Regulation of tissue morphogenesis by mechanosensor channel Piezo1

2017 Fiscal Year Final Research Report

• Project/Area Number: 17H07332
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: National Institute for Basic Biology
• Principal Investigator: Tanaka Keiko (野々村恵子) 基礎生物学研究所, 初期発生研究部門, 助教 (70799246)
• Research Collaborator: Patapoutian Ardem スクリプス研究所, ドリス神経科学センター, 教授
• Project Period (FY): 2017-08-25 – 2018-03-31
• Keywords: Piezo / 機械的な力 / 組織形態形成

Outline of Final Research Achievements

It remains obscure how mechanical forces affect phenomena in vivo. I have been focusing on Piezo channels, which were identified as mechanosensor proteins several years ago. I have found that Piezo is required for proper tissue morphogenesis. In this research project, in order to clarify the relationship between Piezo protein and tissue morphology consisting of many cells, I have looked for changes induced by Piezo activation in these cells by immunostaining. I observed changes in the amount and/or localization of proteins for cytoskeleton and cellular adhesion. In addition, I have been setting up systems to detect Piezo activity in vivo and in vitro.

Free Research Field

発生生物学