2019 Fiscal Year Final Research Report
Role of iron as dietary modulators of brain ageing
| Project/Area Number |
17K00877
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Seitoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
許斐 亜紀 安田女子大学, 家政学部, 講師 (40529658)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 老化 / 脳 / 鉄 / マンガン / 行動異常 / カテコラミン |
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| Outline of Final Research Achievements |
We investigated the role of iron as modulators of brain ageing. In iron-deficient rats, abnormal behaviors in an open filed were observed. In brain parts, decrease of iron and increase of manganese were remarkable. In some brain parts such as cerebrum cortex and cerebellum, dietary manganese-dependent manganese increase was enhanced by iron deficiency. In iron-deficient rats, generalized abnormalities in catecholamine metabolites and serotonin metabolites were observed. New estimation method of iron requirements using mathematical model was attempted also. Iron deficiency is common in Japanese women. These results suggest that prevention of brain ageing and brain degeneration is possible using iron supplementation.
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| Free Research Field |
栄養学、食生活学、衛生学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の学術的意義の1つは、鉄欠乏は動物の行動異常を伴い、特に、オープンフィールド投入直後にすくみ行動が見られることを見出したことである。新規環境におけるすくみ行動は、認知症患者やパーキンソン病患者が新規環境に対して戸惑う状況に類似したものである。また、鉄欠乏に伴う脳のマンガン蓄積の様態が脳の部位によって異なることを、数理解析を用いて明示し、鉄欠乏にカテコラミン代謝やセロトニン代謝の異常を伴うことを示した点も挙げられる。社会的意義は、本研究の成果に基づき、鉄補充による脳の老化および脳変性疾患の防止につながる可能性を示し得たことである。
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