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2018 Fiscal Year Annual Research Report

Comprehensive study on fat accumulation in skeletal muscle

Research Project

Project/Area Number 17H04153
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

荒井 秀典  国立研究開発法人国立長寿医療研究センター, 病院, 理事長 (60232021)

Co-Investigator(Kenkyū-buntansha) 山田 実  筑波大学, 人間系, 教授 (30525572)
松井 康素  国立研究開発法人国立長寿医療研究センター, ロコモフレイルセンター, 部長 (50501623)
佐竹 昭介  国立研究開発法人国立長寿医療研究センター, その他部局等, その他 (50508116)
Project Period (FY) 2017-04-01 – 2020-03-31
Keywords老年医学 / サルコペニア
Outline of Annual Research Achievements

H30年度は、超音波画像により推定した骨格筋内脂肪(IMAT)と関連するバイオマーカーを検証した。H29年度の調査により、骨格筋の超音波画像のエコー輝度より得られた値は種々の骨格筋指標と関連しており、IMATを反映する指標として有用であると考えられた。本研究では、この超音波画像より推定したIMATと関連するバイオマーカーを探索することである。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究の対象は、地域在住高齢者367名であった。対象者には、大腿前面部の超音波画像を計測し、IMATの指標となるエコー輝度を算出した。また、採血を行い、過去の研究で骨格筋との関連性が示されている、インスリン様成長因子(IGF-1)、デヒドロエピアンドロステロン(DHEA)、25(OH)D、TNF-α、アディポネクチン、酸化LDL、過酸化脂質の血中濃度を算出した。
分析対象は、男性114名(80.6±7.4歳)、女性253名(80.5±6.8歳)であり、男女それぞれで分析を行った。男性のIMATと関連性を認めたのは、IGF-1、DHEA、TNF-α、アディポネクチン、過酸化脂質であり、女性のIMATと関連性を認めたのは、IGF-1、25(OH)D、アディポネクチン、過酸化脂質であった。なお、いずれも弱い相関関係に留まった。
男女ともにIMATと関連が認められたのは、IGF-1、アディポネクチン、過酸化脂質であった。これらはバイオマーカーとして有用であるとともに、IMATの抑制を検討した際に、極めて重要な要因となる可能性が示された。

Strategy for Future Research Activity

今後は、介入にてIMATの抑制が可能となるのかを検証することで、サルコペニアやダイナペニア高齢者の対策に活かしていく必要がある。

  • Research Products

    (22 results)

All 2019 2018

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (8 results) (of which Int'l Joint Research: 8 results,  Invited: 5 results)

  • [Journal Article] Daily physical activity predicts frailty development among community-dwelling older Japanese adults.2019

    • Author(s)
      1.Yuki A, Otsuka R, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H, Arai H.
    • Journal Title

      J Am Med Dir Assoc

      Volume: - Pages: -

    • DOI

      10.1016/j.jamda.2019.01.001.

    • Peer Reviewed / Open Access
  • [Journal Article] Predictive ability of seven domains of the Kihon Checklist for incident dependency and mortality.2019

    • Author(s)
      Satake S, Shimokata H, Senda K, Kondo I, Arai H, Toba K.
    • Journal Title

      J Frailty Aging

      Volume: 8 Pages: 85-87

    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive Frailty in Geriatrics2018

    • Author(s)
      Arai Hidenori、Satake Shosuke、Kozaki Koichi
    • Journal Title

      Clinics in Geriatric Medicine

      Volume: 34 Pages: 667~675

    • DOI

      10.1016/j.cger.2018.06.011

    • Peer Reviewed / Open Access
  • [Journal Article] Social frailty predicts incident disability and mortality among community-dwelling Japanese older adults2018

    • Author(s)
      Yamada M, Arai H.
    • Journal Title

      J Am Med Dir Assoc

      Volume: 19 Pages: 1099-1103

    • Peer Reviewed
  • [Journal Article] Cognitive Frailty Predicts Incident Dementia among Community-Dwelling Older People2018

    • Author(s)
      Shimada Hiroyuki、Doi Takehiko、Lee Sangyoon、Makizako Hyuma、Chen Liang-Kung、Arai Hidenori
    • Journal Title

      Journal of Clinical Medicine

      Volume: 7 Pages: 250~250

    • DOI

      10.3390/jcm7090250

    • Peer Reviewed
  • [Journal Article] Development of the Dementia Assessment Sheet for Community-based Integrated Care System 8-items, a short version of the Dementia Assessment Sheet for Community-based Integrated Care System 21-items, for the assessment of cognitive and daily functions2018

    • Author(s)
      Toyoshima Kenji、Araki Atsushi、Tamura Yoshiaki、Iritani Osamu、Ogawa Sumito、Kozaki Koichi、Ebihara Satoru、Hanyu Haruo、Arai Hiroyuki、Kuzuya Masafumi、Iijima Katsuya、Sakurai Takashi、Suzuki Takao、Toba Kenji、Arai Hidenori、Akishita Masahiro、Rakugi Hiromi、Yokote Koutaro、Ito Hideki、Awata Shuichi
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 18 Pages: 1458~1462

    • DOI

      10.1111/ggi.13512

    • Peer Reviewed
  • [Journal Article] Effect of a Positive Photo Appreciation Program on Depressive Mood in Older Adults: A Pilot Randomized Controlled Trial2018

    • Author(s)
      Ishihara M, Saito T, Sakurai T, Shimada H, Arai H.
    • Journal Title

      Int J Environ Res Public Health

      Volume: 12 Pages: 15

    • Peer Reviewed / Open Access
  • [Journal Article] Oral function as an indexing parameter for mild cognitive impairment in older adults.2018

    • Author(s)
      Watanabe Y, Arai H, Hirano H, Morishita S, Ohara Y, Edahiro A, Murakami M, Shimada H, Kikutani T, Suzuki T.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 18 Pages: 790~798

    • Peer Reviewed / Open Access
  • [Journal Article] Factors affecting the appetites of persons with Alzheimer's disease and mild cognitive impairment2018

    • Author(s)
      Suma Shino、Watanabe Yutaka、Hirano Hirohiko、Kimura Ai、Edahiro Ayako、Awata Shuichi、Yamashita Yoshihisa、Matsushita Kenji、Arai Hidenori、Sakurai Takashi
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 18 Pages: 1236~1243

    • DOI

      10.1111/ggi.13455

    • Peer Reviewed / Open Access
  • [Journal Article] Involving Primary Care Health Professionals in Geriatric Assessment2018

    • Author(s)
      Foug?re B.、Cesari M.、Arai H.、Woo J.、Merchant R. A.、Flicker L.、Cherubini A.、Bauer J. M.、Vellas B.、Morley J. E.
    • Journal Title

      The journal of nutrition, health & aging

      Volume: 22 Pages: 566~568

    • DOI

      10.1007/s12603-018-1001-0

    • Peer Reviewed
  • [Journal Article] Community activities predict disability and mortality in community-dwelling older adults2018

    • Author(s)
      Okura Mika、Ogita Mihoko、Yamamoto Miki、Nakai Toshimi、Numata Tomoko、Arai Hidenori
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 18 Pages: 1114~1124

    • DOI

      10.1111/ggi.13315

    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiological and clinical significance of cognitive frailty: A mini review2018

    • Author(s)
      Sugimoto Taiki、Sakurai Takashi、Ono Rei、Kimura Ai、Saji Naoki、Niida Shumpei、Toba Kenji、Chen Liang-Kung、Arai Hidenori
    • Journal Title

      Ageing Research Reviews

      Volume: 44 Pages: 1~7

    • DOI

      10.1016/j.arr.2018.03.002

    • Peer Reviewed / Open Access
  • [Journal Article] What is the best adjustment of appendicular lean mass for predicting mortality or disability among Japanese community dwellers?2018

    • Author(s)
      Otsuka Rei、Matsui Yasumoto、Tange Chikako、Nishita Yukiko、Tomida Makiko、Ando Fujiko、Shimokata Hiroshi、Arai Hidenori
    • Journal Title

      BMC Geriatrics

      Volume: 18 Pages: -

    • DOI

      10.1186/s12877-017-0699-6

    • Peer Reviewed / Open Access
  • [Journal Article] Oral function as an indexing parameter for mild cognitive impairment in older adults2018

    • Author(s)
      Watanabe Yutaka、Arai Hidenori、Hirano Hirohiko、Morishita Shiho、Ohara Yuki、Edahiro Ayako、Murakami Masaharu、Shimada Hiroyuki、Kikutani Takeshi、Suzuki Takao
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 18 Pages: 790~798

    • DOI

      10.1111/ggi.13259

    • Peer Reviewed / Open Access
  • [Presentation] Social Frailty predicts incident disability and mortality among community-dwelling Japanese older adults2018

    • Author(s)
      Arai H
    • Organizer
      he 11th National Conference on the Prevention and Management of Common Diseases in the Elderly & The 4th Asian Conference for Frailty and Sarcopenia
    • Int'l Joint Research / Invited
  • [Presentation] Aged care in Japan: Past, current and future2018

    • Author(s)
      Arai H
    • Organizer
      International Symposium of Aged Health and Care
    • Int'l Joint Research / Invited
  • [Presentation] Formula for Longevity: the Japanese's Secrets of Success2018

    • Author(s)
      Arai H
    • Organizer
      13th International Symposium on Healthy Aging
    • Int'l Joint Research / Invited
  • [Presentation] New advance in prevention for disability and dementia2018

    • Author(s)
      Arai H
    • Organizer
      2018 Taiwan PMR annual meeting
    • Int'l Joint Research / Invited
  • [Presentation] Association between frailty and micronutrients insufficiency in Japanese older outpatients2018

    • Author(s)
      Kinoshita K, Satake S, Matsui Y, Arai H
    • Organizer
      ICFSR 2018
    • Int'l Joint Research
  • [Presentation] Implementation, of an integrated healthy aging clinic to investigate frailty, sarcopenia, and, locomotive syndrome in a clinical setting2018

    • Author(s)
      Matsui M, Arai H, Watanabe Y, Satake S, Senda, Kondo I, Kinoshita K, Ito N, Sabre SM, Harada A
    • Organizer
      ICFSR 2018
    • Int'l Joint Research
  • [Presentation] Cognitive frailty: from conceptual proposal to clinical practice2018

    • Author(s)
      Chen LK, Shimada H, Peng LN, Liang CK, Arai H
    • Organizer
      ICFSR 2018
    • Int'l Joint Research
  • [Presentation] Sarcopenia and Frailty guidelines update in Asia2018

    • Author(s)
      Arai H
    • Organizer
      ICFSR 2018
    • Int'l Joint Research / Invited

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Published: 2019-12-27  

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