2022 Fiscal Year Final Research Report
Development of exercise therapy for obesity and malnutrition on the basis of the neural regulatory mechanism of appetitive motives
| Project/Area Number |
17K01860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Osaka Metropolitan University (2022)
Osaka City University (2017-2021) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Keywords | 食意欲 / 食行動 / 促進・抑制のバランス / 脳磁図 / ストレス / 疲労 / 疲労感 |
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| Outline of Final Research Achievements |
It has been thought that stress and fatigue prevalent in modern society affect behaviors related to food intake. We examined the alterations in neural response to the visual food stimuli caused by mental stress and fatigue sensation in the current study. The decrease of subjective appetite and the decrease of alpha band power in the frontal pole during viewing food images were caused by an acute social stress. The increase of appetite for fatty foods was observed when physical fatigue sensation was induced and the increase of appetite was related to the theta band power in the supplementary motor area during viewing the food images. These findings are expected to contribute to the understanding of the neural mechanisms by which mental stress and fatigue sensation affect the behaviors related to food intake in modern society.
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| Free Research Field |
運動生体医学
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| Academic Significance and Societal Importance of the Research Achievements |
現代社会において肥満や痩せが問題となっているが，ストレスや疲労を抱えることで食意欲の促進と抑制のバランスに悪影響が出る事がその背景にあると考えられる．本研究では，研究責任者が開発した食意欲の促進・抑制に働く脳内ネットワークに関する画期的な脳科学的評価系を応用することで，ストレス・疲労感により引き起こされる食意欲変容の機序の一端を明らかにすることに成功した．本評価系を用いることで，種々の状況下で食意欲が変容する理由を脳のレベルで明らかにできることが実証されたことと併せて，食意欲の促進と抑制を制御する生理学的機構の正常化を目指した運動を含めた介入法の開発に資する成果であり，その社会的意義は大きい．
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