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2019 Fiscal Year Final Research Report

Role of myokines and AMPK in skeletal muscle in streptozotocin-induced diabetec mice

Research Project

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Project/Area Number 17H04203
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

Minokoshi Yasuhiko  生理学研究所, 生体機能調節研究領域, 教授 (10200099)

Project Period (FY) 2017-04-01 – 2020-03-31
KeywordsAMPK / ストレプトゾトシン糖尿病 / 骨格筋 / マイオカイン
Outline of Final Research Achievements

AMP kinase (AMPK), a metabolic sensor that is activated by energy deficiency, plays an important role in the control of energy metabolism. We found that mice expressing dominant negative AMPK (DN-AMPK Tg) in skeletal muscle dramatically imporve metabolic abonormalities such as hyperglycemia, hyperlipidemia and high fatty acids levels of streptozotocin-treated diabeteci miceand extended the survival rate. Studies with recombinat proteins and neutral antibodies for myokines including IL-6 and myonectin revealed that the effects of DN-AMPK Tg in skeletal muscle on STZ diabetes are associated with changes in plasma myokine levles secreted from skeletal muscle.

Free Research Field

代謝・内分泌学

Academic Significance and Societal Importance of the Research Achievements

本研究では、STZ糖尿病の代謝異常の一部が、インスリン欠乏だけでなく、骨格筋を始めとする臓器間相互ネットワーク異常に起因するとの考えに立ち、骨格筋選択的にAMPK活性を抑制したマウスにおいてSTZ糖尿病の代謝異常が改善するメカニズムを調べた。その結果、骨格筋選択的にAMPK活性を抑制した時の代謝改善効果が、骨格筋から分泌されるマイオカインによることを見出した。本研究結果は、骨格筋から分泌されるマイオカインが1型糖尿病の病態形成にも関与する可能性を示している。

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Published: 2021-02-19  

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