Osteoinductivity and osteoconductivity of non-oxide ceramics

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K01389
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: Pezzotti Giuseppe 京都工芸繊維大学, 材料化学系, 教授 (70262962)
• Co-Investigator(Kenkyū-buntansha): 松田 修 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00271164) ; 山本 俊郎 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40347472) ; 足立 哲也 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10613573)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 窒化ケイ素 / 人工関節 / 骨伝導 / 骨誘導 / 間葉系幹細胞 / 骨芽細胞

Outline of Final Research Achievements

In modern medicine, there is an increasing demand for developing a new implant material having high osteoconductivity and, concurrently, antibacterial properties in order to safely perform artificial joint replacement surgery on patients including elderly persons. We previously reported that non-oxide ceramic silicon nitride, which has excellent mechanical properties and biocompatibility, also shows antibacterial activity against Staphylococcus epidermidis and periodontal disease bacteria. However, basic research on the effect of silicon nitride on osteoconduction and osteoinduction has yet not been performed in details. This project clarified the chemistry behind the supportive effect of silicon nitride on osteoblasts and mesenchymal stem cells, and examined whether silicon nitride could be a candidate for the next-generation artificial joint device.

Free Research Field

生体材料学

Academic Significance and Societal Importance of the Research Achievements

窒化ケイ素は優れた骨伝導性と骨誘導性を有することから、基礎疾患を有する高齢者においても、迅速で強固な骨結合を獲得することが期待できる。窒化ケイ素は超高齢社会において次世代のインプラント材料として有望である。