Elucidation of genetic factors of muscle injury risk

2020 Fiscal Year Final Research Report

• Project/Area Number: 17H04752
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Juntendo University (2018-2020); National Institute of Fitness and Sports in Kanoya (2017)
• Principal Investigator: Miyamoto Eri 順天堂大学, スポーツ健康科学研究科, 助教 (00793390)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 遺伝子多型 / 肉離れ / 骨格筋 / 材料特性

Outline of Final Research Achievements

The present study examined the associations of candidate gene polymorphisms with muscle injury risk in Japanese athletes. Four gene polymorphisms (ACE I/D [rs1799752], COL1A1 A/C [rs1107946], COL22A1 A/C [rs11784270]・T/C [rs6577958]）were associated with muscle injury risk in Japanese athletes. Our results suggest that the COL1A1 A/C polymorphism affects risk of muscle injury by altering the properties of muscle tissue, potentially owing to different composition of type I collagen.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、人が生まれながらに持つ遺伝子多型が、骨格筋の特性に影響し、肉離れの受傷リスクに影響することを明らかにした。この結果は、骨格筋の特性をターゲットとした新たな予防法の開発、さらには個人の遺伝的体質を考慮したスポーツ外傷・障害予防法の構築につながる知見である。