The role of T6SS in infection and pathogenesis of Helicobacter cinaedi isolated form human and animals.

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: University of Miyazaki
• Principal Investigator: Taniguchi Takako (岩田喬子) 宮崎大学, 産業動物防疫リサーチセンター, 助教 (50500097)
• Co-Investigator(Kenkyū-buntansha): 三澤 尚明 宮崎大学, 産業動物防疫リサーチセンター, 教授 (20229678)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: Helicobacter cinaedi / Ⅵ型分泌装置 / TssG遺伝子 / 動物感染実験

Outline of Final Research Achievements

Helicobacter cinaedi causes bacteremia and inflammation of subcutaneous tissue in humans. To clarify the role of the type VI secretion system (T6SS) in H. cinaedi, the pathogenicity of a mutant strain harboring a deletion in a T6SS-related gene, TssG, was compared for pathogenicity with that of a wild-type strain. In addition, mice infected with H. cinaedi were administered some antimicrobials orally to establish a useful treatment method. Although the suggested that suggested that combined administration of ABPC and MINO or administration of IPM/CS alone would be effective for eliminating H. cinaedi, further studies to establish an ideal administration method will be required.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

H. cinaediによるヒト菌血症や軟部組織の炎症などは、抗菌薬の投与により寛解するが、30～60％の患者で再燃するという報告もあり、有効な治療法は確立していない。病原因子の分泌装置としての機構であるⅥ型分泌装置（T6SS）の関連遺伝子(TssG)は、病原性への関与が低いことが示唆されたが、H. cinaedi感染マウスを用いた抗生物質投与試験において、今後の有効な治療法に繋がる新な知見が得られた。