Optimal ultraviolet wavelength for immune regulation and development of ultraviolet-LED phototherapy

2019 Fiscal Year Final Research Report

• Project/Area Number: 17H04242
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagoya City University
• Principal Investigator: Morita Akimichi 名古屋市立大学, 医薬学総合研究院(医学), 教授 (30264732)
• Co-Investigator(Kenkyū-buntansha): 山崎 小百合 名古屋市立大学, 医薬学総合研究院(医学), 教授 (70567255)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 紫外線 / 免疫制御 / 制御性Ｔ細胞 / 光線治療 / LED

Outline of Final Research Achievements

Wavelength analysis to induce iTreg showed inhibition of delayed-type hypersensitivity and induction of Treg at 310 nm and induction of nTreg at 290-300 nm. Demethylation in Treg-related genes leads to Tregs with stable inhibitory functions. The decreased ability to suppress Treg in patients with psoriasis returned to almost normal after phototherapy, indicating that phototherapy restored Treg function. Regarding the induction of Treg in human skin lesions, we succeeded in FACS analysis from a small amount of whole blood collected as lesional blood and in the separation of CD4/CD8 by high-speed cell sorter. We also succeeded in the separation of regulatory T cells.

Free Research Field

要入力

Academic Significance and Societal Importance of the Research Achievements

今回の研究成果は、光線療法のメカニズムの一部を明らかにするとともに、乾癬の病態がより明確になることが期待される。またTh17細胞がその病態に関与していると考えられている自己免疫性脳脊髄炎（多発性硬化症）や様々な自己免疫疾患に対し光線療法が応用できる可能性があり、今回の研究がその足がかりとなる可能性がある。