Search for RNA in body fluids that can evaluate the exposure dose of children and develop novel diagnostic methods

2020 Fiscal Year Final Research Report

• Project/Area Number: 17H04761
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Childhood science (childhood environment science)
• Research Institution: Hirosaki University
• Principal Investigator: Chiba Mitsuru 弘前大学, 保健学研究科, 准教授 (20583735)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 被ばくバイオマーカー / 血清中miRNA

Outline of Final Research Achievements

In this study, it was revealed that the radiosensitivity of leukocytes in childhood and adult mice differs depending on age and post-exposure time. In addition, it was clarified that changes in the type and amount of serum miRNA differed between childhood and adulthood, suggesting that radiosensitivity also differs depending on the radiation dose and time of irradiation. These results suggest that biomarkers for estimating radiation damage should be used according to the dose and elapsed time after irradiation.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では子ども期と大人期では白血球の放射線感受性に違いが生じることや、血清中miRNAの種類や量の変化が生じじることを明らかにした。この成果は、放射線被ばくバイオマーカー開発には年齢や被ばく後時間を考慮しなければいけないことを示唆した。日本は原子力災害を複数回経験した国であり、学校・地域住民への安全対策や緊急被ばく医療体制の整備は国家的責務である。今後世界中で起こりうる核テロや原子力災害への対応医療の備えとして、新たな子どもの被ばく診断技術の開発は不可欠な命題であり、本分野に貢献する研究は、日本が果たすべき世界からの信頼回復や大きな国際貢献につながる。