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2019 Fiscal Year Annual Research Report

Comprehensive study on fat accumulation in skeletal muscle

Research Project

Project/Area Number 17H04153
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

荒井 秀典  国立研究開発法人国立長寿医療研究センター, 理事長 (60232021)

Co-Investigator(Kenkyū-buntansha) 山田 実  筑波大学, 人間系, 教授 (30525572)
松井 康素  国立研究開発法人国立長寿医療研究センター, ロコモフレイルセンター, 部長 (50501623)
佐竹 昭介  国立研究開発法人国立長寿医療研究センター, 病院, 部長 (50508116)
Project Period (FY) 2017-04-01 – 2020-03-31
Keywords老年医学 / サルコペニア
Outline of Annual Research Achievements

本研究の目的は、電気刺激(EMS)とたんぱく質摂取の併用療法による骨格筋機能向上効果を検証するため、12週間の介入期間を設け、EMSと栄養補助(EMS+N)、EMS単独(EMS)、栄養補助単独(N)、コントロール(Control)の4群において、筋肉内脂肪(IMAT)およびその他骨格筋機能、身体機能への効果を検証した。175名の候補者の中から包含基準を満たした88名(81.8±5.3歳、女性55名)を対象とし、介入前後の変化量の4群比較を実施したところ、筋質および大腿直筋のエコー輝度に有意差を認め、いずれもEMS+N群で良好な改善を認めた。EMS+NにはIMATを抑制し、骨格筋の質を改善させる効果が示された。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

  • Research Products

    (23 results)

All 2020 2019

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (15 results) (of which Int'l Joint Research: 4 results,  Invited: 11 results)

  • [Journal Article] Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment2020

    • Author(s)
      Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T,Akishita M, Arai H
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 21 Pages: 300~307.e2

    • DOI

      https://doi.org/10.1016/j.jamda.2019.12.012

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive geriatric intervention in community‐dwelling older adults: a cluster‐randomized controlled trial2020

    • Author(s)
      Watanabe Yuya、Yamada Yosuke、Yoshida Tsukasa、Yokoyama Keiichi、Miyake Motoko、Yamagata Emi、Yamada Minoru、Yoshinaka Yasuko、Kimura Misaka、for Kyoto‐Kameoka Study Group
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 11 Pages: 26~37

    • DOI

      10.1002/jcsm.12504

    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between tongue muscle quality and swallowing speed in community-dwelling older women.2019

    • Author(s)
      Suzuki M, Koyama S, Kimura Y, Ishiyama D, Ohji S, Otobe Y, Nishio N, Kunieda Y, Ichikawa T, Ito D, Ogawa H, Yamada M.
    • Journal Title

      Aging Clin Exp Res.

      Volume: - Pages: -

    • Peer Reviewed
  • [Journal Article] Development and validation of Comprehensive Gait Assessment using InerTial Sensor score (C-GAITS score) derived from acceleration and angular velocity data at heel and lower trunk among community-dwelling older adults2019

    • Author(s)
      Misu Shogo、Asai Tsuyoshi、Doi Takehiko、Sawa Ryuichi、Ueda Yuya、Murata Shunsuke、Saito Takashi、Sugimoto Taiki、Isa Tsunenori、Tsuboi Yamato、Yamada Minoru、Ono Rei
    • Journal Title

      Journal of NeuroEngineering and Rehabilitation

      Volume: 16 Pages: 62

    • DOI

      10.1186/s12984-019-0539-3

    • Peer Reviewed / Open Access
  • [Journal Article] Presence of sarcopenic obesity and evaluation of the associated muscle quality in Japanese older men with prostate cancer undergoing androgen deprivation therapy2019

    • Author(s)
      Kimura Yosuke、Yamada Minoru、Ohji Shunsuke、Ishiyama Daisuke、Nishio Naohito、Otobe Yuhei、Koyama Shingo、Suzuki Mizue、Ichikawa Takeo、Ito Daisuke、Maehori Naomi、Nagae Hiroshi
    • Journal Title

      Journal of Geriatric Oncology

      Volume: 10 Pages: 835~838

    • DOI

      10.1016/j.jgo.2019.03.017

    • Peer Reviewed / Open Access
  • [Journal Article] Measurement of self-propulsion distance of wheelchair using cycle computer excluding assistance distance by touch switch: A pilot study2019

    • Author(s)
      Ohji Shunsuke、Kimura Yosuke、Otobe Yuhei、Nishio Naohito、Ito Daisuke、Taguchi Ryota、Ogawa Hideyuki、Yamada Minoru
    • Journal Title

      The Journal of Spinal Cord Medicine

      Volume: 11 Pages: 1~5

    • DOI

      10.1080/10790268.2019.1601936

    • Peer Reviewed / Open Access
  • [Journal Article] Association of bioimpedance phase angle and prospective falls in older adults2019

    • Author(s)
      Uemura Kazuki、Yamada Minoru、Okamoto Hiroshi
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 19 Pages: 503~507

    • DOI

      10.1111/ggi.13651

    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic effect of bodyweight resistance exercise and protein supplementation on skeletal muscle in sarcopenic or dynapenic older adults2019

    • Author(s)
      Yamada Minoru、Kimura Yosuke、Ishiyama Daisuke、Nishio Naohito、Otobe Yuhei、Tanaka Tomoya、Ohji Shunsuke、Koyama Shingo、Sato Atsushi、Suzuki Mizue、Ogawa Hideyuki、Ichikawa Takeo、Ito Daisuke、Arai Hidenori
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 19 Pages: 429~437

    • DOI

      10.1111/ggi.13643

    • Peer Reviewed / Open Access
  • [Presentation] Long term care insurance system in Japan2019

    • Author(s)
      Arai H
    • Organizer
      The 11th International Association of Gerontology and Geriatrics Asia/Oceania Regional Congress
    • Int'l Joint Research
  • [Presentation] Clinical impact and underlying mechanisms of frailty & sarcopenia among memory clinic populations2019

    • Author(s)
      Sugimoto T, Sakurai T, Arai H
    • Organizer
      5th ASIAN CONFERENCE for FRAILTY AND SARCOPENIA
    • Int'l Joint Research
  • [Presentation] Asian Perspectives for Sarcopenia: AWGS 2019 Revised Consensus for Sarcopenia Diagnosis and Treatment2019

    • Author(s)
      Chen LK, Arai H, Woo J
    • Organizer
      5th ASIAN CONFERENCE for FRAILTY AND SARCOPENIA
    • Int'l Joint Research
  • [Presentation] Aged care in Japan: Past, current and future2019

    • Author(s)
      Arai H
    • Organizer
      Asia-Pacific Forum for Long-term Care in Aging
    • Int'l Joint Research
  • [Presentation] AWGS2019でサルコペニアの診断はどう変わったのか?2019

    • Author(s)
      荒井 秀典
    • Organizer
      第23回日本病態栄養学会年次学術集会
    • Invited
  • [Presentation] サルコペニアの診断update2019

    • Author(s)
      荒井 秀典
    • Organizer
      第34回日本臨床リウマチ学会
    • Invited
  • [Presentation] サルコペニア・フレイルの最新知見2019

    • Author(s)
      荒井 秀典
    • Organizer
      第12回運動器疼痛学会
    • Invited
  • [Presentation] アジアのサルコペニアに診断基準:どう変わるのか?2019

    • Author(s)
      荒井 秀典
    • Organizer
      第41回日本臨床栄養学会総会・第40回日本臨床栄養協会総会
    • Invited
  • [Presentation] 認知症予防のためのフレイル対策~認知的フレイルとは~2019

    • Author(s)
      荒井 秀典
    • Organizer
      第9回日本認知症予防学会学術集会
    • Invited
  • [Presentation] 超高齢社会の周術期看護を考える-フレイル、サルコペニア対策を中心に-2019

    • Author(s)
      荒井 秀典
    • Organizer
      日本看護手術学会第33回年次大会
    • Invited
  • [Presentation] 高齢糖尿病患者の各種併発症2019

    • Author(s)
      荒井 秀典
    • Organizer
      第34回日本糖尿病合併症学会
    • Invited
  • [Presentation] 健康長寿をめざして~高齢者に対する健診のありかた~2019

    • Author(s)
      荒井 秀典
    • Organizer
      第60回日本人間ドック学会学術大会
    • Invited
  • [Presentation] 外科治療におけるサルコペニア・フレイルの意義を考える2019

    • Author(s)
      荒井 秀典
    • Organizer
      第44回日本外科系連合学会学術集会
    • Invited
  • [Presentation] 老年医学から高齢者への適切な対応を学ぶ2019

    • Author(s)
      荒井 秀典
    • Organizer
      第118回日本皮膚科学会総会
    • Invited
  • [Presentation] サルコペニアの概念・意義・展望2019

    • Author(s)
      荒井 秀典
    • Organizer
      第30回日本医学会総会
    • Invited

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Published: 2021-01-27  

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