞効果をCr release assayで行っていく.
また平成31年度はiPS-DCを用いたがんワクチン療法をclinical applicationするべく,前臨床試験を行う.具体的には①細胞表面マーカーの解析 ②無菌試験 ③エンドトキシン測定 ④マイコプラズマ否定試験 ⑤一般毒性試験 ⑥造腫瘍性試験・細胞増殖性試験を予定している.

  • Research Products

    (42 results)

All 2019 2018

All Journal Article (40 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 39 results,  Open Access: 14 results) Presentation (2 results)

  • [Journal Article] Robotic radical lymphadenectomy without touching the pancreas during gastrectomy for gastric cancer.2019

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Maruoka S, Yamaue H.
    • Journal Title

      Medicine

      Volume: 98 Pages: e15091

    • DOI

      10.1097/MD.0000000000015091.

    • Peer Reviewed / Open Access
  • [Journal Article] Decreased serum carbohydrate antigen 19-9 levels after neoadjuvant therapy predict a better prognosis for patients with pancreatic adenocarcinoma: a multicenter case-control study of 240 patients.2019

    • Author(s)
      Aoki S, Motoi F, Murakami Y, Sho M, Satoi S, Honda G, Uemura K, Okada KI, Matsumoto I, Nagai M, Yanagimoto H, Kurata M, Fukumoto T, Mizuma M, Yamaue H, Unno M; Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS).
    • Journal Title

      BMC Cancer.

      Volume: 19 Pages: 252

    • DOI

      10.1186/s12885-019-5460-4.

    • Peer Reviewed / Open Access
  • [Journal Article] Triplet chemotherapy with docetaxel, cisplatin and S-1 for unresectable advanced squamous cell carcinoma of the esophagus: phase I/II trial results.2019

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Oncotarget.

      Volume: 10 Pages: 847-855

    • DOI

      10.18632/oncotarget.26614.

    • Peer Reviewed / Open Access
  • [Journal Article] Triangulating stapling vs functional end-to-end stapling for cervical esophagogastric anastomosis after esophagectomy for thoracic esophageal cancer: study protocol for a randomized controlled trial.2019

    • Author(s)
      Tsuji T, Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Trials.

      Volume: 20 Pages: 83

    • DOI

      10.1186/s13063-019-3201-2.

    • Peer Reviewed / Open Access
  • [Journal Article] Concomitant Use of Indocyanine Green Fluorescence Imaging and Interventional Radiology for Detection of Liver Segments During Laparoscopic Anatomical Liver Resection: Pilot Feasibility Study.2019

    • Author(s)
      Ueno M, Hayami S, Sonomura T, Kawai M, Hirono S, Okada KI, Tanaka R, Yamaue H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: in press Pages: in press

    • DOI

      10.1097/SLE.0000000000000631.

    • Peer Reviewed
  • [Journal Article] Clinical Impact of Neoadjuvant Chemotherapy and Chemoradiotherapy in Borderline Resectable Pancreatic Cancer: Analysis of 884 Patients at Facilities Specializing in Pancreatic Surgery.2019

    • Author(s)
      Nagakawa Y, Sahara Y, Hosokawa Y, Murakami Y, Yamaue H, Satoi S, Unno M, Isaji S, Endo I, Sho M, Fujii T, Takishita C, Hijikata Y, Suzuki S, Kawachi S, Katsumata K, Ohta T, Nagakawa T, Tsuchida A.
    • Journal Title

      Ann Surg Oncol.

      Volume: in press Pages: in press

    • DOI

      10.1245/s10434-018-07131-8.

    • Peer Reviewed
  • [Journal Article] Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05).2019

    • Author(s)
      Motoi F, Kosuge T, Ueno H, Yamaue H, Satoi S, Sho M, Honda G, Matsumoto I, Wada K, Furuse J, Matsuyama Y, Unno M; Study Group of Preoperative Therapy for Pancreatic Cancer (Prep) and Japanese Study Group of Adjuvant Therapy for Pancreatic cancer (JSAP).
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 49 Pages: 190-194.

    • DOI

      10.1093/jjco/hyy190.

    • Peer Reviewed
  • [Journal Article] Robotic complete lymphadenectomy at the splenic hilum during total gastrectomy for advanced gastric cancer (with video).2019

    • Author(s)
      Ojima T, Hayata K, Yamaue H.
    • Journal Title

      J Visc Surg.

      Volume: in press Pages: in press

    • DOI

      10.1016/j.jviscsurg.2018.12.005.

    • Peer Reviewed
  • [Journal Article] Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment.2019

    • Author(s)
      Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 68 Pages: 201-211

    • DOI

      10.1007/s00262-018-2263-4.

    • Peer Reviewed
  • [Journal Article] Sustained Elevation of Postoperative Serum Level of Carbohydrate Antigen 19-9 is High-Risk Stigmata for Primary Hepatic Recurrence in Patients with Curatively Resected Pancreatic Adenocarcinoma.2019

    • Author(s)
      Motoi F, Murakami Y, Okada KI, Matsumoto I, Uemura K, Satoi S, Sho M, Honda G, Fukumoto T, Yanagimoto H, Kinoshita S, Kurata M, Aoki S, Mizuma M, Yamaue H, Unno M; Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS).
    • Journal Title

      World J Surg.

      Volume: 43 Pages: 634-641.

    • DOI

      10.1007/s00268-018-4814-4.

    • Peer Reviewed
  • [Journal Article] Conversion Surgery for Gastric Cancer with Peritoneal Metastasis Based on the Diagnosis of Second-Look Staging Laparoscopy.2019

    • Author(s)
      Nakamura M, Ojima T, Nakamori M, Katsuda M, Tsuji T, Hayata K, Kato T, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: in press Pages: in press

    • DOI

      10.1007/s11605-018-3983-7.

    • Peer Reviewed
  • [Journal Article] Optimal Timing of Removal of Epidural and Urethral Catheters to Avoid Postoperative Urinary Retention Undergoing Abdominal Surgery.2019

    • Author(s)
      Hayami S, Ueno M, Kawai M, Kuriyama T, Kawamata T, Yamaue H.
    • Journal Title

      Dig Surg.

      Volume: 36 Pages: 261-265.

    • DOI

      10.1159/000490199.

    • Peer Reviewed
  • [Journal Article] Modified Blumgart Mattress Suture Versus Conventional Interrupted Suture in Pancreaticojejunostomy During Pancreaticoduodenectomy: Randomized Controlled Trial.2019

    • Author(s)
      Hirono S, Kawai M, Okada KI, Miyazawa M, Kitahata Y, Hayami S, Ueno M, Yamaue H.
    • Journal Title

      Ann Surg.

      Volume: 269 Pages: 243-251.

    • DOI

      0.1097/SLA.0000000000002802.

    • Peer Reviewed
  • [Journal Article] MAPLE-PD trial (Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer during Pancreaticoduodenectomy): study protocol for a multicenter randomized controlled trial of 354 patients with pancreatic ductal adenocarcinoma.2018

    • Author(s)
      Hirono S, Kawai M, Okada KI, Fujii T, Sho M, Satoi S, Amano R, Eguchi H, Mataki Y, Nakamura M, Matsumoto I, Baba H, Tani M, Kawabata Y, Nagakawa Y, Yamada S, Murakami Y, Shimokawa T, Yamaue H.
    • Journal Title

      Trials.

      Volume: 19 Pages: 613

    • DOI

      10.1186/s13063-018-3002-z.

    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma.2018

    • Author(s)
      Shigekawa Y, Hayami S, Ueno M, Miyamoto A, Suzaki N, Kawai M, Hirono S, Okada KI, Hamamoto R, Yamaue H.
    • Journal Title

      Oncotarget

      Volume: 9 Pages: 34320-34335.

    • DOI

      10.18632/oncotarget.26144. e

    • Peer Reviewed / Open Access
  • [Journal Article] Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN-PD.2018

    • Author(s)
      Maeda H, Okada KI, Fujii T, Oba MS, Kawai M, Hirono S, Kodera Y, Sho M, Akahori T, Shimizu Y, Ambo Y, Kondo N, Murakami Y, Ohuchida J, Eguchi H, Nagano H, Sakamoto J, Yamaue H.
    • Journal Title

      Oncol Lett.

      Volume: 16 Pages: 6847-6853.

    • DOI

      10.3892/ol.2018.9422.

    • Peer Reviewed
  • [Journal Article] Outcomes of 1,639 hepatectomies for non-colorectal non-neuroendocrine liver metastases: a multicenter analysis.2018

    • Author(s)
      Sano K, Yamamoto M, Mimura T, Endo I, Nakamori S, Konishi M, Miyazaki M, Wakai T, Nagino M, Kubota K, Unno M, Sata N, Yamamoto J, Yamaue H, Takada T; Japanese Society of Hepato-Biliary-Pancreatic Surgery.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 465-475.

    • DOI

      10.1002/jhbp.587.

    • Peer Reviewed
  • [Journal Article] Learning curve and surgical factors influencing the surgical outcomes during the initial experience with laparoscopic pancreaticoduodenectomy.2018

    • Author(s)
      Nagakawa Y, Nakamura Y, Honda G, Gotoh Y, Ohtsuka T, Ban D, Nakata K, Sahara Y, Velasquez VVDM, Takaori K, Misawa T, Kuroki T, Kawai M, Morikawa T, Yamaue H, Tanabe M, Mou Y, Lee WJ, Shrikhande SV, Conrad C, Han HS, Tang CN, Palanivelu C, Kooby DA, Asbun HJ, Wakabayashi G, Tsuchida A, Takada T, Yamamoto M, Nakamura M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 498-507.

    • DOI

      10.1002/jhbp.586.

    • Peer Reviewed
  • [Journal Article] Intensive perioperative rehabilitation improves surgical outcomes after pancreaticoduodenectomy.2018

    • Author(s)
      Kitahata Y, Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kobayashi R, Ueno M, Hayami S, Shimokawa T, Kouda K, Tajima F, Yamaue H.
    • Journal Title

      Langenbecks Arch Surg.

      Volume: 403 Pages: 711-718.

    • DOI

      10.1007/s00423-018-1710-1.

  • [Journal Article] Endoscopic treatment of esophageal fistulas after esophagectomy with injection of an alpha-cyanoacrylate monomer: a phase II study.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Tsuji T, Maruoka S, Yamaue H.
    • Journal Title

      Endosc Int Open.

      Volume: 6 Pages: E1093-E1099.

    • DOI

      10.1055/a-0581-9005.

    • Peer Reviewed / Open Access
  • [Journal Article] Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and S-1 for Resectable Advanced Esophageal Cancer.2018

    • Author(s)
      Hayata K, Ojima T, Nakamori M, Nakamura M, Katsuda M, Kitadani J, Takeuchi A, Tabata H, Maruoka S, Yamaue H.
    • Journal Title

      Anticancer Res.

      Volume: 38 Pages: 5267-5273.

    • DOI

      10.21873/anticanres.12852.

    • Peer Reviewed
  • [Journal Article] Reinforced Stapling Technique for Reconstruction After Laparoscopic Distal Gastrectomy.2018

    • Author(s)
      Ojima T, Nakamura M, Hayata K, Nakamori M, Yamaue H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: 28 Pages: 334-336.

    • DOI

      10.1097/SLE.0000000000000570.

    • Peer Reviewed
  • [Journal Article] Correction: Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.2018

    • Author(s)
      Furuta M, Tanaka H, Shiraishi Y, Uchida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H.
    • Journal Title

      Oncotarget.

      Volume: 9 Pages: 31789

    • DOI

      10.18632/oncotarget.25960.

    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a novel HLA-A24-restricted cytotoxic T lymphocyte epitope peptide derived from mesothelin in pancreatic cancer.2018

    • Author(s)
      Tsukagoshi M, Wada S, Hirono S, Yoshida S, Yada E, Sasada T, Shirabe K, Kuwano H, Yamaue H.
    • Journal Title

      Oncotarget.

      Volume: 9 Pages: 31448-31458.

    • DOI

      10.18632/oncotarget.25837.

    • Peer Reviewed / Open Access
  • [Journal Article] Difficulty scoring system in laparoscopic distal pancreatectomy.2018

    • Author(s)
      Ohtsuka T, Ban D, Nakamura Y, Nagakawa Y, Tanabe M, Gotoh Y, Velasquez VVDM, Nakata K, Sahara Y, Takaori K, Honda G, Misawa T, Kawai M, Yamaue H, Morikawa T, Kuroki T, Mou Y, Lee WJ, Shrikhande SV, Tang CN, Conrad C, Han HS, Palanivelu C, Asbun HJ, Kooby DA, Wakabayashi G, Takada T, Yamamoto M, Nakamura M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 489-497.

    • DOI

      10.1002/jhbp.578.

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It.2018

    • Author(s)
      Klompmaker S, Boggi U, Hackert T, Salvia R, Weiss M, Yamaue H, Zeh HJ, Besselink MG.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 1804-1810.

    • DOI

      10.1007/s11605-018-3894-7.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Significance of hepatic resection and adjuvant hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombus in the first branch of portal vein and the main portal trunk: a project study for hepatic surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery.2018

    • Author(s)
      Hatano E, Uemoto S, Yamaue H, Yamamoto M; Japanese Society of Hepato-Biliary-Pancreatic Surgery.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 395-402.

    • DOI

      10.1002/jhbp.574.

    • Peer Reviewed
  • [Journal Article] Resection for recurrent pancreatic cancer in the remnant pancreas after pancreatectomy is clinically promising: Results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.2018

    • Author(s)
      Yamada S, Kobayashi A, Nakamori S, Baba H, Yamamoto M, Yamaue H, Fujii T.
    • Journal Title

      Surgery.

      Volume: 164 Pages: 1049-1056.

    • DOI

      10.1016/j.surg.2018.05.050.

    • Peer Reviewed
  • [Journal Article] Robotic versus laparoscopic gastrectomy with lymph node dissection for gastric cancer: study protocol for a randomized controlled trial.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Trials.

      Volume: 19 Pages: 409

    • DOI

      10.1186/s13063-018-2810-5.

    • Peer Reviewed / Open Access
  • [Journal Article] Ischemic gastropathy after distal pancreatectomy with en bloc celiac axis resection for pancreatic body cancer.2018

    • Author(s)
      Okada KI, Kawai M, Hirono S, Miyazawa M, Kitahata Y, Ueno M, Hayami S, Shimokawa T, Yamaue H.
    • Journal Title

      Langenbecks Arch Surg.

      Volume: 403 Pages: 561-571

    • DOI

      10.1007/s00423-018-1692-z.

    • Peer Reviewed
  • [Journal Article] Clinical impact of developing better practices at the institutional level on surgical outcomes after distal pancreatectomy in 1515 patients: Domestic audit of the Japanese Society of Pancreatic Surgery.2018

    • Author(s)
      Satoi S, Yamamoto T, Motoi F, Matsumoto I, Yoshitomi H, Amano R, Tahara M, Murakami Y, Arimitsu H, Hirono S, Sho M, Ryota H, Ohtsuka M, Unno M, Takeyama Y, Yamaue H.
    • Journal Title

      Ann Gastroenterol Surg.

      Volume: 25 Pages: 212-219.

    • DOI

      10.1002/ags3.12066.

    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.2018

    • Author(s)
      Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H.
    • Journal Title

      Oncotarget.

      Volume: 9 Pages: 25075-25088.

    • DOI

      10.18632/oncotarget.25308.

    • Peer Reviewed / Open Access
  • [Journal Article] Phase I/II Trial of Chemotherapy with Docetaxel, Cisplatin, and S-1 for Unresectable Advanced Squamous Cell Carcinoma of the Esophagus.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Oncology.

      Volume: 95 Pages: 116-120.

    • DOI

      10.1159/000488861.

    • Peer Reviewed
  • [Journal Article] Fundoplication with 180-Degree Wrap During Esophagogastrostomy After Robotic Proximal Gastrectomy for Early Gastric Cancer.2018

    • Author(s)
      Ojima T, Nakamori M, Nakamura M, Hayata K, Maruoka S, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 1475-1476.

    • DOI

      10.1007/s11605-018-3765-2.

    • Peer Reviewed
  • [Journal Article] Artery-first approach for pancreaticoduodenectomy.2018

    • Author(s)
      Kawai M, Hirano S, Yamaue H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 319-320.

    • DOI

      10.1002/jhbp.554.

    • Peer Reviewed
  • [Journal Article] A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer.2018

    • Author(s)
      Sundar R, Rha SY, Yamaue H, Katsuda M, Kono K, Kim HS, Kim C, Mimura K, Kua LF, Yong WP.
    • Journal Title

      BMC Cancer.

      Volume: 18 Pages: 332.

    • DOI

      10.1186/s12885-018-4234-8.

    • Peer Reviewed / Open Access
  • [Journal Article] Pelvic Drain After Laparoscopic Low Anterior Resection for Rectal Cancer in Patients With Diverting Stoma.2018

    • Author(s)
      Matsuda K, Yokoyama S, Hotta T, Watanabe T, Tamura K, Iwamoto H, Mizumoto Y, Yamaue H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: 28 Pages: 82-85.

    • DOI

      10.1097/SLE.0000000000000517.

    • Peer Reviewed
  • [Journal Article] Cancer Vaccine Therapy Using Carcinoembryonic Antigen - expressing Dendritic Cells generated from Induced Pluripotent Stem Cells.2018

    • Author(s)
      Kitadani J, Ojima T, Iwamoto H, Tabata H, Nakamori M, Nakamura M, Hayata K, Katsuda M, Miyajima M, Yamaue H.
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 4569.

    • DOI

      10.1038/s41598-018-23120-z.

    • Peer Reviewed
  • [Journal Article] Laparoscopic and Endoscopic Cooperative Surgery Versus Endoscopic Submucosal Dissection for the Treatment of Low-Risk Tumors of the Duodenum.2018

    • Author(s)
      Ojima T, Nakamori M, Nakamura M, Hayata K, Katsuda M, Takifuji K, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 935-940.

    • DOI

      10.1007/s11605-018-3680-6.

    • Peer Reviewed
  • [Journal Article] Prevention of Internal Hernia During Robotic Total Gastrectomy for Gastric Cancer.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Tsuji T, Maruoka S, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 934.

    • DOI

      10.1007/s11605-018-3678-0.

    • Peer Reviewed
  • [Presentation] iPS細胞由来樹状細胞を用いたテーラーメード癌ワクチン療法の現状と未来2018

    • Author(s)
      尾島敏康 岩本博光 北谷純也 田端宏尭 出口真彰 中森幹人 中村公紀 勝田将裕 早田啓治 丸岡慎平 山上裕機
    • Organizer
      第31回日本バイオセラピー学会学術集会
  • [Presentation] Cancer vaccine therapy using iPS-derived dendritic cells Second Department of Surgery, Wakayama medical university, school of medicine2018

    • Author(s)
      尾島敏康 岩本博光 北谷純也 田端宏尭 出口真彰 中森幹人 中村公紀 勝田将裕 早田啓治 丸岡慎平 山上裕機
    • Organizer
      第56回日本癌治療学会学術集会

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Published: 2019-12-27  

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