Renalase in the skeletal muscle contributes to cell protective effect

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K01839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: TAKEKOSHI Kazuhiro 筑波大学, 医学医療系, 教授 (40261804)
• Co-Investigator(Kenkyū-buntansha): 中田 由夫 筑波大学, 体育系, 准教授 (00375461) ; 大森 肇 筑波大学, 体育系, 教授 (20223969) ; 前田 清司 筑波大学, 体育系, 教授 (30282346)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: レナラーゼ / 運動 / 筋肉

Outline of Final Research Achievements

Renalase is a recently discovered flavin adenine dinucleotide (FAD) - dependent soluble monoamine oxidase. Its primary functions include catecholamine metabolism and blood pressure regulation. Renalase is predominantly expressed in the proximal tubule in the kidney. It is also expressed in other tissues, including the skeletal muscle, heart, and intestine.However, it remains unknown whether exercise could affect renalase expression.In this study, renalase expression in the skeletal muscle was increased by acute exercise, which was regulated by HIF-1α and NF-κB. In contrast, mRNA expression of Sp1 was unchanged in both the soleus and plantaris muscle following exercise when examining the contribution of catecholamine metabolic function in the skeletal muscle to renalase expression. In addition, renalase expression in the kidney was decreased by acute exercise.

Free Research Field

スポーツ医学

Academic Significance and Societal Importance of the Research Achievements

運動を行った場合の血清レナラーゼが上昇することを初めて明らかにした。さらにその機序と生理的意義を解明したことで、今後運動療法の分子機序の理解につながる可能性がある。