Biochemical characterization of an inflammation related protein, mTOC (Celastramycin binding protein)

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K07346
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Shinshu University (2018-2019); Tokyo Women's Medical University (2017)
• Principal Investigator: Tomita Takeshi 信州大学, 学術研究院医学系, 准教授 (20302242)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: C1D / MTR4 / 亜鉛フィンガータンパク質

Outline of Final Research Achievements

mTOC (Celastramycin binding protein) is a zinc finger protein composed of -2000 amino acids. It is widely expressed mammalian cells, but its biological functions remained unknown. Our previous experiments revealed that anti-inflammatory effects driven by Celastramycin were due to its binding to mTOC. In this study, to elucidate molecular mechanisms of mTOC, mTOC and its associating factors including MTR4 and C1D were investigated to find out new information regarding with them.

Free Research Field

生物化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、セラストラマイシン結合タンパク質とその関連タンパク質であるMTR４やC1Dの細胞内における機能に関する新たな知見を得ることができた。これらの基礎的知見は、炎症における細胞内のタンパク質ータンパク質相互作用の変化を解析を行う上で有用な情報となる。将来的な細胞内の炎症ネットワーク解析に役立つと考えられる。