Regulation of nuclear receptor for vocal fold fibrosis

2018 Fiscal Year Final Research Report

• Project/Area Number: 17H06818
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto University
• Principal Investigator: HIWATASHI Nao 京都大学, 医学研究科, 医員 (10808778)
• Project Period (FY): 2017-08-25 – 2019-03-31
• Keywords: 声帯瘢痕 / 核内レセプター / NR4A1 / TGF-β

Outline of Final Research Achievements

Vocal fold fibrosis is intractable, and the regulation of TGF-β is essential, whereas selective targeting therapy is also needed to avoid some side effects. We focused on a selective agonist of NR4A1, Cytosporone B (Csn-B). To investigate the efficacy of Csn-B, realtime-PCR and gel contraction assay were employed. The results were as follows. Cells cultured with Csn-B showed significant suppression of fibrosis-related gene expressions, and gel contraction.

Free Research Field

耳鼻咽喉科学

Academic Significance and Societal Importance of the Research Achievements

本研究により、Csn-Bの投与がTGF-β経路を選択的に制御し、より副反応の少ない治療選択を提示しうることを証明した。声帯瘢痕への薬剤投与経路としては局所注射が可能なため、従来のCsn-Bの全身投与による線維化抑制と異なり、より臨床応用できる可能性が高いと考える。本研究成果として、海外学会1回、国内学会１回、英文誌掲載として評価を受けた。